Composition capable of protecting liver with chronic alcoholic liver damage and preparation method of composition

A technology of alcoholic liver injury and protective effect, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems that have not been studied before, and achieve excellent results

Inactive Publication Date: 2016-03-02
BEIJING UNION UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Although the yellow grass, chitosan oligosaccharides and cordyceps polysaccharides all have protective...

Method used

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  • Composition capable of protecting liver with chronic alcoholic liver damage and preparation method of composition
  • Composition capable of protecting liver with chronic alcoholic liver damage and preparation method of composition
  • Composition capable of protecting liver with chronic alcoholic liver damage and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation of the extract of Herba japonica

[0041] Take 3kg of the flower of the yellow grass, crush it mechanically, add 1w / v% sodium hydroxide solution equal to the weight of the yellow grass, soak for 2 hours, then add acetic acid to adjust the pH to 6, and then use 90% ethanol 10 times the weight of the yellow grass Extraction, the extraction temperature is 50°C, extract for 3 hours, the extract is concentrated in vacuum at 30°C, the vacuum degree is 87kPa, and the relative density is 1.2g / ml extract; AB8 resin macroporous adsorption resin column adsorption, column volume 3L, sample loading flow rate 20ml / min, after the resin adsorption is complete, wash with 9L deionized water to remove impurities, and then wash the adsorbed impurities in the resin with 9L 20% and 9L 40% ethanol respectively . Finally, the active ingredients in the resin were eluted with 9L80% ethanol, concentrated in a vacuum at 25°C and a vacuum degree of 87kPa, and the etha...

Embodiment 2

[0042] Embodiment 2: the preparation of composition particle

[0043] The formula of the composition is: 1 kg of the extract of C. chinensis, 0.8 kg of chitosan oligosaccharide, 1 kg of cordyceps polysaccharide and 1 kg of dextrin, wherein the extract of C. chinensis is the extract mainly containing phenolic acid prepared in Example 1.

[0044] Mix the extract, chitosan oligosaccharide, cordyceps polysaccharide and dextrin according to the formula, add deionized water, adjust to a slurry with a solid content of 10%, and spray dry it to make powder. The air inlet temperature is 180°C , the air outlet temperature is 80° C. to obtain the composition powder, which is added with 20% starch, and is made into granules by fluidized bed granulation method, and dried to obtain granules.

Embodiment 3

[0045] Example 3: Intervention test of the composition on rats with alcoholic liver injury

[0046] experimental method:

[0047] A total of 50 healthy pure-line Wistar rats, SPF / VAF grade, male, weighing 150g±20g, were purchased from the Animal Breeding Center of Peking University School of Medicine. The animals are generally in good condition, with shiny coats, normal feeding and activities. Raised in SPF level animal laboratory, the temperature was 24°C±1°C, and the relative humidity was 55%±15%.

[0048] After adaptive feeding for one week, the animals were randomly divided into 5 groups according to body weight, 10 in each group, followed by normal group (normal control), model group (alcohol control), low-dose group, middle-dose group, high-dose group, respectively Gastrointestinal administration of normal saline, 3.7g / kg / day alcohol, 3.7g / kg / day alcohol + 150mg / kg / day chamomile composition granules, 3.7g / kg / day alcohol + 300mg / kg / day chamomile grass Composition granu...

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Abstract

The invention discloses a composition capable of protecting the liver with chronic alcoholic liver damage. The composition comprises, by weight, 1-5 parts of Penthorum chinense Pursh extract, 0.5-1 part of oligochitosan, 1-2 parts of cordyceps polysaccharide and 1-2 parts of dextrin. A preparation method of the composition includes: separating the Penthorum chinense Pursh extract through macroporous resin, respectively using 1% sodium hydroxide and 95% ethanol for extracting, concentrating, then absorbing with the macroporous resin, respectively using deionized water, 20% ethanol and 40% ethanol to wash impurities absorbed in the resin, eluting with 80% ethanol, and then performing vacuum concentrating; mixing the Penthorum chinense Pursh extract concentrated solution with the oligochitosan, cordyceps polysaccharide and dextrin according to the weight to obtain slurry, spray drying to prepare into powder, using a fluidized bed method to prepare into particles, and drying to obtain granules. The granules can protect the liver of a rat with the chronic alcoholic liver damage.

Description

technical field [0001] The invention belongs to the field of functional food and medicine, and relates to a composition with a protective effect on chronic alcoholic liver injury and a preparation method comprising the preparation of the extract of C. chinensis and the extract, chitosan oligosaccharide and cordyceps polysaccharide. Background technique [0002] Preventing diseases through reasonable functional foods has always been a hot spot of concern. There are a large number of non-nutritive bioactive substances or phytochemicals in plant foods, which have a wide range of biological activities and the effects of promoting health and preventing diseases. Among them, phenolic acids and polysaccharides are very important ones, which have various physiological functions such as anti-oxidation, anti-inflammation, and regulation of blood lipids (Hu, 2003; Loo, 2003). [0003] In recent years, the number of people with chronic liver damage caused by long-term drinking in my cou...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61P39/06A61P37/04A61P29/00
CPCA61K9/1652A61K31/722A61K36/068A61K36/185A61K2236/33A61K2236/51A61K2236/55A61K2300/00
Inventor 林强杨小方崔玉梅
Owner BEIJING UNION UNIVERSITY
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