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Traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil and preparation method of traditional Chinese medicine composition

A technology of wild chrysanthemum and composition, which is applied in the field of traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil and its preparation, can solve the problems of low extraction rate, poor utilization effect, time-consuming inclusion rate, etc., and achieve high extraction rate , Improve bioavailability and prevent volatilization

Inactive Publication Date: 2016-04-13
宁夏金太阳药业有限公司
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  • Application Information

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Problems solved by technology

[0008] Although the above-mentioned documents and patents have reported the extraction of the volatile oil of chrysanthemum and wild chrysanthemum, they all extract a single medicinal material, and the extraction rate is not high, and the utilization effect is not good
[0009] In this study, the volatile oil extracted from chrysanthemum and wild chrysanthemum was included. Extraction and β-cyclodextrin inclusion complex preparation process) Although it is mentioned that the β-cyclodextrin inclusion is carried out on the volatile oil of the wild chrysanthemum, but the magnetic stirring method is used to encapsulate the volatile oil of a single medicinal material of the wild chrysanthemum. This method is not only time-consuming but also has a low inclusion rate

Method used

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  • Traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil and preparation method of traditional Chinese medicine composition

Examples

Experimental program
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Effect test

Embodiment 1

[0119] Weigh 150g of chrysanthemum and wild chrysanthemum respectively, pulverize, and pass through a 24-mesh sieve to obtain the coarse powder mixture of chrysanthemum and wild chrysanthemum. Put the coarse powder into a 1L extraction kettle, set the extraction pressure to 35MPa, extraction temperature to 35°C, separation kettle I pressure to 11MPa, temperature to 48°C; separation kettle II pressure to 8MPa, temperature to 36°C; carbon dioxide flow rate 11L / h, extract 60min after the instrument stabilizes, collect the extracts in the separation kettle I and the separation kettle II and merge and centrifuge the liquid, separate and remove the milky white lower layer liquid, get the supernatant to obtain the chrysanthemum wild chrysanthemum extract composition, the extraction composition yield is 4.26%. The ratio of the extract composition to β-cyclodextrin is 1:6, and the amount of water used is 4 times the weight of the extract composition, and inclusion is performed for 60 ...

Embodiment 2

[0121] Weigh 150g of chrysanthemum and wild chrysanthemum respectively, pulverize, and pass through a 24-mesh sieve to obtain the coarse powder mixture of chrysanthemum and wild chrysanthemum. Put the coarse powder into a 1L extraction kettle, set the extraction pressure to 30MPa, extraction temperature to 30°C, separation kettle I pressure to 10MPa, temperature to 45°C; separation kettle II pressure to 8MPa, temperature to 32°C; carbon dioxide flow rate 15L / h, extract for 120 minutes after the instrument stabilizes, collect the extracts in the separation kettle I and the separation kettle II and combine them with centrifugal separation, separate and remove the milky white lower layer liquid, take the supernatant to obtain the chrysanthemum wild chrysanthemum extract composition, and the yield of volatile oil is 4.02% . The ratio of the extract composition to β-cyclodextrin is 1:4, the amount of water used is 5 times the weight of the extract composition, and inclusion is car...

Embodiment 3

[0123] Weigh 150g of chrysanthemum and wild chrysanthemum respectively, pulverize, and pass through a 24-mesh sieve to obtain the coarse powder mixture of chrysanthemum and wild chrysanthemum. Put the coarse powder into a 1L extraction kettle, set the extraction pressure to 25MPa, extraction temperature to 30°C, separation kettle I pressure to 10MPa, temperature to 50°C; separation kettle II pressure to 7MPa, temperature to 35°C; carbon dioxide flow rate 13L / h, extract 90min after the instrument is stable, collect the extracts in the separation kettle I and the separation kettle II and merge and centrifuge the liquid, separate and remove the milky white lower layer liquid, take the supernatant to obtain the chrysanthemum wild chrysanthemum extract composition, and the yield of the volatile oil is 3.98 %. The ratio of the extract composition to β-cyclodextrin is 1:8, the amount of water used is 3 times the weight of the extract composition, and inclusion is carried out for 20 ...

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Abstract

The invention relates to traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil. Raw materials for preparation of the traditional Chinese medicine composition comprise chrysanthemums and wild chrysanthemums. The traditional Chinese medicine composition is prepared with a method as follows: (1) the chrysanthemums and the wild chrysanthemums are mixed uniformly in the weight ratio being 1:1, and a chrysanthemum and wild chrysanthemum mixture is obtained; (2) the mixture is added to an extraction kettle for supercritical extraction; a separation kettle is used for separation, and an extract is collected; (3) centrifugal liquid separation is performed, a milk white subnatant is separated, a liquid supernatant is taken, and wild chrysanthemum and chrysanthemum extraction composition is obtained; (4) the extraction composition, beta-cyclodextrin and water are subjected to inclusion with a colloid mill method. The traditional Chinese medicine composition has a remarkable effect on preparing a medicine for treating pharyngitis. The pharyngitis is chronic pharyngitis or acute pharyngitis, and the traditional Chinese medicine composition is particularly suitable for treating chronic pharyngitis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing chrysanthemum and wild chrysanthemum volatile oil and a preparation method thereof. Background technique [0002] Chrysanthemum (FlosChrysanthemi) belongs to the dry flower head of Compositae Chrysanthemum, and is one of the top ten famous flowers in China, while the traditional Chinese medicine Chrysanthemum is a perennial herb. The main components of chrysanthemum are volatile oil, flavonoids, amino acids, trace elements and so on. Cool in nature, sweet and bitter in taste, has the effects of calming the liver and improving eyesight, dispelling wind and relieving stagnation, tinnitus and insomnia, clearing heat and detoxifying, eliminating cough and relieving pain. Swelling poison, conjunctival congestion, dizziness, eye swelling and pain, etc. Li Shizhen once pointed out that "the seedlings can be use...

Claims

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Application Information

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IPC IPC(8): A61K36/287A61K47/48A61P11/04A61K47/69
CPCA61K36/287A61K2236/37A61K2300/00
Inventor 张军龙张启文马少平
Owner 宁夏金太阳药业有限公司
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