A cu (ddc) 2 Nano core liposome and its preparation method and application

A nano-nucleus and liposome technology, which is applied in the field of medicine, can solve the problems of insignificant solubilization effect of surfactants, difficult preparation of physical and chemical properties, and poor fat solubility, so as to achieve reduced dosage, strong anti-tumor activity, and encapsulation high rate effect
CN111773183BActive Publication Date: 2022-02-01SHENYANG PHARMA UNIVERSITY
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2022-02-01

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of medicine and relates to a Cu(DDC) 2 Nano-core liposome and its preparation method and application, specifically related to Cu(DDC) 2 Nano core liposome, its preparation method and its application in the preparation of medicine for treating liver cancer. The Cu(DDC) 2 Nanonuclear liposomes contain Cu(DDC) as an inner layer 2 Nanoparticles and the outer layer of phospholipids. The Cu(DDC) 2 Nanoparticles contain: CuCl 2 , sodium diethyldithiocarbamate (DDTC), and phospholipids, the weight ratio of each component is: (12‑51): (17‑68): (10‑20). The phospholipid layer comprises cholesterol, DSPE‑PEG 2000 , Phospholipids, Phospholipids, Cholesterol, DSPE‑PEG 2000 The mass ratio of is: (10‑20): (5‑10): (18‑42). The present invention prepares Cu(DDC) coated with phospholipids in the inner layer by reverse phase microemulsion polymerization 2 Nanoparticles, further by membrane hydration, encapsulate the outer layer of phospholipids. Cu(DDC) of the present invention 2 Nano-nuclear liposomes can significantly prolong the circulation time of drugs in the body and increase Cu(DDC) 2 antitumor effect.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of medicine and relates to a Cu(DDC) 2 Nano-core liposome and its preparation method and application, specifically related to Cu(DDC) 2 Nano core liposome, its preparation method and its application in the preparation of medicine for treating liver cancer. Background technique

[0002] Primary liver cancer is a multiple tumor disease. Malignant tumors that occur on stem cells or bile duct cells of patients have a very high incidence rate, ranking the top six in cancer incidence, ranking fourth in incidence rate and third in mortality rate in my country, and have a great impact on human life and health , and frequently occurs, so it has certain harmfulness and seriously threatens people's life and health.

[0003] In terms of treatment methods, patients with early primary liver cancer tend to adopt surgical treatment, and the 5-year survival rate after surgery is 50% to 70%, but the tumor recurrence and met...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More