Pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof

A technology of acid-base indication and detection materials, which is applied in the field of medical detection, can solve the problems of inconspicuous color changes, high dose requirements, side effects of patients, etc., and achieve the effects of avoiding stimulation of pancreatic juice secretion, reducing pain of patients, and high sensitivity

Inactive Publication Date: 2015-12-30
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the color range of litmus paper is 5.0 to 8.0, and the color change is not obvious in the physiological pH and pancreatic juice pH range. The pH of pancreatic juice is often lower than 8.0, and the litmus test paper is even more useless at this time. At the same time, litmus has a high requirement for the leakage of pancreatic juice. Somet

Method used

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  • Pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof
  • Pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof
  • Pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof

Examples

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Embodiment 1

[0041] Weigh 1 g of thymol blue, dissolve it in 200 ml of absolute ethanol, dissolve it by ultrasonication, filter the filtrate, immerse the filter paper in the filtrate until the absorption is saturated, and dry to obtain the thymol blue pancreas leakage detection material of the present invention.

Embodiment 2

[0043] Weigh 1g of thymol blue, dissolve it in 200ml of absolute ethanol, boil and reflux for 1h, and filter while hot to obtain a thymol blue solution; at the same time, weigh 1g of bromothymol blue, dissolve it in 200ml of absolute ethanol, and reflux to make it Dissolved, and suction filtered to obtain bromothymol blue solution. Take equal volumes of thymol blue and bromothymol blue solution and mix, immerse the filter paper in the mixed solution of thymol blue and bromothymol blue solution until the absorption is saturated, and dry to obtain thymol blue and bromothymol blue solution of the present invention Liphenol blue mixed pancreatic leakage detection material.

[0044]Utilize the pancreatic leakage detection material that embodiment 1~2 makes to carry out following experiment:

[0045] A pancreatic juice was extracted from three random patients (Patient No. 1, No. 2, and No. 3) to obtain three different pancreatic juices, and the measured pH was 8.37, 7.87, and 8.49;...

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Abstract

The invention relates to the technical field of medical treatment, in particular to a pancreatic leakage detection material based on acid-base indication compound chemical color changes and application thereof. The pancreatic leakage detection material is a water absorption material comprising a solution loaded with acid-base indication compounds, and is prepared by preparing a solution through acid-base indication compounds and dropwise adding the solution to the water absorption material. The acid-base indication compounds are thymol blue or a mixture of thymol blue and bromothymol blue. By means of the pancreatic leakage detection material, tissue liquid with pancreatic juice and tissue liquid without pancreatic juice can be distinguished through obvious color changes under the condition of low-dosage pancreatic juice, and the high detection flexibility and the large detection range are achieved.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a pancreatic leakage detection material based on chemical discoloration of an acid-base indicating compound and an application thereof. Background technique [0002] Pancreatic fistula is the most common and serious complication after pancreatic surgery, and it is one of the main causes of severe abdominal infection and hemorrhage after pancreatic surgery. The main cause of pancreatic fistula is that after surgical suturing, there are small cracks in some places due to surgical sutures, and pancreatic juice leaks (pancreatic leakage). However, pancreatic juice is a colorless and odorless liquid, so doctors cannot immediately and accurately judge whether there is pancreatic juice leakage after surgical suture. How to visualize pancreatic juice leakage becomes the key to preventing pancreatic fistula. [0003] The concentration of bicarbonate in pancreatic juice is high,...

Claims

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Application Information

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IPC IPC(8): G01N21/80
Inventor 刘祥瑞苗毅周泉陆子鹏唐建斌蒋奎荣申有青
Owner ZHEJIANG UNIV
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