Application of tranilast in preparation of drug for treating pyoderma gangrenosum

Abstract

The invention discloses an application of tranilast in preparation of a drug for treating pyoderma gangrenosum. The tranilast is originally used for treatment of allergic diseases and keloid in clinic, is applied in clinic for many years, is a drug which is safe and effective and has less adverse reactions, is currently used in patients with pyoderma gangrenosum which has no clear treatment scheme in clinic; after the tranilast is applied for 3 months, symptoms can be observed to be obviously relieved in clinic, the thickness of skin is significantly thinner through B-ultrasonic examination, and no obvious adverse reactions exist. The drug is suggested to relatively quickly control skin damage of the patients with pyoderma gangrenosum, relieves clinical symptoms, has the advantages of good tolerance, relatively high patient compliance, rare adverse reactions, and relatively good clinical curative effect and safety.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of tranilast in the preparation of medicine for treating diabetic scleredema. Background technique [0002] Diabetic scleredema (pyodermagangrenosum, PG) is a rare disease characterized by diffuse symmetric skin sclerosis associated with diabetes. Most cases often occur in the back of the neck and shoulders with progressive, symmetrical and diffuse skin hardening, and some can extend to the face, front of the neck, scalp, chest, back and upper arms. Some cases can also involve the abdominal wall, buttocks and chest. The skin is substantially non-depressed and hard, the normal skin lines disappear, and the surface is red and the boundary with normal skin is unclear. The local feeling is as usual, and the degree of swelling and hardness is often the heaviest in the neck, shoulders and back, and it feels hard like skin when touched. If the neck is involved, it will be inco...

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