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Metal medical device having lubricity and low protein adsorption properties and/or low cell adsorption properties, and method for producing same

A technology of metal medical devices and adsorption properties, which is applied in other medical devices, drug devices, pharmaceutical formulations, etc., can solve the problems of pain and tissue damage in patients with inflammation, improve durability, inhibit the deterioration of sliding properties, and inhibit low cell Effect of Deterioration of Adsorption Characteristics

Inactive Publication Date: 2016-06-01
SUMITOMO RUBBER IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When a medical device such as a guide wire or stent is inserted into the body in this condition, the medical device may damage tissues etc. in the body and cause inflammation or cause pain to the patient

Method used

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  • Metal medical device having lubricity and low protein adsorption properties and/or low cell adsorption properties, and method for producing same
  • Metal medical device having lubricity and low protein adsorption properties and/or low cell adsorption properties, and method for producing same
  • Metal medical device having lubricity and low protein adsorption properties and/or low cell adsorption properties, and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] The SUS guide wire (core wire) was washed with acetone and dried. The guide wire was dipped in a 10% by weight aqueous solution of SIM6492.57 (available from Gelest) for 30 minutes, then removed from it and left to stand at room temperature (25° C.) and 90% humidity for 24 hours. Thereafter the guidewire was rinsed with water and dried. The sliding properties of the resulting surface-treated guidewires were evaluated as described below.

Embodiment 2

[0162] The SUS guide wire (core wire) was washed with acetone and dried. The guide wire was dipped in a 10% by weight aqueous solution of SIB1824.84 (available from Gelest) for 30 minutes, then removed from it and left to stand at room temperature (25° C.) and 90% humidity for 24 hours. Thereafter the guidewire was rinsed with water and dried. The sliding properties of the resulting surface-treated guidewires were evaluated as described below.

Embodiment 3

[0164] The SUS guide wire (core wire) was washed with acetone and dried. The guidewire was dipped in a 10% by weight aqueous solution of SIT8402.0 (available from Gelest) for 30 minutes, then removed from it and left to stand at room temperature (25° C.) and 90% humidity for 24 hours. Thereafter the guidewire was rinsed with water and dried. The sliding properties of the resulting surface-treated guidewires were evaluated as described below.

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PUM

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Abstract

The present invention provides: a metal medical device such as a guide wire or a stent, the surface of which is imparted with lubricity and low protein adsorption properties and / or low cell adsorption properties by firmly bonding a lubricating layer to the surface of the metal medical device, and wherein the durability of the lubricating layer on the metal medical device surface is improved, thereby suppressing decrease in the lubricity and decrease in the low protein adsorption properties and / or in the low cell adsorption properties; and a method for producing this metal medical device. The present invention is a metal medical device having lubricity and low protein adsorption properties and / or low cell adsorption properties, the surface of said metal medical device being at least partially processed with a silane compound that has a functional group. This metal medical device is characterized in that the functional group is a polyoxyalkylene group, a metal salt-containing hydrophilic group, a halogen salt-containing hydrophilic group or a fluorine-containing hydrophobic group.

Description

technical field [0001] The present invention relates to metal medical devices with lubricity and low protein adsorption properties and / or low cell adsorption properties and methods for their production. Background technique [0002] A guidewire, stent, etc. is inserted and optionally placed in a blood vessel, airway, urethra, or other body cavity or tissue. When a medical device such as a guide wire or a stent is inserted into the body in this state, the medical device may damage tissues or the like in the body and generate inflammation or cause pain to the patient. In order to improve these problems, it is desired to improve the sliding properties of medical instruments to be inserted into the body. [0003] In addition, it is necessary to prevent as much as possible the adsorption of proteins and cells on the surface of stents etc. placed in the body for a long time, because the adsorption of proteins or cells on the surface can cause problems such as the formation of blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00A61L29/00A61M25/09
CPCA61L29/02A61L29/085A61L31/022A61L2400/10A61L31/10C08L27/12C08L83/04A61M2207/00
Inventor 皆川康久中下武文
Owner SUMITOMO RUBBER IND LTD
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