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Methods and systems for biomarker identification

A biomarker, microbial technology, applied in the field of biomarkers for mammalian conditions, can solve problems such as difficult to compare results, insufficient thorough analysis, etc.

Inactive Publication Date: 2017-09-29
PROCTER & GAMBLE CO
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is difficult to compare results between different patients and different examiners
Furthermore, despite the complexity of the oral microbiome and the suspected multibacterial nature of chronic oral infections, population investigations of gingivitis-associated microbiota are often limited to only a few culturable bacteria (e.g. "red complex" including gingival porphyrin mono Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola), which provided insufficient data points for a thorough analysis of the various microorganisms that may cause gingivitis

Method used

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  • Methods and systems for biomarker identification
  • Methods and systems for biomarker identification
  • Methods and systems for biomarker identification

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[0141] The examples herein are intended to illustrate the invention, but not necessarily to limit or otherwise define the scope of the invention.

[0142] Abbreviation list :

[0143] NG: Naturally occurring gingivitis

[0144] EG: experimental gingivitis

[0145] MGI: Modified / Mazza Gingival Index

[0146] BOP: bleeding on probing

[0147] MiGs: Microbial indices of gingivitis

[0148] RPM: Regression-Progression Model

[0149] PAM: segmentation algorithm around center point (clustering algorithm)

[0150] PCA: Principal Component Analysis

[0151] PCoA: Principal Coordinates Analysis

[0152] FDR: false discovery rate

[0153] COG: Clustering of homology groups

[0154] MiG: Microbial index of gingivitis

[0155] MiG: Microbial index of gingivitis susceptibility

[0156] ROC: Receiver Operating Characteristic

[0157] CI: confidence interval

[0158] KO: KEGG orthologs

[0159] RPM design Figure 1A The design of a longitudinal study of the development of gin...

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Abstract

The present invention provides a method of identifying biomarkers indicative of a condition in a subject mammal selected from the group consisting of the presence of a first disease, the presence of a first disease, and severity, susceptibility to primary disease, and combinations thereof. Also provided is a computer-aided system for identifying biomarkers indicative of a condition in a subject mammal.

Description

technical field [0001] The present invention relates to methods of identifying biomarkers indicative of a condition in a subject mammal. The present invention additionally relates to a computer-aided system for identifying biomarkers indicative of a condition in a subject mammal. Background technique [0002] A subject's health status is typically assessed based on a variety of symptoms. However, many of the symptoms used today are misleading due to their subjective descriptions and uncertain relationship to disease states. [0003] The term "biomarker (biomarker)" was introduced in 1989 as a Medical Subject Heading (MeSH) term, and is defined as an objectively measured and evaluated property of a normal biological process, a pathogenic process, or a therapeutic Indicators of Drug Response to Interventions. The discovery of biomarkers has grown enormously over the past few decades. Biomarkers play an important role in medicinal biology. Biomarkers are helpful for early ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/569G16B40/00G16B20/20
CPCG01N33/569C12Q1/689C12Q2600/112G16B40/00G16B20/00Y02A90/10G16B20/20
Inventor 李睿黄适T·何刘吉泉徐健
Owner PROCTER & GAMBLE CO
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