Column chromatography and membrane filtration integration system

An integrated system and column chromatography technology, applied in the direction of membrane technology, semi-permeable membrane separation, chemical instruments and methods, etc., can solve the problem of high cost, achieve cost saving, avoid pollution and inactivation, and shorten the process time.

Active Publication Date: 2016-06-22
宁波艾纯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of system only simply integrates several different modules through pipelines, and can only realize that all modules work in sequence according to the pipeline connection sequence, and the cost is relatively high

Method used

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  • Column chromatography and membrane filtration integration system
  • Column chromatography and membrane filtration integration system
  • Column chromatography and membrane filtration integration system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Such as figure 2 Shows the flow path connection where the mobile phase is first purified through the membrane module.

[0058] 1) Add the raw materials to be separated into the first storage tank FR1-1, open the first storage tank inlet valve IV1, the membrane module selection valve CV1, the first loop outlet valve OV4, the first exhaust outlet valve OV6, The second exhaust outlet valve OV8, the second loop outlet valve OV9, pump P1 quantitative raw material liquid, through the membrane module MM1 for sample filtration, the concentrated liquid enters the first liquid collection tank BT1, the permeate enters the second liquid collection tank BT2.

[0059] 2) After the liquid in the liquid collecting tank reaches a certain amount, close the inlet valve IV1-1 of the first liquid storage tank, open the inlet valve IV6 of the first liquid collecting tank, and carry out further circulation, concentration and filtration of the concentrated liquid. The final concentrate is obtaine...

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PUM

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Abstract

The invention relates to a bioengineering product separation and purification device and particularly relates to a column chromatography and membrane filtration integration system. The column chromatography and membrane filtration integration system comprises a column chromatography unit and a membrane filtration unit, wherein the two units use one pump and one detector. By virtue of switching the valve, an operation mode of sequentially performing membrane filtration and column chromatography and an operation mode of sequentially performing column chromatography and membrane filtration are realized, switching of the valve can be controlled by virtue of a computer, and automatic and full-closed operation of the device is realized.

Description

Technical field [0001] The invention relates to biological engineering product separation and purification equipment, in particular to an integrated system of column chromatography and membrane filtration to achieve the purpose of high-efficiency separation and purification. Background technique [0002] Column chromatography technology is a unit operation often used in modern chemical engineering and biochemical separation processes. For protein mixtures with complex components (such as plasma and enzymes), separation of effective components is difficult, the process is complicated, time-consuming, poor resolution, and low efficiency. In the separation process, the complementary separation and purification mode of chromatography column and membrane filtration is usually used. [0003] Traditional separation and purification methods require manual switching during sample pretreatment, column chromatography purification, membrane filtration and other stages, and they have to be ope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/10B01D63/08B01D63/02B01D63/00
CPCB01D15/10B01D63/00B01D63/02B01D63/08
Inventor 李秀男陈超赵大伟苏志国
Owner 宁波艾纯生物科技有限公司
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