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Bioerodible magnesium alloy microstructures for endoprostheses

A bio-erosion, magnesium alloy technology, applied in prosthesis, surgery, medical science, etc., to achieve the effect of improving ductility

Inactive Publication Date: 2015-12-09
BOSTON SCI SCIMED INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, many of these bioerodible materials have significant disadvantages
These disadvantages include the type and release rate of the erosion product and the mechanical properties of the material

Method used

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  • Bioerodible magnesium alloy microstructures for endoprostheses
  • Bioerodible magnesium alloy microstructures for endoprostheses
  • Bioerodible magnesium alloy microstructures for endoprostheses

Examples

Experimental program
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Embodiment Construction

[0016] figure 1 The stent 20 shown in is an example of an endoprosthesis. The stent 20 comprises a pattern of interconnected struts that form a structure that contacts the walls of the body lumen to maintain the patency of the body lumen. For example, stent 20 may have a tubular member defined by a plurality of cuffs 22 and a plurality of joints 24 extending and connecting adjacent cuffs. During use, the cuff 22 can expand from an initial small diameter to a larger diameter to contact the stent 20 against the vessel wall, thereby maintaining the patency of the vessel. Joints 24 provide stent 20 with flexibility and compliance that allow the stent to conform to the contours of the vessel. Other examples of endoprostheses include stent-grafts and stent-grafts.

[0017] At least one strut of stent 20 is adaptable to erosion under physiological conditions. In some cases, scaffold 20 is fully bioerodible. Stent 20 may comprise a bioerodible magnesium-aluminum alloy having a re...

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Abstract

A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Description

technical field [0001] The present invention relates to microstructures of bioerodible magnesium alloys for use in endoprostheses and methods of forming such microstructures. Background technique [0002] Endoprostheses can be used to replace missing biological structures, support damaged biological structures, and / or reinforce existing biological structures. Often, only the temporary existence of the endoprosthesis in the body is necessary to accomplish the medical purpose. However, surgical intervention for removal of the endoprosthesis leads to complications and may even be impossible. One approach to avoid the permanent presence of all or part of the endoprosthesis is to form all or part of the endoprosthesis from a bioerodible material. As used herein, the term "bioerodible" is understood as the sum total of microbial procedures or processes resulting only in the presence of an endoprosthesis in the body, which results in the gradual erosion of structures made of bioe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L31/02C22C23/02C22F1/06
CPCA61F2/82A61L31/022A61L31/14A61L31/148C22C23/02C22F1/06
Inventor 约翰森·S·斯廷森丹尼斯·A·博伊斯米尔雅各布·D·艾迪克托斯滕·肖伊尔曼路易斯·托斯詹·韦伯查尔斯·邓
Owner BOSTON SCI SCIMED INC
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