Rivastigmine containing external patch and preparation process thereof

A preparation process and patch technology, applied in the field of external patches containing rivastigmine and its preparation process, can solve the problems of environmental and human harm, achieve the effects of reducing individual differences, not polluting the environment, and high bioavailability of drugs

Inactive Publication Date: 2016-01-27
HARBIN ZHENJUNDI BIOLOGY MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the shortcomings of the original traditional patch, such a

Method used

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  • Rivastigmine containing external patch and preparation process thereof
  • Rivastigmine containing external patch and preparation process thereof
  • Rivastigmine containing external patch and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1: Preparation of external patch containing rivastigmine:

[0030] Raw materials

[0031] Prepare according to the following preparation process:

[0032] ① Dissolve rivastigmine and poloxamer in water, then add water emulsion type polyacrylate pressure sensitive adhesive, and mix well; ② apply the mixed glue to the anti-sticking layer, area 50000cm 2 , Heat and dry at 50℃, and then cover the backing layer. ③ Cut according to the required size, package, and then make a topical patch containing rivastigmine.

Example Embodiment

[0033] Example 2: Preparation of external patch containing rivastigmine:

[0034] Raw materials

[0035] Prepare according to the following preparation process:

[0036] ① Dissolve rivastigmine and poloxamer in water, then add water emulsion type polyacrylate pressure sensitive adhesive, and mix well; ② apply the mixed glue to the anti-sticking layer, area 50000cm 2 , Heat and dry at 60℃, and then cover the backing layer. ③ Cut according to the required size, package, and then make a topical patch containing rivastigmine.

Example Embodiment

[0037] Example 3: Preparation of external patch containing rivastigmine:

[0038] Raw materials

[0039] Prepare according to the following preparation process:

[0040] ① Dissolve rivastigmine and poloxamer in water, then add water-emulsion type polyacrylate pressure sensitive adhesive, and mix well; ②Apply the mixed glue to the anti-sticking layer with an area of ​​50000cm 2 , Heating and drying at 70℃, and then laminating the backing layer. ③ Cut according to the required size, package, and then make a topical patch containing rivastigmine.

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PUM

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Abstract

The invention discloses a rivastigmine containing external patch and a preparation process thereof. The external patch is formed by uniform mixing of the following components by weight: 100 parts of rivastigmine, 10-50 parts of poloxamer, 300-800 parts of water, and 800-1500 parts of a water emulsion type polyacrylate pressure sensitive adhesive. The specific preparation process includes: dissolving rivastigmine and poloxamer in water, then adding the water emulsion type polyacrylate pressure sensitive adhesive, and mixing the materials evenly, coating an anti-sticking layer with the drug-adhesive mixed solution evenly, performing heating drying at 40DEG C-70DEG C, and conducting compounding with a backing film; and carrying out slitting, die cutting and packaging, thus obtaining the external patch. The rivastigmine containing external patch provided by the invention performs transdermal drug delivery, releases drug evenly, and has mild and lasting effect. The preparation process provided by the invention is simple, reduces the production cost, and does not generate environmental pollution. Also, the rivastigmine containing external patch has the advantages of strong adhesion, no irritation to skin, no redness and swelling or itching phenomenon, good patient compliance, and convenient use and carrying.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a medicinal patch for external use, in particular to a patch for external use containing rivastigmine and a preparation process thereof. Background technique [0002] Alzheimer's disease (Alzheimer`sDisease, AD) is a primary gray matter encephalopathy, often occurs in the elderly. The incidence rate increases with age. The incidence rate is 3.0% for 65-74 years old, 18.7% for 75-84 years old, and 47.2% for those older than 85 years old. It is estimated that 22 million people will suffer from AD in the world after 25 years, and the number of AD patients will increase to 45 million by 2050. Therefore, elucidating the pathogenesis of AD and establishing its treatment plan is a problem that people should solve as soon as possible. According to research, cholinergic hypofunction can lead to cognitive dysfunction, and the cholinergic mechanism may invo...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/27A61K47/32A61P25/28
Inventor 张艳红杨洋
Owner HARBIN ZHENJUNDI BIOLOGY MEDICINE TECH CO LTD
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