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Micro-fluidic chip for generating spherical microbubbles

A microfluidic chip and microbubble technology, applied in the field of fluid machinery, can solve the problems of lengthy, cumbersome, difficult operation, etc., and achieve the effect of stable production process and wide controllable range

Active Publication Date: 2016-06-22
CHINA JILIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, in the process of using a microfluidic chip to prepare micron-scale bubbles, due to the limitation of the microchannel structure in the existing microfluidic chip, the process of obtaining microbubbles by controlling liquid and gas during the experiment is long, cumbersome, and difficult to operate. And the generated microbubbles are flat rather than three-dimensional spherical microbubbles

Method used

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  • Micro-fluidic chip for generating spherical microbubbles
  • Micro-fluidic chip for generating spherical microbubbles
  • Micro-fluidic chip for generating spherical microbubbles

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Embodiment Construction

[0016] like Figure 1-3 As shown, taking PDMS as an example of a microfluidic chip made of material, the specific embodiment of the present invention is:

[0017] Microfluidic chip, rectangular parallelepiped, 40mm long, 20mm wide, 5mm high, formed by bonding the first chip 6 and the second chip 7, microchannels are etched on the surface of the chip using photoetching technology, the first chip includes liquid injection Channels 1 and 3, channel width 30 μm, depth 20 μm, gas injection channel 2, channel width 40 μm, depth 20 μm, bevel design at the junction of liquid channels 1, 3 and gas channel 2, the included angle is 70°, microbubble generation channel 4 , the channel length is 40 μm, the channel width is 10 μm, and the depth is 10 μm. The side section of the microbubble generation channel can form a square with a side length of 10 μm. Microbubble output channel 5, the channel width is 100 μm, and the depth is 40 μm. The liquid channel, the gas channel and the microbubble...

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Abstract

The invention discloses a micro-fluidic chip for generating spherical microbubbles.The micro-fluidic chip is formed by bonding two chip bodies which are different in internal microchannel structure, and microchannels with certain thickness and width are etched in the bonding surface of each chip body through a photoetching technology.The first chip body is internally provided with two liquid microchannels, a gas microchannel, a microbubble generation channel and a microbubble output channel, and an included angle with a certain angle exists on the junction of each liquid microchannel and the gas microchannel; the second chip body is internally provided with liquid microchannels, a gas microchannel and a microbubble output channel which all have the same structural sizes as those of the first chip body, but the microbubble generation channel does not exist in the second chip body.After the two chip bodies are bonded to form the micro-fluidic chip, liquid and gas are injected into the microchannels simultaneously, and the microbubbles with different diameter sizes are generated by adjusting the liquid flow and controlling the gas pressure.According to the micro-fluidic chip for generating the spherical microbubbles, the limitation of the microbubbles generated by a micro-fluidic element on the aspects of structure and shape is broken through.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to a microfluidic chip for generating spherical micron-scale bubbles, which belongs to the field of fluid machinery. Background technique [0002] In recent years, micron-scale bubbles have been widely used in medicine, petroleum, environment, mining, chemical industry, power, metallurgy, nuclear energy and other fields due to their unique hydrodynamic properties and scale effect. Especially in the field of biomedicine, various microbubble-based ultrasonic measurement technologies, targeted drug delivery and gene-mediated therapy technologies have developed rapidly. The size and stability of the generated microbubbles will affect its application effect in various fields. Therefore, in-depth study of the formation mechanism and flow characteristics of microbubbles can lay the theoretical foundation for the practical application of microbubbles in many fields. [0003] With the in-depth resear...

Claims

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Application Information

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IPC IPC(8): B01F13/00B01L3/00
CPCB01L3/502707B01L3/502792B01L2400/0487B01L2300/0829B01L2300/0819B01L2300/0816B01L2300/0887B01L2300/0867B01L2200/025B01L2200/10B01L2200/0636B01F33/30121B01F33/3022B01F33/3034B01F2101/23
Inventor 包福兵项素娟凃程旭林建忠
Owner CHINA JILIANG UNIV
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