Preparation method of assistant hypoglycemic corn-stigma extractive capsules

A corn silk extract and hypoglycemic technology, which is applied in food preparation, capsule delivery, medical preparations containing active ingredients, etc., can solve the problem of unclear active ingredients for hypoglycemia, lack of scientific quality standards, and unsatisfactory hypoglycemic effect and other problems, to achieve the effect of no toxic side effects, optimize the extraction time, and optimize the number of extraction times

Inactive Publication Date: 2015-12-09
华心愉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically used to treat diabetes, high blood pressure and other diseases, the curative effect is satisfactory, but the process is rough, the extract is a mixture, the active ingredients for lowering blood sugar are not clear, the quality standards are not scientific, and the effect of lowering blood sugar is not ideal and unstable

Method used

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  • Preparation method of assistant hypoglycemic corn-stigma extractive capsules
  • Preparation method of assistant hypoglycemic corn-stigma extractive capsules
  • Preparation method of assistant hypoglycemic corn-stigma extractive capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The extraction of the total flavonoids of corn silk of embodiment one

[0020] Remove impurities from the corn silk, dry it, cut it off, weigh 100g of the corn silk, soak it in 50% ethanol for 2 hours, the ratio of solid to liquid is 1:10, reflux extraction, extraction 2 times, 1h / time, the extraction temperature is 60°C; the filtrate is filtered After that, the ethanol was recovered to make an extract, the total flavonoid content was 0.61g, and the yield was 0.61%.

Embodiment 2

[0021] The extraction of embodiment two corn silk total flavonoids

[0022] Remove impurities from the corn silk, dry it, cut it off, weigh 100g of the corn silk, soak in 90% ethanol for 2 hours, the ratio of solid to liquid is 1:22, reflux extraction, extraction twice, 1.5h / time, the extraction temperature is 90°C; the filtrate Filtrate, recover ethanol, and make an extract, the total flavonoid content is 0.97g, and the yield is 0.97%.

Embodiment 3

[0023] The extraction process of the total flavonoids of corn silk of embodiment three, orthogonal experiment

[0024] Four factors and three levels of orthogonal experiments were used to optimize the optimal extraction process.

[0025] 1. Research on extraction process

[0026] 1.1 Determination of factor levels:

[0027] The main factors affecting the extraction of total flavonoids from corn silk were ethanol concentration, solid-liquid ratio, and extraction time, so four factors and three levels of orthogonal experiments were used to optimize the optimal extraction process. See Table 1.

[0028] Table 1 Orthogonal test factor level table

[0029]

[0030] 1.2 Preparation of the test solution:

[0031] Remove impurities from the corn silk, dry it, cut it off, weigh 100g of the corn silk, carry out reflux extraction twice according to the number of the orthogonal experiment, filter the filtrate, recover ethanol, make an extract, and measure the total flavonoid content...

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Abstract

The invention provides a preparation method of assistant hypoglycemic corn-stigma extractive capsules. The active ingredient of the corn stigma extractive capsules is corn-stigma total flavones. A corn-stigma extractive is obtained through extraction by means of an ethyl alcohol organic solvent, and the marking ingredient of the corn-stigma extractive is the total flavones. An optimal process is obtained through an orthogonal experiment, and the content of the corn-stigma total flavones is high. A process for preparing the corn-stigma extractive capsules is optimized. The corn-stigma extractive capsules pass an assistant hypoglycemic function test, and the high-dosage corn-stigma extractive can remarkably inhabit continuous blood glucose rise (p<0.05) of a mouse model suffering from diabetes caused by alloxan. The corn-stigma extractive capsules belong to a newly-developed pure natural assistant hypoglycemic health-care food which is remarkable in hypoglycemic effect, free of toxic and side effects, safe and effective and can be taken for a long time.

Description

technical field [0001] The invention relates to a preparation method of a health food that assists in lowering blood sugar in the field of traditional Chinese medicine, in particular to a preparation method of corn silk extract capsules that assist in lowering blood sugar. Background technique [0002] Diabetes is a group of systemic endocrine and metabolic diseases. Its pathophysiological changes are relative or absolute deficiency of insulin secretion, which causes sugar, fat, protein and secondary vitamin, water and electrolyte metabolic disorders, resulting in hyperglycemia, hyperlipidemia and blood With the increase of viscosity, most of the patients will have symptoms such as polydipsia, polyphagia, polyuria, weight loss and general weakness, which is a kind of disease that is difficult to cure at present. [0003] Once diabetes is not well controlled, it will lead to various complications, leading to heart, brain, nerve, eye, foot, kidney and other parts of the failur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/48A61P3/10A23L1/29A23L33/00
Inventor 华心愉
Owner 华心愉
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