Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Yiganle tablet to preparation of drugs for inhibiting bladder squamous carcinoma cell SCaBER proliferation

A technology for cell proliferation and cancer cells, which is applied in the field of preparation of Yiganle tablets, and can solve problems such as rough process, affecting application, and many impurities

Inactive Publication Date: 2016-07-06
JINAN XINSHIDAI MEDICINE SCI & TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Yiganle tablets in the preparation of drugs for inhibiting the proliferation of SCaBER cells in human bladder squamous cell carcinoma cells, and there is no report on the use of supercritical extraction in the extraction and preparation of Yiganle tablets. The method of decocting in water and ethanol reflux extraction, the process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 200g of chicken vine, 160g of knotweed, 200g of verbena, 200g of June snow, 200g of maran grass, 200g of grass berry, 170g of auspicious grass, 100g of kungfu wood, 70g of cold water flower, and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 5% of the total extraction solvent, the extraction pressure is 25MPa, the temperature is 40°C, and CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 750min, and the supercritical extract is obtained. The supercritical extract is added to starch, 70% ethanol to make granules, dried, and pressed into 200 tablets, each weighing 0.30g.

[0025] After testing, the content of emodin in the finished product was 1.85mg / tablet.

Embodiment 2

[0027] Take 200g of chicken vine, 160g of knotweed, 200g of verbena, 200g of June snow, 200g of maran grass, 200g of grass berry, 170g of auspicious grass, 100g of kungfu wood, 70g of cold water flower, and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 900min, and the supercritical extract is obtained. The supercritical extract is added to starch, 70% ethanol to make granules, dried, and pressed into 200 tablets, each weighing 0.30g.

[0028] After testing, the content of emodin in the finished product was 1.21mg / tablet.

Embodiment 3

[0030] Take 200g of chicken vine, 160g of knotweed, 200g of verbena, 200g of June snow, 200g of maran grass, 200g of grass berry, 170g of auspicious grass, 100g of kungfu wood, 70g of cold water flower, and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 6% of the total extraction solvent, the extraction pressure is 30MPa, the temperature is 60℃, and CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch, 70% ethanol is used to make granules, dried, and compressed into 200 tablets, each weighing 0.30g.

[0031] After testing, the content of emodin in the finished product was 0.95mg / tablet.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to an application of a Yiganle tablet to preparation of drugs for inhibiting bladder squamous carcinoma cell SCaBER proliferation and a preparation method of the Yiganle tablet. The Yiganle tablet is prepared by using 200g of Chinese fevervine herb, 160g of giant knotweed rhizome, 200g of European verbena, 200g of snow of June herb, 200g of Chinese wedelia herb, 200g of rubus parvifolius, 170g of pink reineckea herb, 100g of Chinese mahonia stem and 70g of pilea notata as raw medicines and is prepared by adopting supercritical extraction, so that the content of emodin is greatly increased.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to an application of Yiganle tablets in preparing drugs for inhibiting the proliferation of bladder squamous cell carcinoma SCaBER cells and a preparation method of Yiganle tablets. Background technique [0002] The standard number of Yiganle Granules is WS-10148 (ZD-0148)-2002, which is recorded in the Internal Medicine Hepatobiliary Division of the National Standards of Chinese Patent Medicines. It is made of 200g chicken vine, 160g polygonum cuspidatum, 200g verbena, 200g June snow, 200g marlan grass, 200g berry, 170g auspicious grass, 100g of kungfu tree, and 70g of cold water flower as raw materials. The effect of. Used for acute and chronic hepatitis B caused by liver and gallbladder damp heat. [0003] In the prior art, there is no report on the application of Yiganle tablets in the preparation of drugs for inhibiting the proliferation of human blad...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/896A61K9/20A61P35/00
CPCA61K36/896A61K9/2059A61K36/185A61K36/28A61K36/282A61K36/29A61K36/41A61K36/47A61K36/704A61K36/73A61K36/74A61K36/85A61K2236/37A61K2300/00
Inventor 王静
Owner JINAN XINSHIDAI MEDICINE SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com