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Medicine composition with skin whitening and tendering functions and preparing method thereof

A technology for skin whitening and skin rejuvenation and a composition, applied in the field of medicine, can solve the problems of easy recurrence, inconvenient taking, low comfort, etc., and achieve the effects of no skin irritation, easy washing and removal, and good compatibility

Inactive Publication Date: 2016-04-20
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicine mainly includes oral administration and external therapy in the clinical treatment of pigmented spots. Among them, oral administration is mostly granules, capsules, pills or decoctions of compound preparations. Since the treatment period of pigmented spots is long and easy to relapse, therefore, Oral administration is inconvenient to take, as well as liver and kidney damage and certain gastrointestinal irritation
Commonly used external preparations include liniment, paste, ointment, ointment and other traditional dosage forms, which have the direct targeting effect of the drug to the lesion, and at the same time avoid the first-pass effect of oral administration, gastrointestinal irritation and the risk of liver and kidney damage. Therefore, patients have relatively high compliance with it; however, at present, more external preparations use crude extracts of Chinese herbal medicines, which have high impurity content, which is not conducive to the transdermal absorption and efficacy of active ingredients, and also Affects the appearance of the preparation and people's acceptance; the low level of the preparation makes the use process less comfortable, and cannot meet people's extremely high requirements for modern personal care products

Method used

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  • Medicine composition with skin whitening and tendering functions and preparing method thereof

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preparation example Construction

[0031] The preparation method of the above-mentioned pharmaceutical composition with whitening and rejuvenating effect comprises the following steps:

[0032] Step 1, weighing 0.5 to 5.0 parts of Baiji polysaccharide, 4.0 to 12.0 parts of seabuckthorn oil, 0.2 to 4.0 parts of α-arbutin, 0.5 to 4.0 parts of asiaticoside, 0.2 to 2.0 parts of angelica oil, 0.2-1.0 parts of jasmine oil, 0.05-0.15 parts of vitamin-E;

[0033] Step 2, add Baiji polysaccharides, total asiaticosides, α-arbutin, add 35-45 parts by mass of purified water, heat in a water bath at 60-70°C, and stir until Baiji polysaccharides are fully dissolved, set aside;

[0034] Step 3: Add 0.05 to 0.15 parts of preservative to 10.0 to 20.0 parts of humectant (the humectant is glycerin or propylene glycol or a mixture of glycerin and propylene glycol in any proportion), stir until evenly mixed, and heat in a water bath at 60 to 70°C , standby; the preservative is one of methylparaben, ethylparaben, propylparaben, but...

Embodiment 1

[0043] Step 1: Weigh 0.5 parts by mass of Baiji polysaccharide, 0.5 parts of asiaticoside, 4.0 parts of α-arbutin, add 35 parts by mass of purified water, and store at 60-70°C Heat in a water bath, and stir until the white and polysaccharides are fully dissolved, set aside;

[0044] Step 2: Weigh 0.05 parts by mass of preservative (chlorhexidine acetate) and add it to 10.0 parts by mass of glycerin, stir until evenly mixed, heat in a water bath at 60-70°C, and set aside;

[0045] Step 3: Weigh 1.0 parts by mass of Carbomer-934 and disperse it in purified water with 45 parts by mass, stir while adding, until Carbomer is fully dispersed in the water, set aside;

[0046] Step 4: Weigh 12.0 parts of seabuckthorn oil, 0.2 parts of angelica oil, 0.2 parts of jasmine oil, 0.05 parts of vitamin-E and 1.5 parts of stearic acid, heat in a water bath at 60-70°C, and set aside ;

[0047] Step 5: Add 2.5 parts by mass of triethanolamine to step 1 where the preheated white and polysacchar...

Embodiment 2

[0050] Step 1: Weigh 5.0 parts of Baiji polysaccharide, 4.0 parts of asiaticoside, 0.2 part of α-arbutin, add 45 parts of purified water, and store at 60-70°C Heat in a water bath, and stir until the white and polysaccharides are fully dissolved, set aside;

[0051] Step 2: Weigh 0.15 parts by mass of preservative (methylparaben) and add it to 20.0 parts by mass of glycerin, stir until evenly mixed, heat in a water bath at 60-70°C, and set aside;

[0052] Step 3: Weigh 0.25 parts by mass of Carbomer-934 and disperse it in purified water with 35 parts by mass, stir while adding, until Carbomer is fully dispersed in the water, set aside;

[0053] Step 4: Weigh 4.0 parts of seabuckthorn oil, 2.0 parts of angelica oil, 1.0 part of jasmine oil, 0.15 parts of vitamin-E and 0.5 parts of stearic acid, heat in a water bath at 60-70°C, and set aside ;

[0054] Step 5: Add 1.5 parts by mass of triethanolamine to step 1 where the preheated white and polysaccharides are fully dissolved, ...

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Abstract

The invention discloses a medicine composition with skin whitening and tendering functions and a preparing method thereof. The medicine composition is mainly prepared from, by mass, 0.5-5.0 parts of rhizoma bletillae polysaccharide, 4.0-12.0 parts of sea buckthron oil, 0.2-4.0 parts of alpha-arbutin, 0.5-4.0 parts of centella asiatica total glycosides, 0.2-2.0 parts of radix angelica oil, 0.2-1.0 part of jasmine oil and 0.05-0.15 part of vitamin E. Active portions or components of natural medicine are adopted as the skin whitening and tendering medicine composition, hydrogel type emulsion is adopted as a medicine delivery carrier, and the medicine composition is externally used for treating pigmented spots, has the targeted medicine delivery function that the medicine active components reach a nidus directly and has the functions of whitening skin, fading spots, resisting wrinkle, improving elasticity, resisting ageing and preventing rhagades on skin.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular relates to a pharmaceutical composition with whitening and skin rejuvenating effects, and also relates to a preparation method of the pharmaceutical composition. Background technique [0002] When the pigment is deposited on the local skin, especially the skin on the face, pigment spots such as freckles and brown spots will occur. Pigmented spot is a chronic skin pigmentation disorder disease, which often occurs in women's facial skin. Although there is no other special uncomfortable physiological reaction, it seriously affects people's appearance and image, and it is easy to make people negative, pessimistic and lost. Psychology, and then affect people's work, life and learning conditions, and even life and health. Modern medicine believes that the pathogenesis of pigmented spots is relatively complicated. It is generally believed that its formation is related to work pressure, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/107A61K9/06A61K36/63A61P17/16A61P17/18A61K31/355A61K31/715A61K31/7034
CPCA61K36/898A61K9/0014A61K9/06A61K9/107A61K31/355A61K31/7034A61K31/715A61K36/185A61K36/23A61K36/232A61K36/63A61K2300/00
Inventor 李伟泽赵宁赵茜王玉娥付丽娜韩文霞周永强
Owner XIAN MEDICAL UNIV
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