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Traditional Chinese medicine extract for preventing and treating AD (Alzheimer's disease) and application of extract

An Alzheimer's disease and extract technology, which is applied in the field of traditional Chinese medicine extracts for the prevention and treatment of Alzheimer's disease, and achieves the effects of good curative effect, suitable for clinical popularization and low price

Inactive Publication Date: 2015-11-18
黑龙江葆纳生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although drynariae is a traditional Chinese medicine for invigorating the kidney, there are few reports on the use of drynariae in the treatment of AD.

Method used

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  • Traditional Chinese medicine extract for preventing and treating AD (Alzheimer's disease) and application of extract

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation of embodiment 1 Chinese medicine extract

[0042] Take Drynaria drynariae 5000g, soak it in 20L 60% ethanol overnight, heat and reflux for extraction for 2 hours, filter, collect the filtrate, extract the dregs twice with 10L 60% ethanol, combine the filtrate, and concentrate under reduced pressure to obtain an extract with a relative density of 1.15. Disperse and dissolve the extract in water so that the concentration of the aqueous solution is 1g / mL, and load the sample on the AB-8 macroporous adsorption resin column. The diameter-to-height ratio is 1:10, the adsorption flow rate is 3BV / h, static adsorption is 30min, and the impurity is removed with 3 times the resin volume of water, the impurity removal flow rate is 5BV / h, and then eluted with 5 times the resin volume of 75% ethanol , the elution flow rate is 5BV / h, the ethanol eluent is collected, the solvent is recovered, and dried under reduced pressure to obtain.

Embodiment 2

[0043] The preparation of embodiment 2 Chinese medicine extract

[0044] Take Drynaria drynaria 5000g, soak in 10L water overnight, heat and reflux to extract for 0.5h, filter, collect the filtrate, concentrate under reduced pressure to obtain an extract with a relative density of 1.15. Disperse and dissolve the extract in water so that the concentration of the aqueous solution is 0.01g / mL, and load the sample on the AB-8 macroporous adsorption resin column. The ratio of column diameter to height is 1:3, the adsorption flow rate is 3BV / h, static adsorption is 30min, the impurity is removed with 2 times the resin volume of water, the impurity removal flow rate is 3BV / h, and then washed with 50% resin volume 50% ethanol The elution flow rate is 3BV / h, the ethanol eluent is collected, the solvent is recovered, and dried under reduced pressure to obtain.

Embodiment 3

[0045] The preparation of embodiment 3 Chinese medicine extracts

[0046] Take drynaria drynaria 5000g, soak it in 50L of 100% ethanol overnight, heat and reflux for extraction for 1 hour, filter, collect the filtrate, extract the medicinal residue once with 25L of 100% ethanol, combine the filtrate, and concentrate under reduced pressure to obtain an extract with a relative density of 1.15. Disperse and dissolve the extract in water so that the concentration of the aqueous solution is 0.5g / mL, and load the sample on the D-101 macroporous adsorption resin column. The column diameter-to-height ratio is 1:20, the adsorption flow rate is 9BV / h, static adsorption is 30min, and the impurity is removed with 1 times the resin volume of water, the impurity removal flow rate is 9BV / h, and then washed with 7 times the resin volume of 95% ethanol The elution flow rate is 6BV / h, the ethanol eluent is collected, the solvent is recovered, and dried under reduced pressure to obtain.

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Abstract

The invention discloses a traditional Chinese medicine extract for preventing and treating the AD (Alzheimer's disease), a preparation method and an application of the extract. A crude extract is obtained through extraction with water or an organic solvent and then is purified with an organic solvent extraction method or macro-porous resin adsorption column chromatography, the required traditional Chinese medicine extract can be obtained, the content of total flavonoids in the traditional Chinese medicine extract is 20%-90%, and the content of neoeriocitrin is 2%-20%. Experiments prove that the traditional Chinese medicine extract has the better curative effect on the classical symptom, namely, learning and memory impairment, of a patient suffering from the AD, is obviously superior to a fortune's drynaria rhizome medicinal material or a simple aqueous extract of fortune's drynaria rhizomes, and is small in toxic and side effect, cheap and suitable for clinical popularization and usage.

Description

technical field [0001] The invention belongs to the field of medical applications, and in particular relates to a traditional Chinese medicine extract for preventing and treating Alzheimer's disease and its application. Background technique [0002] Alzheimer's Disease (AD, also known as senile dementia) is the most common neurodegenerative disease and the main cause of dementia so far. Among all dementia patients, up to 50%-60% are AD. AD has become an important public health problem. According to data, there were 24 million AD patients in the world in 2001. With the increase of human life expectancy, the number of patients is expected to double every 20 years. By 2040, there will be 81 million AD patients in the world, which will bring great benefits to human society. come a huge burden. Therefore, the development of drugs to prevent and treat Alzheimer's disease and improve cognitive dysfunction in Alzheimer's disease has become the research focus of medical workers fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/126A61P25/28A23L1/29A23L33/00
Inventor 张宁单军娜耿放韩振远顾婷刘俊岑于修芳
Owner 黑龙江葆纳生物科技有限责任公司