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A kind of polylactic acid-based antibacterial slow-release composite coating and preparation method thereof

A polylactic acid-based, composite coating technology, applied in coatings, pharmaceutical formulations, prostheses, etc., can solve the problems of being difficult to load on the surface of implants, prolonging the action time of drugs, and not being able to instantly inhibit bacteria. Beneficial for adsorption, reduced infection risk, and low cost

Active Publication Date: 2018-11-20
DABO MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent application number: CN201310593357.0 (publication number: CN103585113A), which discloses "a kind of apigenin polylactic acid sustained-release ball and its preparation method". Prolong the action time of the drug and improve the curative effect of the drug, but its shape is spherical, it is difficult to load on the surface of the implant, and it can only be delivered to the host by oral administration. It remains in the body for a long time in a spherical shape, so the expected effect of the experiment cannot be achieved
[0005] Although many patents and literatures have reported the application of polylactic acid as a drug relief packaging agent, most of them are prepared in the form of microspheres and preparations, which indeed have good antibacterial and sustained release properties, but they cannot be applied In human joint replacement, preparations and microspheres can only deliver antibiotics to the surroundings of the host through blood circulation, and cannot directly play a role at the host site. Joint replacement is a high-risk period of infection during and early in the operation. Preparations And microspheres can only play a certain role in the later stage of the operation, so it is extremely important to be able to load a coating with long-term antibacterial ability on the surface of the implant material

Method used

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  • A kind of polylactic acid-based antibacterial slow-release composite coating and preparation method thereof
  • A kind of polylactic acid-based antibacterial slow-release composite coating and preparation method thereof
  • A kind of polylactic acid-based antibacterial slow-release composite coating and preparation method thereof

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preparation example Construction

[0036] The invention provides a preparation method of a polylactic acid-based bacteriostatic slow-release composite coating, which comprises the following steps:

[0037] Step 1. Add polylactic acid into the organic solvent and stir until completely dissolved, wherein the mass fraction of the polylactic acid is 5%-12%. In this step, the organic solvent is dimethyl sulfoxide (DMSO), ethyl acetate, or acetone. The polylactic acid is L-PLA with a molecular weight of 50,000-100,000 or racemic polylactic acid D,L-PLA with a molecular weight of 50,000-100,000.

[0038] Step 2: Add a toughening agent into the above organic solvent and stir until it is completely dissolved, wherein the added amount of the toughening agent is 5-10% of the mass of the polylactic acid. In this step, the toughening agent is one or more of polyethylene glycol, polyvinylpyrrolidone and polyacrylate. Wherein, the polyethylene glycol has a molecular weight of 10,000-20,000, the polyvinylpyrrolidone has a mo...

Embodiment 1

[0047] Step 1) Pretreatment of titanium substrate

[0048] (1) Mechanical grinding: Polish a 1×1 cm titanium plate with 230-mesh, 1000-mesh, and 2000-mesh sandpaper until the surface is bright without scratches.

[0049] (2) Degreasing: The polished titanium plate was ultrasonically cleaned in acetone, ethanol and deionized water for 20 min, and then taken out and placed in a blast drying oven for drying.

[0050] (3) Coupling: Under the condition of heating at 60°C, place the degreased titanium plate in a ratio (volume ratio) of absolute ethanol: water: citric acid: isopropyl tri(dioctyl phosphate acyloxy base) titanate = 96:1:1:2 coupling agent solution, soak for 2 h for coupling treatment, take it out and dry it in a blast drying oven at 60°C for later use.

[0051] Step 2) Preparation of antibacterial slow-release coating solution

[0052] Dissolve 0.75 g of L-PLA (molecular weight 50,000) in 15 mL of dimethyl sulfoxide (DMSO) organic solvent, stir and dissolve to form a...

Embodiment 2

[0063] Step 1) Pretreatment of titanium substrate

[0064] (1) Mechanical grinding: Polish a 1×1 cm titanium plate with 230-mesh, 1000-mesh, and 2000-mesh sandpaper until the surface is bright without scratches.

[0065] (2) Degreasing: The polished titanium plate was ultrasonically cleaned in acetone, ethanol and deionized water for 20 min, and then taken out and placed in a blast drying oven for drying.

[0066] (3) Coupling: Under the condition of heating at 60°C, place the degreased titanium plate in a ratio (volume ratio) of absolute ethanol: water: citric acid: isopropyl tri(dioctyl phosphate acyloxy base) titanate = 96:1:1:2 coupling agent solution, soak for 2 h for coupling treatment, take it out and dry it in a blast drying oven at 60°C for later use.

[0067] Step 2) Preparation of antibacterial slow-release coating solution

[0068] Dissolve 1.2 g of L-PLA (molecular weight 80,000) in 15 mL of dimethyl sulfoxide (DMSO) organic solvent, stir and dissolve to form an...

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Abstract

The present invention provides a polylactic acid-based antibacterial slow-release composite coating and a preparation method thereof. The coating comprises the following components by weight: 5%-12% of polylactic acid, 0.25%-1.2% of a plasticizer, 5%-10% of antibiotics, and the balance of an organic solvent. The method is as below: adding polylactic acid into the organic solvent, and stirring fully until complete dissolution; adding a toughener in the organic solvent, and fully stirring until complete dissolution; adding antibiotics to the solution obtained in step S2, heating, stirring, conducting ultrasonic dispersion until complete dissolution to obtain a polylactic acid-based antibacterial slow-release liquid; and coating the slow release liquid to the surface of the substrate and drying to form a coating. The preparation process of the composite coating is simple, low in cost, high in biological activity and biodegradable; and the coating has a strong antimicrobial activity on staphylococcus aureus, and cumulative release time of up to 68 days.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a long-acting polylactic acid-based antibacterial slow-release composite coating and a preparation method thereof. Background technique [0002] Titanium implants are widely used because of their elastic modulus close to that of bone, non-magnetic properties, low density, specific strength, excellent chemical stability, and good biocompatibility. Periprosthetic infection has always been a serious complication in human joint replacement surgery, because biofilm is easily formed on the surface of the implant and the immunity between the implant and the tissue interface is poor. After the biofilm is formed, bacteria are on the surface Adhesion, growth and proliferation, once the bacteria adhere to the surface of the biofilm, it is difficult to be attacked by antibacterial agents and the human immune system, thereby causing human infection. Therefore, the key to inhibiting infecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54
CPCA61L27/34A61L27/54A61L2300/406A61L2300/606A61L2400/18C08L67/04
Inventor 陈艳文杜瑞红林志雄
Owner DABO MEDICAL TECH CO LTD