Application of two halogen-phenol compounds to effect of promoting angiogenesis

An angiogenesis and compound technology, applied in cardiovascular system diseases, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of low compliance, instability, inconvenient administration, etc. Effect

Inactive Publication Date: 2015-12-30
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it cannot be ignored that biomacromolecular drugs often face many problems such as difficulty in obtaining, instability, low bioavailability, inconvenient administration, and low compliance.

Method used

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  • Application of two halogen-phenol compounds to effect of promoting angiogenesis
  • Application of two halogen-phenol compounds to effect of promoting angiogenesis
  • Application of two halogen-phenol compounds to effect of promoting angiogenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0014] Example: Halophenol compounds 2,4',5'-trihydroxy-5,2'-dibromobenzophenone and 2',5-dibromo-2-(2-phenylimidazol-1-yl) Effect of methyl-4',5'-dihydroxybenzophenone on PTK787-induced vascular injury in transgenic zebrafish.

[0015] 1. Experimental method

[0016] 1. Preparation of Zebrafish Embryos

[0017] Select a healthy sexually mature female fish and one male fish and put them into the fish tank, and separate the two fish for overnight. The baffle is removed in the morning of the next day, and the male and female fish lay eggs (small grain size, transparent shape). After sterilizing the fertilized eggs, transfer them into the water for zebrafish embryo culture, and culture them under light control at 28°C

[0018] 2. Sample solution preparation

[0019] PTK787, LM49, and LW38a were prepared into 0.5g / L, 20g / L, and 100g / L mother solutions with dimethyl sulfoxide (DMSO), respectively.

[0020] 3. Effect of samples on angiogenesis in transgenic zebrafish

[0021] ...

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Abstract

The invention relates to two halogen-phenol compounds, namely 2, 4', 5'-trihydroxy-5, 2'-dibromo benzophenone and 2',5-dibromo-2-(2-phenyl imidazole-1-group) methyl-4',5'-dihydroxy benaophenonel, and novel pharmacological application of medicine compositions of the two compounds in the effect of promoting angiogenesis. According to the application of the two halogen-phenol compounds, the angiogenesis promotion effect of the two halogen-phenol compounds is defined, and the compounds have the specific effects that the length of a damaged internode blood vessel of a zebra fish can be remarkably increased, and the zebra fish suffering from vascular injury can be protected. The compounds can be used independently or in combination with other pharmaceutic adjuvant ingredients acceptable to pharmacy for preparing medicine having the angiogenesis promotion function, and potential application prospects in prevention and treatment of ischemic heart disease, apoplexy, muscle atrophy, far-end limb necrosis and the like are achieved.

Description

technical field [0001] The present invention belongs to the field of new uses of halophenol compounds, and specifically relates to the application of two halophenol compounds and their pharmaceutical compositions in promoting angiogenesis, specifically in the prevention and treatment of ischemic heart disease, Applications in stroke, muscle atrophy, necrosis of distal extremities and other diseases. Background technique [0002] Halophenol compounds have multiple biological activities such as anti-oxidation, anti-microbial, anti-tumor, anti-thrombotic, anti-inflammatory, α-glucosidase inhibition, protein tyrosine phosphatase (PTPIB) inhibition, and biological antifeedant. In order to solve the limitation of its biological source, the applicant designed and synthesized a variety of new halophenol compounds in the early stage, and found that these compounds have significant protection of vascular endothelial cells, anti-atherosclerosis, and protection of myocardial injury caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K31/12A61P9/14A61P9/00A61P9/10
Inventor 李青山高燕冯秀娥宋婷
Owner SHANXI MEDICAL UNIV
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