A kind of high-concentration iodine disinfectant and preparation method thereof

Abstract

The invention discloses a high-concentration iodine disinfection solution and a preparation method thereof. The high-concentration iodine disinfection solution is applicable to equipment and environment disinfection and skin tissue anti-bacterial disinfection, and particularly applicable to prevention and control over mastitis of animal nipples. The iodine disinfection solution is prepared from, by mass and volume, 1-5% of iodine, 0.5-20% of cosolvent, 8-90% of carrier non-ionic surfactant, 1.5-50% of emollient, 0.5-20% of pH adjusting agent and the balance water. The iodine disinfection solution has the advantages of being high in safety, efficient in disinfection, good in preservation stability, free of skin stimulation, easy to clean, free of yellow staining and the like. The preparation method is simple, stable and reliable in technology, short in preparation period and particularly suitable for industrial production, and has special requirement for equipment.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a high-concentration iodine disinfectant and a preparation method thereof. The disinfectant is suitable for disinfection of equipment and environments and antibacterial disinfection of skin tissues, and is especially suitable for disinfection of milking machines and nipple mastitis of milk-producing animals. prevention and treatment. Background technique [0002] Iodine disinfectant is a preparation made of iodine as the main bactericidal component. It is a kind of high-efficiency and broad-spectrum disinfectant that makes protein precipitate by free iodine element to play a bactericidal effect. It can quickly kill bacteria, spores, viruses, phages, Pathogens such as fungi. [0003] At present, the disinfectants with iodine as the main component include iodine tincture, iodophor, complex iodine disinfectant, povidone-iodine solution, etc., but the following disadvantages generally exist: low io...

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Problems solved by technology

[0003] At present, the disinfectants with iodine as the main component include iodine tincture, iodophor, complex iodine disinfectant, povidone-iodine solution, etc., but the following disadvantages generally exist: low iodine concentration, between 0.1% and 1%, or cause The curative effect is insufficient; the stability is not good, and the validity period is between 0.5 and 2 years, such as polyethylene glycol iodine (PEG-I), polyvinyl alcohol iodine (PVA-I) and other complex iodine disinfectants; skin irritation Such as iodine tincture using ethanol as a solvent, iodine glycerin nipple infusion with ethanol content as high as 45%, etc.; the price is relatively expensive, and the production process conditions are relatively harsh, such as povidone iodine raw materials; the safety of the auxiliary materials and the smell of the product are unpleasant, and it is not easy to be farmed Due to the many defects of iodine preparations on the market, the application of iodine preparations in the dairy farming industry is greatly limited, especially in the prevention of mastitis in dairy cows.

Most of the iodine-related nipple dips and lotions approved by Canada on February 17, 2012 contain nonylphenol polyoxyethylene ether, while the Australian company’s product iodine kill ( Trade name: UDDERSAN) also uses this substance, the toxicity and carcinogenicity of mammals and aquatic organisms caused by this substance (LD50=1600mg / Kg, the EC50 to Daphnia is 42mg / L; the EC50 to algae is 50mg / Kg L); estrogen effect (can harm normal hormone secretion of human body, has spermicidal effect); biodegradation rate is slow, and the degradation rate is only 0% to 9%; (Mueller G C, Kim U. Displacement of estradiol from estrogen receptors by simple alkylphenols [J].Endocri.,1978,102(5):1429-1435.)

The formula of a kind of complex iodine solution disclosed in CN102335128A has quoted glycerin formal auxiliary material as auxiliary solvent, and this auxiliary material is highly toxic, corrosive, and smells bad, making it difficult for production personnel to accept it, and it is not easy to apply it at the same time. Accepted by farmers, it is difficult to promote this product in the market

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