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Medicament for dental ulcer and preparation method thereof

A technology for oral ulcers and medicaments, which is applied in the field of Chinese patent medicines, can solve problems such as improper storage and preservation, drug failure, and low content of active ingredients, and achieves the effects of enhancing the efficacy of drugs, saving equipment investment, and being simple to operate.

Inactive Publication Date: 2016-05-25
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a medicament for oral ulcers and a preparation method thereof, so as to solve the problem that the active ingredient content of the pharmaceutical preparation produced by the existing preparation method is low, the curative effect of the medicine cannot be fully exerted, and the medicine is damaged due to improper storage and preservation. Defects that reduce the content of the drug within the validity period and cause the drug to fail

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation method of medicine for oral ulcer:

[0024] (1) Take 420g of Atractylodes Rhizome, extract and collect the volatile oil with steam distillation, and collect the distillate and Atractylodes Rhizome residue for later use;

[0025] (2) Decoction of Atractylodes Rhizome dregs, 280g of gall seeds and 130g of licorice together with water, decocted for 2 hours with 8 times the weight of the medicinal material for the first time, and decocted with water 3 times the weight of the medicinal material for the second time After 1 hour, take two decoctions and filter the aqueous solution, and collect the filtrate;

[0026] (3) Combine the distillate and the filtrate, and measure an extract with a relative density of 1.15 to 1.20 g / ml when concentrated under reduced pressure to 50°C under vacuum -0.08MPa;

[0027] (4) Keep the concentrated extract at a temperature of 100°C under normal pressure, turn on the condensed water, reflux for 4.5 hours, continue to concentrate under reduc...

Embodiment 2

[0031] Preparation method of medicine for oral ulcer:

[0032] (1) Take 470g of Atractylodes Rhizome, extract and collect the volatile oil with steam distillation, and collect the distillate and Atractylodes Rhizome residue for later use;

[0033] (2) Decoction of herb residues of Atractylodes Rhizome, 320g of gall seeds and 180g of licorice together with water, decocted for 2 hours with 8 times the weight of the medicinal material for the first time, and decocted with water 3 times the weight of the medicinal material for the second time After 1 hour, take two decoctions and filter the aqueous solution, and collect the filtrate;

[0034] (3) Combine the distillate and the filtrate, and measure an extract with a relative density of 1.15 to 1.20 g / ml when concentrated under reduced pressure to 50°C under vacuum -0.08MPa;

[0035] (4) Keep the concentrated extract at a temperature of 100°C under normal pressure, turn on the condensed water, reflux for 3.5 hours, continue to concentrate ...

Embodiment 3

[0039] Preparation method of medicine for oral ulcer:

[0040] (1) Take 450g of Atractylodes Rhizome, extract and collect volatile oil with steam distillation, and collect the distillate and Atractylodes Rhizome residue for later use;

[0041] (2) Decoction of Atractylodes Rhizome dregs, 300g of gall seeds and 150g of licorice together with water, decocted for 2 hours with 8 times the weight of the medicinal material for the first time, and decocted with water 3 times the weight of the medicinal material for the second time After 1 hour, take two decoctions and filter the aqueous solution, and collect the filtrate;

[0042] (3) Combine the distillate and the filtrate, and measure an extract with a relative density of 1.15 to 1.20 g / ml when concentrated under reduced pressure to 50°C under vacuum -0.08MPa;

[0043] (4) Keep the concentrated extract at a temperature of 100°C under normal pressure, turn on the condensed water, reflux for 4 hours, continue to concentrate under reduced pre...

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Abstract

The invention provides a medicament for dental ulcer and a preparation method thereof. The medicament is prepared from main active pharmaceutical ingredients including Rhizoma atractylodis, gallnut, Radix glycyrrhizae and pearl according to a certain weight proportion through related steps of distillation collection and depressurization concentration. By using the medicament, the defect that due efficacy of medicinal preparations cannot be brought into full play due to the fact that the medicinal preparations produced by existing preparation methods are low in active ingredient content and the defect that the medicinal preparations loss efficacy caused by content decrease within period of validity due to improper storage are overcome. By using the preparation method, content of both gallic acid and glycyrrhizic acid can be improved remarkably, medicinal material resources are fully utilized, equipment investment for process improvement is saved, and operation is simple.

Description

Technical field [0001] The invention relates to a Chinese patent medicine medicament, in particular to a medicament for oral ulcers and a preparation method thereof. Background technique [0002] The conventional finished product quality standard of the drug for the treatment of oral ulcers only controls the active ingredient content of gallic acid in each bag (10g) not less than 0.25g. In order to improve the quality of the product and ensure the efficacy, it is planned to increase the content of the drug The content of the effective ingredients of licorice is controlled, that is, the content of licorice is not less than 4mg based on glycyrrhizic acid. In the conventional preparation method, the gallic acid content in gall can reach 0.29g on average, and the newly increased glycyrrhizic acid content occasionally The batches appear at the edge of the prescribed pass line, with an average value of only 4.8 mg. Within the 30-month validity period of their preparations, it may happe...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P1/02A61K36/284A61K35/64A61K35/618
CPCA61K36/284A61K9/1652A61K35/618A61K35/63A61K36/484A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 卿光明余定祥钟瑛
Owner SICHUAN MEDCO PHARML
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