A kind of high-concentration iodine disinfectant and preparation method thereof

A disinfectant, high-concentration technology, applied in botany equipment and methods, disinfectants, pharmaceutical formulas, etc., can solve the problems of harming the normal secretion of human hormones, skin irritation, cumbersome preparation methods, etc., and achieve biological toxicity and adverse effects on the environment, no skin irritation, and simple preparation methods

Active Publication Date: 2019-06-28
ZHEJIANG HISUN ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the disinfectants with iodine as the main component include iodine tincture, iodophor, complex iodine disinfectant, povidone-iodine solution, etc., but the following disadvantages generally exist: low iodine concentration, between 0.1% and 1%, or cause The curative effect is insufficient; the stability is not good, and the validity period is between 0.5 and 2 years, such as polyethylene glycol iodine (PEG-I), polyvinyl alcohol iodine (PVA-I) and other complex iodine disinfectants; skin irritation Such as iodine tincture using ethanol as a solvent, iodine glycerin nipple infusion with ethanol content as high as 45%, etc.; the price is relatively expensive, and the production process conditions are relatively harsh, such as povidone iodine raw materials; the safety of the auxiliary materials and the smell of the product are unpleasant, and it is not easy to be farmed Due to the many defects of iodine preparations on the market, the application of iodine preparations in the dairy farming industry is greatly limited, especially in the prevention of mastitis in dairy cows.
Most of the iodine-related nipple dips and lotions approved by Canada on February 17, 2012 contain nonylphenol polyoxyethylene ether, while the Australian company’s product iodine kill ( Trade name: UDDERSAN) also uses this substance, the toxicity and carcinogenicity of mammals and aquatic organisms caused by this substance (LD50=1600mg / Kg, the EC50 to Daphnia is 42mg / L; the EC50 to algae is 50mg / Kg L); estrogen effect (can harm normal hormone secretion of human body, has spermicidal effect); biodegradation rate is slow, and the degradation rate is only 0% to 9%; (Mueller G C, Kim U. Displacement of estradiol from estrogen receptors by simple alkylphenols [J].Endocri.,1978,102(5):1429-1435.)
The formula of a kind of complex iodine solution disclosed in CN102335128A has quoted glycerin formal auxiliary material as auxiliary solvent, and this auxiliary material is highly toxic, corrosive, and smells bad, making it difficult for production personnel to accept it, and it is not easy to apply it at the same time. Accepted by farmers, it is difficult to promote this product in the market

Method used

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  • A kind of high-concentration iodine disinfectant and preparation method thereof
  • A kind of high-concentration iodine disinfectant and preparation method thereof
  • A kind of high-concentration iodine disinfectant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The disinfectant of this embodiment comprises the following components (unit: mass (g) and volume (ml) percentage)

[0040]

[0041] The method for preparing 100 liters of iodine disinfectant of the present invention: take 8 kg of nonionic surfactant fatty alcohol polyoxyethylene ether (C13 fatty alcohol+11EO) and add it to 10 kg of water and heat it to 50° C. After dissolving completely, add 2.5 kg of potassium iodide, 1.0 kg of Iodine, 2.0kg citric acid, heated while stirring at 50°C for 30 minutes to 1 hour until the iodine is completely dissolved to form a uniform solution, then add 5.0kg sorbitol, 0.5kg polyoxyethylene lanolin (PEG-75 wool Fat) stirring and dissolving, after cooling, add 10.0kg propylene glycol and surplus water, stir to obtain the described high-concentration iodine disinfectant, which can be used for body surface wound spray disinfection and nipple infusion.

Embodiment 2

[0043] The disinfectant of this embodiment comprises the following components (unit: mass (g) and volume (ml) percentage)

[0044]

[0045] The method for preparing 100 liters of iodine disinfectant of the present invention: take 50kg of nonionic surfactant fatty alcohol polyoxyethylene ether (C16 fatty alcohol+9EO) and add it to 10kg of water and heat it to 55°C. After dissolving completely, add 3.0kg potassium iodide, 3.0kg Iodine, 2.0kg hydrochloric acid, heated and stirred at 60°C for 30 minutes to 1 hour until the iodine is completely dissolved to form a uniform solution, then add 2.5kg sorbitol, 15.0kg glycerin and stir to dissolve, after cooling, add 1.0kg hydroxypropyl The methyl cellulose and the remaining amount of water are stirred evenly to obtain the high-concentration iodine disinfectant solution, which can be used for environment and milking machine disinfection.

Embodiment 3

[0047] The disinfectant of this embodiment comprises the following components (unit: mass (g) and volume (ml) percentage)

[0048]

[0049] The method for preparing 100 liters of iodine disinfectant of the present invention: take 70kg of nonionic surfactant propylene glycol block polyether (pluronic P105) and add it into 1kg of water and heat it to 60°C; , Stir while heating at 45°C for 30 minutes to 1 hour until the iodine is completely dissolved to form a uniform solution, then add 0.5kg polyoxyethylene lanolin (PEG-50 lanolin) and 1kg glycerin and stir to dissolve, add after cooling The remaining water is stirred evenly to obtain the high-concentration iodine disinfectant solution, which can be used for environment and milking machine disinfection.

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Abstract

The invention discloses a high-concentration iodine disinfection solution and a preparation method thereof. The high-concentration iodine disinfection solution is applicable to equipment and environment disinfection and skin tissue anti-bacterial disinfection, and particularly applicable to prevention and control over mastitis of animal nipples. The iodine disinfection solution is prepared from, by mass and volume, 1-5% of iodine, 0.5-20% of cosolvent, 8-90% of carrier non-ionic surfactant, 1.5-50% of emollient, 0.5-20% of pH adjusting agent and the balance water. The iodine disinfection solution has the advantages of being high in safety, efficient in disinfection, good in preservation stability, free of skin stimulation, easy to clean, free of yellow staining and the like. The preparation method is simple, stable and reliable in technology, short in preparation period and particularly suitable for industrial production, and has special requirement for equipment.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a high-concentration iodine disinfectant and a preparation method thereof. The disinfectant is suitable for disinfection of equipment and environments and antibacterial disinfection of skin tissues, and is especially suitable for disinfection of milking machines and nipple mastitis of milk-producing animals. prevention and treatment. Background technique [0002] Iodine disinfectant is a preparation made of iodine as the main bactericidal component. It is a kind of high-efficiency and broad-spectrum disinfectant that makes protein precipitate by free iodine element to play a bactericidal effect. It can quickly kill bacteria, spores, viruses, phages, Pathogens such as fungi. [0003] At present, the disinfectants with iodine as the main component include iodine tincture, iodophor, complex iodine disinfectant, povidone-iodine solution, etc., but the following disadvantages generally exist: low io...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K9/08A61K47/10A61P31/02A61P15/14A01N59/12A01N25/10A01P1/00A01P3/00
CPCA01N25/10A01N59/12A61K9/0014A61K9/08A61K33/18A61K47/34A01N2300/00
Inventor 谢等龙汪雪君骆红英王以跃陈国庆李贵玉白骅
Owner ZHEJIANG HISUN ANIMAL HEALTH PROD CO LTD
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