Building and evaluating method of chronic atrophic gastritis rat model

A technology of atrophic gastritis and rat model, which is applied in the direction of nuclear magnetic resonance analysis, etc., can solve the problems of high cost, time-consuming and laborious, and low accuracy of chronic atrophic gastritis model, and achieve a strong specific effect

Inactive Publication Date: 2016-06-08
SHANXI UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to solve the technical problems of low accuracy, high cost, time-consuming and laborious in the existing chronic atrophic gastritis model construction and evaluation methods, and to provide a chronic atrophic gastritis rat model construction and evaluation method

Method used

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  • Building and evaluating method of chronic atrophic gastritis rat model
  • Building and evaluating method of chronic atrophic gastritis rat model
  • Building and evaluating method of chronic atrophic gastritis rat model

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Experimental program
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Embodiment Construction

[0048] A construction method of chronic atrophic gastritis rat model, comprising the following steps:

[0049] Rats were freely fed with sodium deoxycholate solution with a concentration of 20mmol / L and ammonia solution with a concentration of 0.1% on one day and two days alternately, and sufficient amount was ensured; at the same time combined with the method of abnormal hunger and fullness: sufficient food for two days, and fasting for one day. Food, cycle implementation for 8 weeks.

[0050] A method for evaluating the chronic atrophic gastritis rat model constructed by the method described in this embodiment comprises the following steps:

[0051] 1) Metabolic profiles were characterized by multivariate statistical analysis methods, and principal component analysis (PCA) was used to perform pattern recognition on the data, and the separation of the data profiles of each group was investigated. The specific method is to collect the urine of the rat model respectively in th...

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Abstract

The invention belongs to the technical field of model building and evaluating methods, particularly relates to a building and evaluating method of a chronic atrophic gastritis rat model and mainly solves the technical problem that existing building and evaluating methods of the chronic atrophic gastritis rat model are low in accuracy, high in cost and time consuming and labor consuming. Technology of metabonomics is adopted, and a metabolic profile dynamic trajectory spectrum is acquired by analyzing changes in endogenous metabolite in organism end product urine before and after model building. In addition, MestReNova software is used to process all NR spectra to obtain integral data, statistical analysis on content of 18 biomarkers is combined, and a rule that changes in integral average value of the 18 biomarkers in the urine before and after model building reflect changing tendency of urine metabolic trajectory of rats with chronic atrophic gastritis to certain extent is found, so that the chronic atrophic gastritis model is evaluated in a targeted manner.

Description

technical field [0001] The invention belongs to the technical field of model construction and evaluation methods, and in particular relates to a construction and evaluation method of a chronic atrophic gastritis rat model. Background technique [0002] Chronic atrophic gastritis (CAG) is one of the common diseases of the digestive system, which refers to the reduction of intrinsic glands caused by repeated damage to the gastric mucosal epithelium, with or without fibrous replacement, intestinal gland metaplasia and / or pseudopyloric glands A chronic stomach disorder of metaplasia. In our country, CAG patients accounted for 13.8% of the total population examined. In 1978, the World Health Organization classified CAG as a precancerous state of the stomach. At present, modern medicine still lacks effective treatment methods for chronic atrophic gastritis. Once the patients get sick, it is difficult to cure, and most of them stay with the disease for life, which seriously thre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 刘月涛崔佳佳仝家羽胡英还秦雪梅杜冠华
Owner SHANXI UNIV
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