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Single particle scattering measurement apparatus based on microfluidic chip particle capturing

A microfluidic chip and scattering measurement technology, which is applied in the field of optics and measurement, can solve problems such as the inability to measure large-angle single-particle scattering fields

Active Publication Date: 2015-12-09
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

[0006] In view of the defects of the prior art, the purpose of the present invention is to measure the scattering field distribution of a single particle in a large angle range in a plane, aiming to solve the problem that the original solution cannot perform large-angle single particle scattering field measurement; another purpose of the present invention It is to solve the problem of establishing and capturing the single particle environment

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  • Single particle scattering measurement apparatus based on microfluidic chip particle capturing
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  • Single particle scattering measurement apparatus based on microfluidic chip particle capturing

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Embodiment Construction

[0028] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0029] The invention consists of four parts: a light source, a beam splitting optical path system, an alignment measurement component, and a detection component; at the same time, the invention includes the structural design and manufacture of the sample microfluidic chip 9 .

[0030] The design and manufacture of the microfluidic chip 9, the microfluidic chip 9 is made of polydimethylsiloxane material, and the designed chip structure is as follows: Figure 4 As shown, the designed chip flow channel structure is simulated by Comsol software, and the simulation results of the scattered field distrib...

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Abstract

The present invention discloses a single particle scattering measurement apparatus based on microfluidic chip particle capturing. The single particle scattering measurement apparatus comprises a light source, a light splitting light path, a measurement alignment assembly, a detection assembly, and a microfluidic chip. According to the present invention, the theoretical scattering curve reference of the Mie scattering theory calculation is combined to complete the large angle range scattering field measurement within the single particle circumference range; and the microfluidic chip technology is combined, such that the single particle capturing and the single particle environment constructing are solved.

Description

technical field [0001] The invention belongs to the field of optics and measurement, and more specifically relates to a particle capture type single particle scattering measurement device based on a microfluidic chip. Background technique [0002] As an important characteristic, light scattering is widely used in many fields such as biology, medicine, chemical industry, environmental protection, etc. There are many methods for light scattering measurement, including dynamic light scattering method, small angle forward scattering method, angle scattering method, total scattering method At present, there are many methods for particle scattering measurement combined with microfluidic chip technology. [0003] One is the measurement of small-angle scattering characteristics (distribution of scattering field within a small angle range of the detection object) based on CCD detection, using a laser 1 with better beam quality as a light source, coupling the beam into a single-mode o...

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Application Information

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IPC IPC(8): G01N21/49
Inventor 杨克成夏珉戴杰宫宝玉
Owner HUAZHONG UNIV OF SCI & TECH