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Application of tranilast in preparation of drug for treating pyoderma gangrenosum

A tranilast and diabetes-based technology, which can be used in drug combinations and skin diseases, and can solve the problems of lack of specific and effective treatments

Inactive Publication Date: 2016-06-15
JIANGSU PROVINCE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no specific effective therapy for this disease

Method used

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  • Application of tranilast in preparation of drug for treating pyoderma gangrenosum
  • Application of tranilast in preparation of drug for treating pyoderma gangrenosum
  • Application of tranilast in preparation of drug for treating pyoderma gangrenosum

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] The following shows that tranilast can be used as a drug for treating diabetic scleredema through the specific clinical application of tranilast in the treatment of diabetic scleredema.

[0012] The used Tranister (trade name "Qukeshen", China Pharmaceutical University Pharmaceutical Co., Ltd.) has a specification of 100 mg per tablet.

[0013] Among the 3 patients, 2 were males in their 40s, and 1 was a female in their 60s. Both had suffered from type 2 diabetes for many years, and the medical history of diabetic scleredema was more than 5 years. B-ultrasound examination showed that the skin thickness increased to varying degrees. Tranilast Capsules 0.1 was given orally 3 times a day. After 3 months, the local skin erythema obviously subsided, became thinner, and became softer. figure 1 It is a B-ultrasound picture of a male patient in his 40s before taking the medicine (a and b are different parts of the affected skin). The B-ultrasound test found that the skin thickn...

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PUM

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Abstract

The invention discloses an application of tranilast in preparation of a drug for treating pyoderma gangrenosum. The tranilast is originally used for treatment of allergic diseases and keloid in clinic, is applied in clinic for many years, is a drug which is safe and effective and has less adverse reactions, is currently used in patients with pyoderma gangrenosum which has no clear treatment scheme in clinic; after the tranilast is applied for 3 months, symptoms can be observed to be obviously relieved in clinic, the thickness of skin is significantly thinner through B-ultrasonic examination, and no obvious adverse reactions exist. The drug is suggested to relatively quickly control skin damage of the patients with pyoderma gangrenosum, relieves clinical symptoms, has the advantages of good tolerance, relatively high patient compliance, rare adverse reactions, and relatively good clinical curative effect and safety.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of tranilast in the preparation of medicine for treating diabetic scleredema. Background technique [0002] Diabetic scleredema (pyodermagangrenosum, PG) is a rare disease characterized by diffuse symmetric skin sclerosis associated with diabetes. Most cases often occur in the back of the neck and shoulders with progressive, symmetrical and diffuse skin hardening, and some can extend to the face, front of the neck, scalp, chest, back and upper arms. Some cases can also involve the abdominal wall, buttocks and chest. The skin is substantially non-depressed and hard, the normal skin lines disappear, and the surface is red and the boundary with normal skin is unclear. The local feeling is as usual, and the degree of swelling and hardness is often the heaviest in the neck, shoulders and back, and it feels hard like skin when touched. If the neck is involved, it will be inco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/196A61P17/00
CPCA61K31/192A61P17/00A61K31/196
Inventor 侯麦花孙敏卢新政
Owner JIANGSU PROVINCE HOSPITAL
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