Preparation method of 3-ethyl-4-7-aminocephalosporanic acid
A technology of cephalosporanic acid and vinyl, which is applied in the field of preparing 7-amino-3-vinyl-4-cephalosporanic acid, can solve the problems of low equipment requirements, low production cost, high raw material cost, etc., and achieve short reaction route, The effect of less three wastes and low cost of raw materials
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[0021] Example 1: Preparation of 7-amino-3-vinyl-4-cephalosporanic acid
[0022] In a 50 ml three-necked flask, add 46 mg (0.1 mmol) of p-methoxybenzyl 7-phenylacetamido-3-vinyl-4-cephalosporanic acid, solid super acid catalyst S 2 O 8 2- / SnO 2 -Fe 2 O 3 23mg, 46mg of dichloromethane, 46mg of isoamyl acetate, 138mg of acetonitrile, react at 5°C for 5 hours, then cool the reaction solution to room temperature, then add 10mg of activated carbon to the reaction solution for decolorization, filter, and concentrate the filtrate to precipitate a pale yellow Solid 18.3mg, yield 81%. m.p.180~182℃, purity ≥96%.
[0023] IR(KBr)cm -1 : 3158,3010,2890,1800,1615,1540,1060.
[0024] 1 H-NMR(D 2 O,400MHz)δ:3.52~3.67(2H,ABq,C 2 H 2 ),5.02~5.05(1H,dd,C 6 -H), 5.19~5.20(1H,dd,C 7 -H), 5.34~5.37 (1H, d, Vinyl-H), 5.38~5.40 (1H, d, Vinyl-H), 6.68~6.72 (1H, dd, Vinyl-H).
Example Embodiment
[0025] Example 2: Preparation of 7-amino-3-vinyl-4-cephalosporanic acid
[0026] In a 50 ml three-necked flask, add 46 mg (0.1 mmol) of p-methoxybenzyl 7-phenylacetamido-3-vinyl-4-cephalosporanic acid, solid super acid catalyst S 2 O 8 2- / SnO 2 -Fe 2 O 3 46mg, methylene chloride 46mg, isoamyl acetate 92mg, acetonitrile 230mg, react for 10 hours at 0°C, then cool the reaction solution to room temperature, then add 10mg activated carbon to the reaction solution for decolorization, filter, and concentrate the filtrate to precipitate a pale yellow The solid was 18.5 mg, and the yield was 82%. m.p.180~182℃, purity ≥96%.
Example Embodiment
[0027] Example 3: Preparation of 7-amino-3-vinyl-4-cephalosporanic acid
[0028] In a 50 ml three-necked flask, add 46 mg (0.1 mmol) of p-methoxybenzyl 7-phenylacetamido-3-vinyl-4-cephalosporanic acid, solid super acid catalyst SO 4 2- / SnO 2 -Fe 2 O 3 46mg, 46mg of dichloromethane, 138mg of butyl acetate, 230mg of acetonitrile, reacted at 0℃ for 10 hours, then the reaction solution was cooled to room temperature, and then 10mg of activated carbon was added to the reaction solution for decolorization, filtered, and the filtrate was concentrated to precipitate a pale yellow solid 18.2mg, yield 80.6%. m.p.180~182℃, purity ≥96%.
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