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A kind of medical anti-adhesive hydrogel dressing and preparation method thereof

A hydrogel and anti-adhesive technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of large pores in foam dressings, inappropriate loading of drugs or slow-release treatment of growth factors, easy growth of new granulation tissue on wounds, etc., to achieve Accelerates wound healing, avoids trauma or infection, and has the effect of simple types of raw materials

Active Publication Date: 2018-10-12
朗肽生物制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the large number of large pores in the foam dressing, the material is easy to adhere to cells, and the new granulation tissue on the wound surface is easy to grow in, thus forming adhesions. At the same time, the foam dressing has large pores and is not suitable for sustained-release therapy loaded with drugs or growth factors.

Method used

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  • A kind of medical anti-adhesive hydrogel dressing and preparation method thereof
  • A kind of medical anti-adhesive hydrogel dressing and preparation method thereof
  • A kind of medical anti-adhesive hydrogel dressing and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] A kind of preparation method of medical anti-adhesive hydrogel dressing is as follows: use methyl methacrylate monomer as polymerization raw material, take polyethylene glycol tetraacrylate as crosslinking agent, ammonium persulfate as thermal initiator, with following weight Mixing ratio: 23% methyl methacrylate, 9% polyethylene glycol tetraacrylate, 67% water, 1% ammonium sulfate, after mixing evenly, pour into the mold, heat at 65°C for 12 hours, polymerize and crosslink to obtain transparency Hydrogel material, after cleaning and freeze-drying, a hydrogel with a micro-porous structure is obtained. The prepared hydrogel is not adhered to the wound, has strong hydrophilicity, and can quickly absorb water. The average swelling rate is 408%. The wound is moist and has good elasticity, and has a rich micro-porous structure with a pore diameter of 20 μm to 100 μm, such as figure 1 shown.

Embodiment 2

[0032] A kind of preparation method of medical antisticking hydrogel dressing is as follows: use butyl methacrylate monomer as polymerization raw material, take polyethylene glycol divinyl sulfone as crosslinking agent, 2-hydroxyl-4'-(2-hydroxyl Ethoxy)-2-methylpropiophenone is used as a photoinitiator, mixed with the following weight ratio: butyl methacrylate 32%, polyethylene glycol divinyl sulfone 10%, water 57%, 2-hydroxyl-4 '-(2-hydroxyethoxy)-2-methylpropiophenone 1%, after mixing evenly, pour into the mold, and initiate cross-linking and polymerization under ultraviolet light with a wavelength of 320-400nm and a light intensity of 800uv / cm3 for 15-60 minutes , polymerized and cross-linked to obtain a hydrogel material, and after washing and freeze-drying, a hydrogel with a micro-porous structure was obtained. The prepared hydrogel was tested by experiments without sticking to the wound, with strong hydrophilicity, fast absorption of water, and average swelling rate It i...

Embodiment 3

[0034]A preparation method of a medical anti-adhesive hydrogel dressing is as follows: use hydroxyethyl methacrylate monomer as a polymerization raw material, polyethylene glycol dimethacrylate as a crosslinking agent, ammonium persulfate as a thermal initiator, and Mix in the following weight ratio: 20% hydroxyethyl methacrylate, 20% polyethylene glycol dimethacrylate, 59.5% water, 0.05% ammonium sulfate, after mixing evenly, pour into the mold, heat at 65°C for 24 hours, Polymerization and cross-linking to obtain a transparent hydrogel material, washing and freeze-drying to obtain a micro-porous hydrogel material, the prepared hydrogel has been tested by experiments without sticking to the wound, has strong hydrophilicity, can quickly absorb water, and has an average swelling rate of 724%, keep the wound moist, and have good elasticity, with rich micro-porous structure, such as figure 2 shown.

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Abstract

The present invention discloses a medical anti-adhesion hydrogel dressing, which comprises a hydrogel, wherein a methyl propiolate monomer, double or multi-functional group terminated-polyethylene glycol having unsaturated double bond, water and an initiator are further subjected to thermal initiation or photo initiation or radiation initiation polymerization so as to obtain the hydrogel, and the hydrogel has a micron porous structure. According to the present invention, the prepared hydrogel dressing has characteristics of no adhesion to wound, good water absorption and excellent mechanical property, and has a space micro-structure capable of loading drugs or growth factors so as to load various drugs or growth factors, achieve the functionalization treatment of the dressing, and achieve antibacterial, wound healing promoting and other functions.

Description

technical field [0001] The invention relates to a medical dressing, in particular to an anti-adhesive medical hydrogel dressing and a preparation method thereof. Background technique [0002] In my country, about tens of millions of people suffer from skin trauma due to accidents and surgeries every year. There are more than 10 million burns, wound treatments and surgical operations in China every year, and the related medical expenses each year reach a scale of 100 billion yuan. Among them, the cost of medical dressings for burns, wound treatment and surgical operations accounted for more than 3%, reaching more than 3 billion yuan. In addition, from a global perspective, chronic wound care such as decubitus and ulcers, which are closely related to the elderly due to the aging population, the growth factors of diabetes and obesity, and the increasing attention, have shown a growing interest in advanced wound dressings. market demand. An ideal wound dressing is essential fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/26A61L15/44
Inventor 全大萍曾莹杨习锋曾晨光邱锡波
Owner 朗肽生物制药股份有限公司
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