Compound and preparation method thereof

A technology of compounds and base catalysts, applied in the field of active compounds and their preparation, can solve problems such as inability to meet the needs of medicines, and achieve the effects of reducing toxicity and achieving good effects

Inactive Publication Date: 2016-05-11
BEIJING YISHENGTANG MEDICAL TECH RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, with the evolution of diseases, problems such as virus resistance and body drug resistance, new drugs developed simply by relying on

Method used

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  • Compound and preparation method thereof
  • Compound and preparation method thereof
  • Compound and preparation method thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0047] Example 1

[0048] An example of the compound of the present invention, the chemical structural formula of the compound in this example is as attached figure 1 As shown, the compound described in this example was prepared by the following preparation method:

[0049] (1) Put the compound of formula (6) in a dry and clean three-necked flask, add HEPT, the molar ratio of the HEPT to the compound of formula (5) is 5:1, heat and reflux in an electric mantle, at a temperature of 50~ The reaction was carried out at 400°C, and the reaction process was monitored by HPLC, and the reaction was stopped until the raw material basically reacted completely or the product no longer increased. When the temperature drops below 120°C, add pure ice water while stirring, place it in the refrigerator for crystallization (the temperature is about 0°C), filter, wash, and dry after crystallization to obtain the formula (1) Compound; In this step, the yield of the compound of formula (1) obtained i...

Example Embodiment

[0053] Example 2

[0054] An example of the compound of the present invention, the chemical structural formula of the compound in this example is as attached figure 1 As shown, the compound described in this example was prepared by the following preparation method:

[0055] (1) The compound of formula (6) is placed in a dry and clean three-necked flask, and DMAC is added. The molar ratio of the DMAC to the compound of formula (5) is 6:1. The reaction is heated and refluxed in an electric mantle at a temperature of 50~ The reaction was carried out at 400°C, and the reaction process was monitored by HPLC, and the reaction was stopped until the raw material basically reacted completely or the product no longer increased. When the temperature drops below 120°C, add pure ice water while stirring, place it in the refrigerator for crystallization (the temperature is about 0°C), filter, wash, and dry after crystallization to obtain the formula (1) Compound; In this step, the yield of the ...

Example Embodiment

[0058] (4) Add the compound of formula (4) obtained in step (3) into a clean three-necked flask, add acetone, the molar ratio of the acetone to the compound of formula (4) is 9:1, stir evenly and add formula ( 2) the compound, continue to stir, slowly add potassium hydroxide, the molar ratio of the potassium hydroxide to the compound of formula (4) is 15:1, then add benzyltriethylammonium bromide, and react at 25°C for 20 When the reaction process was monitored by HPLC, a new peak was generated. It was confirmed by mass spectrometry that a peak with a molecular weight of 960, 961, 962 (the same isotope peak, superimposed) was generated, which is the compound of the present invention. The molecular structural formula is as formula (5), and is further refined by extraction, reflux, recrystallization and other methods to obtain the compound of the present invention with higher purity. Example 3

[0059] An example of the compound of the present invention, the chemical structural fo...

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Abstract

The invention discloses a compound. The compound is prepared from berberrubine and magnolol through two times of nucleophilic substitution reactions under certain conditions. According to the compound, the inventor is guided by the traditional Chinese medicine pair theory and the traditional Chinese medicine clinical medication experience, berberrubine and magnolol are purposefully and selectively combined through a specific synthetic method, and the obtained compound has the effects of increasing the effect and reducing toxins, and has better effects on the aspects of inflammatory resisting, tumor resisting, cancer resisting, hyperglycemia and hyperlipidemia reducing, bacterium resisting, cardiovascular and cerebrovascular disease resisting and the like. Meanwhile, the invention discloses a preparation method of the compound and application of the compound in preparing medicine for treating tumors, cancer, hyperglycemia, hyperlipidemia and the cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a compound and a preparation method thereof, in particular to a compound with anti-inflammatory, anti-tumor, hypoglycemic and lipid-lowering, antibacterial and other effects and a preparation method thereof. Background technique [0002] Today, with the development of modern pharmacology, molecular biology and other theories and related science and technology, the ways and means of natural medicine development are constantly innovating. At present, there are roughly three ways to develop new drugs, namely the folk medicine way, the experience medicine way and the molecular way. Among them, with the development of molecular biology, genetics and information processing technology, molecular pathway has gradually become the main way to develop new drugs. However, based on the current national conditions of our country, and due to the limitations of technical equipment, at present, folk medicine and empirical medicine are the main...

Claims

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Application Information

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IPC IPC(8): C07D519/00C07D455/03A61P35/00A61P35/02A61P3/10A61P3/06A61P9/00A61P9/10A61P29/00A61P31/04A61P31/10
CPCC07D519/00C07D455/03
Inventor 李卫民冯毅凡朱贺年李铀张志朋
Owner BEIJING YISHENGTANG MEDICAL TECH RES CO LTD
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