A preparation method of a microreactor for controllable screening of particles in fluids

Abstract

A method for preparing a microreactor for controllable screening of particles in a fluid, first manufacturing a polymer separation film with a micron-scale conical flask-shaped hole array, and obtaining a masking layer in the region of the micron-sized conical flask-shaped hole array through a covering process; Then microwave the polymer separation film to remove the masking layer; then realize the bonding of the upper polymer separation film and the lower polymer separation film, and apply pressure on the area of ​​the separation film outside the micron-scale conical flask-shaped hole array area to obtain a film system Install an air control system at both ends of the film system to obtain a microreactor; finally, by adjusting the flow rate and retention time of the air control system for inflation and exhaust, the regularity of the micron-sized conical flask-shaped holes on the separation film in the microreactor is obtained. The shrinkage of the microreactor realizes the active capture of particles in the screening fluid. The microreactor prepared by the present invention greatly improves the screening efficiency and scope of application of the microreactor, and realizes the screening and separation of different particles.

Description

technical field [0001] The invention belongs to the technical field of micro-nano manufacturing, and in particular relates to a preparation method of a micro-reactor for controllable screening of particles in a fluid. Background technique [0002] With the development of miniaturization technology, many microsystems have been applied to chemical industry, biomedicine, integrated electronic circuits and other fields, and have important application prospects. In recent years, the concept of microreactors has also been proposed. Different from chemical reactors in the conventional sense, microreactors are not general specific mechanical devices. , including highly integrated micro-reaction systems applied to various functions such as heat exchange, mixing and separation. Microreactors are usually micro-nano materials or substances with micro-nano structures, which provide a space at the micro-nano scale, so that the reaction is limited within the tiny space. By controlling the...

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Problems solved by technology

The disadvantage of this separation method is that it needs to introduce magnetic particles, and it is carried out in a high gradient magnetic field, and the selectivity to particles is high.

[0005] At present, in the research reports on the separation and screening of particles related to such microreactors, the following problems exist in the process of screening particles in microreactors: they need to rely on external forces to manipulate particles, and cannot actively screen particles; The characteristics of the separated particles are affected; there are restrictions on the characteristics of the separated particles and liquid medium; other materials need to be introduced, etc.

These problems limit the use range, purity and screening efficiency of microreactors to screen and separate particles

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