Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of agmatine in preparing medicine for treating vascular endothelial injury with syndrome of sepsis

A vascular endothelium and sepsis technology, applied in the field of medicine, can solve the problems of large toxic and side effects, inaccurate drug efficacy, and high price.

Inactive Publication Date: 2016-02-03
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new drug for the treatment of sepsis vascular endothelial injury, which solves the problems of poor pertinence of drugs for inducing endothelial injury described in the prior art, inaccurate curative effect or high price, or relatively large toxic and side effects.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of agmatine in preparing medicine for treating vascular endothelial injury with syndrome of sepsis
  • Application of agmatine in preparing medicine for treating vascular endothelial injury with syndrome of sepsis
  • Application of agmatine in preparing medicine for treating vascular endothelial injury with syndrome of sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Experimental method

[0027] Mice were divided into sham operation group, CLP group, agmatine low-dose group, agmatine middle-dose group, agmatine high-dose group by random number table method, 14 in each group (8 for serum or plasma For the determination of indicators, 6 are only used for the detection of lung and liver vascular permeability). Fasting for 12 hours before operation, free drinking water. Anesthetized by intraperitoneal injection of 1% sodium pentobarbital (1ml / 100g body weight). After anesthesia, it was fixed and routinely disinfected. A 1 cm incision was made along the midline of the abdomen, and the cecum was separated with blunt dissecting forceps and pulled out from the abdominal cavity (to avoid damage to the mesenteric vessels). In the sham operation group, the cecum was brought back into the abdominal cavity and sutured layer by layer; in the CLP group, a No. 3 surgical thread was used to ligate 1 cm from the end of the cecum, and ...

Embodiment 2

[0035] Embodiment 2 experimental result

[0036]1. Expression of serum adhesion molecules ICAM-1 and VCAM-1 (Table 1): 24 hours after modeling, the levels of ICAM-1, VCAM-1 and MCP-1 in the serum of mice in the model group were significantly higher than those in the sham operation group, the difference was statistically significant (P<0.01); the levels of serum ICAM-1, VCAM-1, and MCP-1 in the high-dose agmatine group were significantly lower than those in the sepsis model group, and the difference was statistically significant ( P<0.01) or (P<0.05), the levels of serum ICAM-1, VCAM-1 and MCP-1 in the low-dose agmatine group and the middle-dose group were also significantly lower than those in the sepsis model group, but the effects Intensity is not as high as the high-dose group (results omitted).

[0037] Table 1 Effect of agmatine on serum ICAM-1 and VCAM-1 expression in septic mice

[0038]

[0039] Note: ICAM-1: intercellular adhesion molecule-1, VCAM-1: intervascula...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of agmatine in preparing a medicine for treating vascular endothelial injury with syndrome of sepsis. The inventor, taking a mouse as a model, proves that the agmatine takes a protective effect on vascular endothelial dysfunction induced by the sepsis, so as to provide new thinking and means for the clinical prevention and treatment of the vascular endothelial injury with syndrome of the sepsis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of agmatine in the preparation of medicines for treating sepsis vascular endothelial injury. Background technique [0002] Sepsis is an infection-induced systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS). Vascular endothelial dysfunction, as the pathological basis of sepsis, is the core link in its evolution to multiple organ dysfunction. Vascular endothelial cells (EC) not only constitute the barrier between blood and tissue, but also play an important role in many aspects such as inflammatory response, immune regulation, coagulation and anticoagulation, fibrinolysis, and regulation of vascular tension and permeability. EC activation, injury and dysfunction are important features of sepsis and multiple organ dysfunction syndrome (MODS), EC have potential diagnostic, therapeutic and prognostic value in sepsis and MODS and may becom...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/155A61P9/14A61P31/00
Inventor 梁华平田李星马晓媛范霞严军
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA