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Method for correcting blood glucose value of blood sample

A calibration method and blood sample technology, applied in the field of blood glucose calibration, can solve the problems of time-consuming preparation process and detection process, insufficient patient accuracy, etc., achieve high accuracy and eliminate the need for devices

Active Publication Date: 2015-12-30
DELBIO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there are some limitations in the field of measuring analytes by electrochemical methods, such as the need to use both direct current and alternating current in the detection process
In addition, the overly complicated structure of the test piece makes the preparation process and the detection process relatively time-consuming. In addition, the existing methods of detecting the hematocrit ratio and compensating the blood sugar value will be affected by the concentration of glucose or interfering substances in the blood sample. Errors, resulting in Accuracy of self-measurement by patients is still insufficient

Method used

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  • Method for correcting blood glucose value of blood sample
  • Method for correcting blood glucose value of blood sample
  • Method for correcting blood glucose value of blood sample

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0076] Experimental example 1: Obtain the linear relationship between the hematocrit index and the hematocrit

[0077]Prepare the same batch of blood glucose test strips and blood samples from the same blood specimen, adjust the blood glucose concentration of the blood samples to 175mg / dL, and process three groups of blood glucose test strips with hematocrit (%) of 9%, 42% and 71% respectively. Blood samples are tested.

[0078] The above-mentioned three groups of blood samples whose hematocrit (%) were 9%, 42% and 71% were processed with two experimental conditions, one of which was only processed by a high-voltage section to measure the hematocrit index (code name: Group A), and the other group is treated with the calibration method of the present invention (code name: Group B), and the instrument used is DELBiometer or CHInstrument potentiostat. Specifically, in group A, at room temperature (25±2°C, RH=60±5%), DELBio test strips were applied to blood samples with various h...

experiment example 2

[0080] Experimental example 2: Linear regression distribution relationship of hematocrit ratio index at different glucose concentrations

[0081] Prepare the same batch of blood glucose test strips and blood samples from the same blood sample, adjust the blood glucose concentration of the blood sample to 175mg / dL, and process five groups of glucose concentrations of 50, 175, 300, 470 and 600 (mg / dL) ) blood samples for testing.

[0082] The above five groups of blood samples with glucose concentrations of 50, 175, 300, 470 and 600 (mg / dL) were processed under two experimental conditions (ie, the voltage application conditions of the above-mentioned groups A and B). Depend on Figure 4 It can be seen that the hematocrit index obtained in group B is less affected by the glucose concentration than that in group A, that is, the hematocrit index obtained in group B is affected by the blood glucose concentration in the glucose concentration range of 40-600mg / dL small. In addition...

experiment example 3

[0083] Experimental Example 3: Using the hematocrit ratio to feed back the deviation ratio before and after the blood glucose level

[0084] Prepare the same batch of blood glucose test strips and blood samples from the same blood specimen, adjust the blood glucose concentration of the blood samples to 175mg / dL, and process three groups of blood glucose test strips with hematocrit (%) of 9%, 42% and 71% respectively. Blood samples are tested.

[0085] The above five groups of blood samples with hematocrit (%) of 9%, 42% and 71% were processed under three experimental conditions (ie no feedback group, feedback group A and feedback group B). Among them, the non-feedback group is the blood glucose value obtained by applying a first voltage to blood samples with different hematocrits (9%, 42% and 71%) on the DELBio test strip at room temperature. In group A with feedback, at room temperature (25±2°C, RH=60±5%), a DELBio test strip was applied to blood samples of various hematocri...

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Abstract

The invention discloses a method for correcting a blood glucose value of a blood sample. The method comprises the following steps: applying a first voltage to the blood sample, so as to obtain a first blood glucose value; applying a second voltage to the blood sample, so as to obtain a second blood glucose value; applying a third voltage to the blood sample, so as to obtain a hematocrit index of the blood sample; processing the hematocrit index and correcting the second blood glucose value. In the correcting process, the third voltage is higher than the first voltage. According to the method, at least three-phase voltages within a specific range are applied to the blood samples, so that sensing currents corresponding to the blood values and the hematocrit index corresponding to the blood sample can be obtained, and then the blood glucose concentration can be corrected and compensated according to the hematocrit index.

Description

technical field [0001] The invention relates to a method for correcting the blood sugar level of a blood sample, in particular to a method for correcting the blood sugar level of a blood sample with at least three-stage voltage applied. Background technique [0002] With the advancement of science and technology and the change of human living habits, the field of home care has been paid more and more attention. In addition to being able to grasp the real-time condition of patients at any time, many test items that originally had to be carried out in hospitals have been developed to home measurement. Measurement is a common detection item, and measuring blood glucose concentration is an important step in effective monitoring and treatment of diabetes. [0003] However, current household or portable blood glucose testing machines often have a large error value, which is a shortcoming and problem criticized by users. As for the reason, the most influential factor is the hemato...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416
Inventor 蔡宗轩银解语周忆安
Owner DELBIO
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