Composition containing sulfasalazine and its application in preparation of medicine for treating ulcerative colitis

A technology for ulcerative colitis and sulfasalazine, which can be used in medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve problems such as leukopenia and limited clinical application.

Inactive Publication Date: 2017-12-29
薛会光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after oral administration of sulfasalazine at the prescribed dose, 10% to 40% of patients have adverse reactions such as nausea, indigestion, headache, and leukopenia, and occasionally cause arthralgia, rash, proteinuria, and pancreatitis. Clinical application is limited

Method used

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  • Composition containing sulfasalazine and its application in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Study on the Curative Effect of Sulfasalazine / Cinnamic Acid on Ulcerative Colitis Mouse Model

[0015] Fifty BALB / C male mice, aged 6-8 weeks, with a body weight of 20-24 g. All mice were randomly divided into the following five groups: normal control group, model control group, cinnamic acid group, sulfasalazine group, and cinnamic acid combined with sulfasalazine treatment group (combined drug group), with 10 mice in each group. All mice are used for experimental ulcerative colitis mouse model preparation after adaptive feeding 3d, promptly adopt dextran sodium sulfate gavage method to make ulcerative colitis mouse model: concentration is the dextran sulfate of 50g / L Sodium 0.8mL was administered orally, once a day, and at the same time, the aqueous solution containing 20g / L dextran sodium sulfate was freely drunk for 7 consecutive days.

[0016] From the next day after successful modeling, each group began to administer the enema, and the drug was prepared...

Embodiment 2

[0024] Example 2: Preparation of sulfasalazine / cinnamic acid enteric-coated tablets and capsules

[0025] Sulfasalazine 30g

[0026] Cinnamic acid 85g

[0027] Anhydrous sodium carbonate 5g

[0028] Polysorbate 80 8g

[0029] Hypromellose 60RT5 90g

[0030] Talc powder 100g

[0031] Triethyl citrate 20g

[0032] Polyacrylic resin emulsion L30D-55 500g

[0033] Preparation Process:

[0034] (1) Soak the hypromellose sodium 60RT5 of the prescribed amount in an appropriate amount of pure water, and dissolve it to make a 10% hypromellose solution for subsequent use;

[0035] (2) Weigh polysorbate 80 and anhydrous sodium carbonate and dissolve them in purified water respectively, and mix the polysorbate 80 solution and sodium carbonate solution under stirring. Take 10% hypromellose solution, add polysorbate 80 and sodium carbonate mixed solution into 10% hydroxypropyl methylcellulose solution under stirring, add a small amount of pure water to the above solution, and add it...

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Abstract

The invention discloses a medicine composition containing salazosulfapyridine and application of the composition in preparation of medicine for treating ulcerative colitis. The medicine composition can be an enteric-coated preparation orally taken, for example, enteric coated tablets and enteric coated capsules. The medicine composition can also be an external use preparation, for example, suppositories and intestinal juice. By means of the medicine composition, local hyperemia and edema of colon injuries can be obviously relieved, the inflammatory cell infiltration degree is decreased, the amount of anabrosis is decreased, and colon epithelium injury repair and anabrosis healing are promoted.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing sulfasalazine and its application in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis, also known as nonspecific ulcerative colitis, is a chronic inflammatory disease of the rectum and colon of unknown cause. The lesions are mainly located in the mucosal layer of the colon, and are mainly ulcers, mostly involving the rectum and distal colon, and can also spread throughout the colon. The main clinical symptoms are abdominal pain, diarrhea, blood in the stool, and diffuse, transmural inflammation and ulceration of the intestinal tract. The clinical diagnosis is confirmed by clinical indications, supplemented by colonoscopy and histopathological section observation. Patients with inflammatory bowel disease often show immune abnormalities, such as an increase in the nu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/655A61K31/192A61P1/00
CPCA61K31/192A61K31/655A61K2300/00
Inventor 薛会光杨爱华
Owner 薛会光
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