38results about How to "Treatment applicable" patented technology

The invention discloses a cold and hot probe device and particularly relates to a probe device for cold and hot combination therapy by electric heating and liquid nitrogen refrigerating, which is suitable for treating various solid tumors. The cold and hot probe device comprises a low-temperature pressure vessel, a low-temperature working medium, a booster, a low-temperature fluid valve, a low-temperature working medium transport tube, a handle, a probe pole, a probe head, an electric heating element, a temperature sensor, a data acquisition / control unit, a DC power supply module, a computer and the like. The invention can cool and heat the probe head conveniently so as to implement the cold and hot combination treatment and prevent normal tissues around the probe pole from being frozen and damaged in the cooling process. The invention has the advantages of simple structure, low cost, good controllability, high safety, convenient use and the like.

The invention relates to a device and a method for treating tumors through irreversible electroporation, belonging to the technical field of tumor treatment. The device mainly comprises a square wave pulse generation and measurement system, a signal conversion system, a man-machine communication system, a measurement control system and a power supply system. In the method, the device and a therapeutic electrode are used for treating the tumors through a program. Under the circumstance of no injection of chemotherapeutic drugs, microsecond square wave pulses are applied to tumor tissues, the entire tumor cell is fully damaged, so that the tumor cell dies due to irreversible electroporation, and the harm on the body of a patient caused by the side effect of the chemotherapeutic drugs is radically avoided. The invention has the characteristics of short treatment time, no pain, good treatment effect, high safety, convenient use, simple operation, convenient popularization and application and the like. The device and the method can be widely used for treating the tumors of human and animals, and are especially applicable to human tumor treatment.

The invention relates to a Chinese medicinal composition for treating lung cancer. The composition consists of an active ingredient or the active ingredient and a pharmaceutically acceptable carrier. The active ingredient is prepared from the following pharmaceutical ingredients: adenophora, asparagus root, dwarf lilyturf tuber, shizandra berry, American ginseng, unibract fritillary bulb, loquat leaves, barbed skullcap herb, astragalus, scorch-fried three immortals, powdered notoginseng root, arisaema cum bile, pinellia tuber, bamboo shavings, patrinia heterophylla Bge., bittersweet herb, common hongfennel root, Chinese paris rhizome and redroot gromwell root. The Chinese medicinal composition of the invention has the effect of clearing heat and resolving toxin, and eliminating blood stasis and detoxicating, is used for surgery and treatment after radiation treatment for lung cancer caused by accumulated toxin and blood-stasis obstruction, has no toxic or side effects, has an obvious treatment effect and a total effective rate of more than 95.0 percent, and is an ideal medicament for treating lung cancer.

The invention relates to the field of pharmaceutical formulation, and particularly to a traditional Chinese medicine decoction for treating colpitis mycotica. The traditional Chinese medicine decoction for treating the colpitis mycotica is characterized by comprising the raw medical materials in parts by weight of: 35-55 parts of golden cypress, 25-35 parts of radix sophorae flavescentis, 15-40 parts of glabrous greenbrier rhizome, 20-25 parts of sessile stemona root, 15-30 parts of common cnidium fruit, and 10-15 parts of Japanese knotweed. The six raw medical materials after being mixed are soaked in water; and slag is removed after the mixture is decocted to obtain filter liquor. The traditional Chinese medicine decoction is used for treating the colpitis mycotica, has remarkable effects on clearing heat and promoting diuresis, restraining and sterilizing bacteria, detoxicating and destroying intestinal worms, and relieving itching, is suitable for treating the colpitis mycotica, has no obvious side effect after being applied by a patient, and has a relatively high effective treatment rate.

The invention provides a short peptide for bacterium resisting, itching relieving, inflammation diminishing, swelling eliminating and scar removing, and its application. The short peptide fragment, analog, derivative and variant of the short peptide has an amino acid main sequence at least 70% homogeneous with and at least 90% similar to the main sequence of the short peptide; and the short peptide, nucleotides, the short peptide fragment, the short peptide analog, the short peptide derivative and the short peptide variant are used for preparing bacterium resisting, itching relieving, inflammation diminishing and swelling eliminating medicines for disinfecting all types of skins or treating the dermatopathy, or preparing medicines for locally treating the neurodermitis, contact dermatitis, chronic eczema, insect bite dermatitis and itching dermatopathy. The short peptide has the advantages of clear molecular structure, mature production technology, non-toxicity, innocuousness, no side effects, and no scars after curing, and is an excellent externally-used skin inflammation diminishing, swelling eliminating and itching relieving disinfectant or a dermatopathy treatment medicine.

The invention discloses a traditional Chinese medicine suppository for treating haemorrhoids. The traditional Chinese medicine suppository comprises a traditional Chinese medicine composition, vegetable oil and a matrix, wherein the traditional Chinese medicine composition includes, by weight, 0.6-2.0 parts of cortex phellodendri, 0.6-2.0 parts of rhizoma coptidis, 0.6-2.0 parts of radix scutellariae, 0.6-2.0 parts of radix et rhizoma rhei, 0.6-2.0 parts of honeysuckle flowers, 0.6-2.0 parts of radix sanguisorbae, 0.6-2.0 parts of galla chinensis and 0.3-1.0 part of borneol; the vegetable oil is colza oil, soybean oil and / or sesame oil; and the matrix is cocoa butter, acrawax and / or mixed fatty acid glyceride. The invention further discloses a preparation method for the traditional Chinese medicine suppository for treating haemorrhoids. The obtained traditional Chinese medicine suppository adopts the common traditional Chinese medicinal materials and is low in price, high in anti-infection performance, rapid in pain stopping and swelling removing speed, good in curative effect and suitable for treatment during an internal hemorrhoids operation and treatment after the internal hemorrhoids operation, and no toxic or side effect is caused.

The invention relates to certain 2-(2,4,5-substituted anilino)pyrimidine compounds as shown in a formula I which is described in the specification and an application thereof. The compounds or salts thereof exhibit higher inhibition to EGFR in an activated or drug-resistant mutant form than inhibition to wild-type EGFR. The toxicity associated with wild-type EGFR inhibition is reduced, so the compounds or the salts thereof are expected to have excellent pharmacodynamic properties, higher metabolic stability and better blood-brain barrier permeability, are more applicable to being used as a therapeutic agent, and are specifically applicable to being used for treatment of cancer. Therefore, the compounds or the salts thereof can be used for preparing medicines for treating EGFR-mediated diseases in certain mutant forms, especially medicines for non-small cell lung cancer.

The invention discloses traditional Chinese medicine paste for treating hemorrhoids. The traditional Chinese medicine paste comprises a traditional Chinese medicine composition, vegetable oil and a matrix. The traditional Chinese medicine composition comprises, by weight, 0.6 to 2.0 portions of phellodendron, 0.6 to 2.0 portions of coptis root, 0.6 to 2.0 portions of radix scutellariae, 0.6 to 2.0 portions of rhubarb, 0.6 to 2.0 portions of honeysuckle, 0.6 to 2.0 portions of radix sanguisorbae, 0.6 to 2.0 portions of Chinese gall and 0.3 to 1.0 portion of borneol. Vegetable oil is rapeseed oil, soybean oil or sesame oil. The matrix comprises one or more of albolene, beeswax, stearic acid, lanolin, hydrogenated vegetable oil, dimethicone, glycerol, gelatin, polyethylene glycol 4000 and polyethylene glycol 6000. The traditional Chinese medicine paste is prepared from common traditional Chinese medicines, has a cheap price, high infection resistance, a fast rate of eliminating swelling and alleviating pain, good curative effects and no toxic or side effect and is suitable for treatment on external hemorrhoid, internal hemorrhoid and mixed hemorrhoid and cure after a hemorrhoid operation.

The invention discloses a fully humanized single-chain antibody of targeted BCMA as well as a preparation method and application thereof. The single-chain antibody is formed by connecting a heavy chain variable region and a light chain variable region through a flexible connecting peptide, and the sequences of skeleton regions and CDR regions of the light chain and the heavy chain are derived from human, so that compared with murine and humanized antibodies, the single-chain antibody has higher specificity and lower immunogenicity; the specificity on BCMA is good; and a theoretical basis can be provided for treating diseases related to BCMA expression, and the method is particularly suitable for diagnosis and treatment of tumors such as multiple myeloma.

The invention discloses a traditional Chinese medicinal ointment for treating hemorrhoid. The traditional Chinese medicinal ointment for treating hemorrhoid comprises the following raw materials: a traditional Chinese medicine composition, a vegetable oil and a substrate, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 0.6-2.0 parts of Cortex Phellodendri, 0.6-2.0 parts of Rhizoma Coptidis, 0.6-2.0 parts of Rhizoma Polygoni Cuspidati, 0.6-2.0 parts of Radix Et Rhizoma Rhei, 0.6-2.0 parts of Flos Lonicerae, 0.6-2.0 parts of Radix Sanguisorbae, 0.6-2.0 parts of Galla Chinensis and 0.3-1.0 part of Radix Astragali. The vegetable oil is rapeseed oil, soybean oil and / or sesame oil; and the substrate comprises albolene, beeswax, stearic acid, lanolin, dimeticone, glycerine, gelatin and / or polyethylene glycol. The invention further discloses a preparation method of the traditional Chinese medicinal ointment for treating hemorrhoid. The obtained traditional Chinese medicinal ointment is prepared from common traditional Chinese medicinal materials, is low in price, high in anti-infection property, high in pain stopping and swelling subduing speed and good in curative effect, does not have toxic or side effects, and is suitable for treating external hemorrhoid, internal hemorrhoid, mixed hemorrhoid and postoperation of hemorrhoid.

The invention relates to the fields of traditional Chinese medicine science and medicines, and especially relates to a medicine for treating spondylodynia and hyperosteogeny, and a preparation method thereof. The medicine is an external preparation prepared from rhizoma drynariae, Achyranthes bidentata, panax notoginseng, Aconitum kusnezoffii and ginger, and preferably is a vinum, a paste, an ointment and a film agent. Clinical test confirms that the medicine has a very good therapeutic effect on hyperosteogeny, cervical spondylosis and various types of spondylodynia, and has the advantages of wide application range, safety in use, and very low treatment cost.

The invention relates to a device and a method for treating tumors through irreversible electroporation, belonging to the technical field of tumor treatment. The device mainly comprises a square wave pulse generation and measurement system, a signal conversion system, a man-machine communication system, a measurement control system and a power supply system. In the method, the device and a therapeutic electrode are used for treating the tumors through a program. Under the circumstance of no injection of chemotherapeutic drugs, microsecond square wave pulses are applied to tumor tissues, the entire tumor cell is fully damaged, so that the tumor cell dies due to irreversible electroporation, and the harm on the body of a patient caused by the side effect of the chemotherapeutic drugs is radically avoided. The invention has the characteristics of short treatment time, no pain, good treatment effect, high safety, convenient use, simple operation, convenient popularization and application and the like. The device and the method can be widely used for treating the tumors of human and animals, and are especially applicable to human tumor treatment.

The invention relates to the field of medicament formulation, in particular to a Chinese medicinal capsule for treating malignant lymphoma. Pinellia tuber, tangerine peel, radix ranunculi ternati, self-heal, mustard seed, wall lizard, polyporus umbellatus, fritillaria and oyster are used as raw materials; and the raw materials are cleaned, dried and ultramicro-crushed to reach the fineness of 400 meshes, the crushed raw materials are prepared into powder, and the powder is filled into capsules. The Chinese medicinal capsule is characterized in that the following raw materials by weight portion: 3 to 9 portions of the pinellia tuber, 3 to 9 portions of the tangerine peel, 9 to 15 portions of the radix ranunculi ternati, 9 to 15 portions of the self-heal, 3 to 9 portions of the mustard seed, 1.5 to 4.5 portions of the wall lizard, 6 to 18 portions of the polyporus umbellatus, 3 to 6 portions of the fritillaria and 15 to 30 portions of the oyster. The Chinese medicinal capsule has the remarkable efficacies of softening hardness and dissipating binds, reducing phlegm and resolving toxin, soothing liver and strengthening stomach, and supporting right qi, has no obvious toxic and side effect after a patient takes the capsule, is applicable to the treatment of the malignant lymphoma, and has high clinical yield.

The invention belongs to the field of traditional Chinese medicines and relates to a folium artemisiae argyi-containing traditional Chinese medicine formula for tonifying kidney yang and nourishing kidney yin. The traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 21-27 parts of folium artemisiae argyi, 19-26 parts of radix saposhnikoviae, 17-22 parts of poria cocos, 15-21 parts of radix achyranthis bidentatae, 16-22 parts of ligusticum wallichii, 10-16 parts of semen cuscutae, 9-15 parts of glossy privet fruit, 12-16 parts of angelica sinensis, 13-18 parts of cornus officinalis, 9-15 parts of lycium barbarum, 10-16 parts of ginger and 7-12 parts of liquorice. The traditional Chinese medicine formula provided by the invention has the functions of dredging channels and activating collaterals, activating blood and moving qi and tonifying and replenishing the liver and kidneys, and realizes a remarkable curative effect on kidney-deficiency syndrome. Animal experiments prove that the traditional Chinese medicine formula provided by the invention can remarkably improve the constitution and immunity of rats suffering the kidney-deficiency syndrome, and realizes a noticeable treatment effect on the rats suffering the kidney-deficiency syndrome.

The present invention relates to certain 2-(2,4,5-substituted anilino)pyrimidine compounds represented by the following formula I and applications thereof. These compounds or salts thereof show higher inhibition of EGFR in activated or drug-resistant mutant forms than in wild-type EGFR. Due to the reduced toxicity associated with wild-type EGFR inhibition, the compound or its salt is expected to have excellent pharmacodynamic properties, higher metabolic stability, better permeability of the blood-brain barrier, and is more suitable for use as a therapeutic agent, Especially suitable for the treatment of cancer. Therefore, these compounds or their salts can be used to prepare drugs for treating certain mutation forms of EGFR-mediated diseases, especially non-small cell lung cancer.

The invention relates to a Chinese medicinal composition for treating cancer and a preparation method thereof and belongs to the technical field of medicines. The Chinese medicinal composition for treating the cancer is mainly prepared from ten traditional Chinese medicines, namely radix sophorae flavescentis, aspongopus, capillary artemisia, curcuma zedoary, bamboo juice, uniflower swisscentaury root, rhizoma smilacis glabrae, corydalis tuber, lily and costustoot. The Chinese medicinal composition for treating the cancer has obvious inhibiting effect on growth of tumour, can be used for treatment of various cancers, is applicable to treatment on liver cancer patients and is especially applicable to advanced liver cancer patients.

The invention relates to the technical field of medicinal preparations, and concretely discloses a cisplatin-liposome preparation, and a preparation method and an application thereof. An improved formula and the improved method in the above technical scheme make the cisplatin liposome improve the bioavailability of cisplatin medicines and prolong the detention time of the medicines in bodies, and also make cisplatin be enriched in cancerous organs, thereby the dosage is reduced, curative effects are enhanced, the toxic and side effects of the medicines are reduced, and the medicines are suitable for treating various tumor diseases.

The invention relates to stomatological medicines, and particularly relates to a compound traditional Chinese medicine composition for treating parotitis. The compound traditional Chinese medicine composition for treating parotitis is prepared from the following components in parts by weight: 5-10 parts of saffron crocus, 5-10 parts of myrrh, 15-20 parts of lilac daphne flower bud roots, 15-20 parts of plantain herb, 10-15 parts of flowers carthami, 10-15 parts of fructus forsythiae, 10-15 parts of cactus, 15-20 parts of phaseolus calcaratus, 10-15 parts of the root barks of the peony trees, 3-5 parts of apiaries, 1-3 parts of scorpio and 5-10 parts of borneol. The invention further relates to a preparation method of the compound traditional Chinese medicine composition for treating parotitis as an external coating ointment. The compound traditional Chinese medicine provided by the invention has the advantages of good effect, quick effect, simple treatment method, no side effect and the like, is convenient to use, is suitable for treating parotitis caused by various causes, and is particularly suitable for treating mumps.

The invention provides an anti-BCMA antibody or an antigen binding fragment thereof, a chimeric antigen receptor containing the anti-BCMA antibody or the antigen binding fragment thereof, an immune cell and a drug. The invention also provides a preparation method and application of the anti-BCMA antibody or the antigen binding fragment thereof. The anti-BCMA antibody or the antigen binding fragment thereof prepared by the invention is a fully humanized single-chain antibody, has stronger specificity and lower immunogenicity, can specifically recognize and bind to BCMA positive target cells, and can provide a theoretical basis for treating diseases related to BCMA expression, so that the anti-BCMA antibody or the antigen binding fragment thereof can be applied to treatment and diagnosis of the diseases related to BCMA expression.

The invention discloses a Schlemm canal expansion stent which is in a one-way spiral shape. The outer diameter of the expansion stent is matched with the inner diameter of a Schlemm canal. The length of the expansion stent is matched with the length of the Schlemm canal. Or, the length of the expansion stent is matched with the length of the nidus of the Schlemm canal. The expansion stent can also be a secondary expansion stent. Or, the expansion stent is formed by connecting a plurality of secondary expansion stents in series. The Schlemm canal expansion stent is simple in structure, low in manufacturing process requirement, low in manufacturing cost, and beneficial for popularization and application. The Schlemm canal expansion stent is not only suitable for treatment of a late glaucoma patient, but also suitable for treatment of an early glaucoma patient and treatment of a secondary glaucoma patient.

The invention belongs to the technical field of medicine and relates to a Cu(DDC) 2 Nano-core liposome and its preparation method and application, specifically related to Cu(DDC) 2 Nano core liposome, its preparation method and its application in the preparation of medicine for treating liver cancer. The Cu(DDC) 2 Nanonuclear liposomes contain Cu(DDC) as an inner layer 2 Nanoparticles and the outer layer of phospholipids. The Cu(DDC) 2 Nanoparticles contain: CuCl 2 , sodium diethyldithiocarbamate (DDTC), and phospholipids, the weight ratio of each component is: (12‑51): (17‑68): (10‑20). The phospholipid layer comprises cholesterol, DSPE‑PEG 2000 , Phospholipids, Phospholipids, Cholesterol, DSPE‑PEG 2000 The mass ratio of is: (10‑20): (5‑10): (18‑42). The present invention prepares Cu(DDC) coated with phospholipids in the inner layer by reverse phase microemulsion polymerization 2 Nanoparticles, further by membrane hydration, encapsulate the outer layer of phospholipids. Cu(DDC) of the present invention 2 Nano-nuclear liposomes can significantly prolong the circulation time of drugs in the body and increase Cu(DDC) 2 antitumor effect.

The invention provides a short peptide for antibacterial, antipruritic, anti-inflammatory, detumescence, and scar removal and application thereof. The amino acid main sequence of the short peptide fragments, analogs, derivatives, and variants of the short peptide has ≥70% identity and ≥90% similarity with the short peptide amino acid main sequence; short peptides, nucleotides, short Peptide fragments, short peptide analogs, short peptide derivatives and short peptide variants are used for the preparation of antibacterial, antipruritic, anti-inflammatory and detumescent drugs for various skin disinfection or treatment of skin diseases, for the preparation of neurodermatitis, contact dermatitis, chronic eczema , Drug application for topical treatment of insect bite dermatitis and pruritic skin diseases. The short peptide involved in the invention has a clear molecular structure, mature production technology, and the finished product is non-toxic, harmless, and has no side effects. Its remarkable feature is that it does not leave scars after being cured.

The invention relates to a traditional Chinese medicine composition for treating chronic glomerulonephritis and a preparation method thereof. The traditional Chinese medicinal composition is prepared from the following raw materials: rehmannia glutinosa, yam, wolfberry, dogwood meat, dodder, tortoise board glue, antlers Gum, Polyporus, Poria, Bupleurum, Atractylodes, Guizhi, Cicada slough, windproof, Rhizoma Imperatae, Achyranthes. The traditional Chinese medicine composition for treating chronic glomerulonephritis has a reasonable composition, can achieve the effect of tonifying both yin and yang of the kidney, and the effect of tonifying the kidney is stable and lasting. While fundamentally treating the loss of nephrons in chronic glomerulonephritis, it can also effectively relieve symptoms such as proteinuria, hematuria, and hypertension.

The invention discloses traditional Chinese medicine gel for hemorrhoids. The traditional Chinese medicine gel is prepared from the following raw materials: a traditional Chinese medicine composition, vegetable oil and a base material; the traditional Chinese medicine composition is prepared from the following components in parts by weight: 0.6 to 2.0 parts of cortex phellodendri, 0.6 to 2.0 parts of rhizoma coptidis, 0.6 to 2.0 parts of rhizoma polygoni cuspidati, 0.6 to 2.0 parts of radix et rhizoma rhei, 0.6 to 2.0 parts of honeysuckle flower, 0.6 to 2.0 parts of radix sanguisorbae, 0.6 to 2.0 parts of nutgall and 0.3 to 1.0 part of radix astragali seu hedysari. The vegetable oil comprises rapeseed oil, soybean oil and / or sesame oil; the base material comprises beewax, polyethylene oxide, wool grease, gelatin and / or polyethylene glycol. The invention further discloses a preparation method of the traditional Chinese medicine gel for the hemorrhoids. The traditional Chinese medicine gel disclosed by the invention is made of common traditional Chinese medicines, has the advantages of cheap price, high infection resistance, rapid pain stopping and swelling eliminating effects, good curative effect and no toxic side effect, and is applicable to treatment of external hemorrhoids, internal hemorrhoids, mixed hemorrhoids and treatment after hemorrhoid surgeries.

The invention discloses a medicinal preparation for treating children's viral myocarditis. The medicinal preparation is prepared from the following raw materials in parts by weight: 30-40 parts of radix astragali, 20-30 parts of radix ophiopogonis, 15-20 parts of salvia miltiorrhiza, 10-15 parts of radix puerariae thomsonii, 10-15 parts of fructus akebiae, 15-25 parts of spina date seed, 12-25 parts of stigma croci, 8-12 parts of flos magnoliae officinalis, 5-10 parts of fructus choerospondiatis, 5-10 parts of lotus seed, 3-5 parts of perindopril and 6-10 parts of losartan. The invention further discloses a method for preparing the medicinal preparation. According to the medicinal preparation disclosed by the invention, components of traditional Chinese medicine and components of western medicine are combined, and the goal of treating both principal and secondary aspects of the disease is achieved; the treatment effect is good, and no toxic or side effect is generated.

The invention discloses an olmesartan medoxomil / rosuvastatin compound preparation and a preparation method thereof. The olmesartan medoxomil / rosuvastatin compound preparation is characterized by being prepared from a main drug and auxiliary materials, wherein the main drug is prepared from olmesartan medoxomil and rosuvastatin; the auxiliary materials comprise filler, a disintegrating agent, an adhesive, lubricant and a flow aid; the olmesartan medoxomil / rosuvastatin compound preparation is prepared through the process steps of raw material selecting, preparation, mixing, soft material preparing, pelleting, drying, particle finishing, total blending, finished product forming and the like. Olmesartan medoxomil is an ARB antihypertensive drug, has approximately-ideal pharmacological characteristics, and has an excellent antihypertensive effect. Rosuvastatin is a blood lipid regulating drug and is suitable for primary hypercholesterolemia (IIa type, including heterozygous familial hypercholesterolemia) or hybrid dyslipidemia (IIb type) with dyslipidemia incapable of being properly controlled through diet control and other non-drug treatment (such as sports therapy and weight losing). The compound preparation is formed by olmesartan medoxomil and rosuvastatin and is more suitable for treating patients with cardiovascular diseases, and the compliance of the patients is improved.

The invention relates to a traditional Chinese medicine composition for treating intestinal diseases of livestock and poultry. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15 to 25 parts of herba pteridis multifidae, 8 to 12 parts of senecio scandens, 8 to 12 parts of fructus chebulae, 10 to 20 parts of cortex fraxini, 5 to 10 parts of pericarpium granati and 25 to 35 parts of Chinese knotweed herb. The traditional Chinese medicine composition is an efficient and stable traditional Chinese medicine preparation for preventing and treating escherichia coli of the livestock and poultry, which is extracted from natural Chinese herbal medicines, so that the defects of crippling and teratogenesis which are caused by the conventional chemotherapy drug are overcome; the traditional Chinese medicine composition has an antibacterial function and a function of enhancing the immunity of organs, and is an ideal traditional Chinese medicine for preventing and treating the escherichia coli of the livestock and poultry.