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A pharmaceutical carrier for skin wound drug delivery and its preparation method and application

A skin and compound technology, applied in the field of acrylate acetylglucosamine compounds and their preparation, can solve the problems of increasing the workload of doctors, skin damage, slow granulation growth and the like

Active Publication Date: 2019-03-12
天津市医药科学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Full-thickness skin defect caused by severe trauma, extensive burns and other reasons is one of the common clinical diseases. The traditional treatment method is to change the dressing after wound debridement, and then perform skin grafting or skin flap surgery to close the wound after the wound granulation tissue grows well. , the traditional dressing treatment of granulation growth is slow, and it takes a long time to achieve wound healing, which often brings great pain to patients and increases the workload of doctors. Therefore, in the treatment of burns, wound dressings are needed to promote healing. Rapid wound healing
[0006] 3. radiation skin damage
[0009] Wound dressings are mainly divided into traditional dressings and biological dressings. Although various biological dressings have good performance in one aspect, they all have more or less defects. There is no cheap dressing with good performance. At present, there are three main directions in the research of biological dressings: improving wound healing by adding substances that can accelerate healing and reduce scars; researching skin substitutes that perform like autologous skin; researching related proteins that can promote skin healing, ideally Wound dressings can not only prevent body fluid loss, control water evaporation, and inhibit bacterial infection; but also promote adhesion to wounds and promote tissue growth, thereby making up for the lack of a single dressing

Method used

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  • A pharmaceutical carrier for skin wound drug delivery and its preparation method and application
  • A pharmaceutical carrier for skin wound drug delivery and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Synthesis of Acrylate Acetyl Glucosamine.

[0027] Dissolve 1.221g, 5.5mmol N-acetylglucosamine in 6.00 mL dimethylacetamide solution, and add 150mg lithium chloride at 80°C. Cool to room temperature and add 3.1 mL, 22 mmol triethylamine, cool to 0°C and add 3.56 ml, 44 mmol acryloyl chloride dropwise, stir at room temperature overnight, monitor the reaction by thin-layer chromatography, dilute with diethyl ether after the reaction, and filter off the solid. Wash the filtrate 3 times with saturated brine, dry the organic phase, concentrate in vacuo, and separate by column chromatography (eluent ratio: dichloromethane / methanol = 40 / 1).

Embodiment 2

[0029] Structural characterization of acrylate acetylglucosamine.

[0030] The molecular formula for Acrylate Acetyl Glucosamine is C 20 h 23 NO 10 , the molecular weight is 437.1322. The molecular weights of the synthesized compounds were detected using high-resolution mass spectrometry. Estimate compound results as HRMS-ESI (m / z): C 20 h 23 NO 10 Na

[0031] [M+Na] + =460.14. A chromatographic peak with a molecular weight of 460.13 was found in the detection results of high-resolution mass spectrometry, which was identified as acetyl glucosamine acrylate within the allowable error range.

[0032] Hydrogen Spectrum of Acrylate Acetyl Glucosamine, Analysis Results: 1H NMR (400 MHz, DMSO) δ 8.34 –8.01 (m, 1H), 6.51 (dd, J = 24.2, 14.5 Hz, 1H), 6.44 – 6.25 (m, 5H), 6.24 –6.15 (m, 2H), 6.16 – 6.01 (m, 5H), 6.02 – 5.89 (m, 4H), 5.91 – 5.79 (m, 1H),5.46 – 5.30 (m, 1H), 5.20 ( dd, J = 19.8, 10.3 Hz, 1H), 4.58 (dd, J = 16.3,9.7 Hz, 1H), 4.52 – 4.35 (m, 1H), 4.33 – 4.07 (m,...

Embodiment 3

[0034] Biocompatibility of acrylated acetylglucosamine.

[0035] Cut the acrylate acetylglucosamine polymer into discs with a diameter of 10 mm and a thickness of about 1 mm. The negative control is a high-density polyethylene disc with a diameter of 10 mm, and the positive control is a polyethylene disc with a diameter of 10 mm coated with dioctyl phthalate. Vinyl chloride discs. In the experiment, mouse fibroblast L-929, which has been vigorously grown for 48 hours, was selected, and the prepared 3×10 5 ·ml -1 The cell suspension was inoculated in 90mm dishes, 10ml per dish, 3 dishes in total. Discard the culture solution after 24 hours, mix 3% agar and 2 times concentration culture solution in equal proportions and pour them into petri dishes, 10ml per dish. After the agar has solidified, put one piece of negative control and one piece of positive control in each plate, and 2 pieces of test samples. After incubating at 37°C for 24 hours, the samples were discarded, stai...

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PUM

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Abstract

The invention relates to a medicinal carrier for administration of a skin wound, and a preparation method and application thereof. The invention discloses an acrylate acetylglucosamine compound and a polymer thereof. The acrylate acetylglucosamine compound and the polymer thereof have the structure which is shown as the general formula described in the specification. The compounds have very good biocompatibility, have no toxic or side effect on cells, can be biodegraded, and can be used for repair and administration of skin damage and an ulcer surface.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to an acrylate acetylglucosamine compound with skin repairing and drug loading functions, a preparation method and application thereof. Background technique [0002] 1. diabetic ulcer [0003] Diabetic refractory ulcer is one of the common complications of diabetes caused by diabetic microangiopathy and neuropathy. Autologous skin transplantation has achieved great success in the treatment of diabetic skin ulcer, but the new surgical trauma and insufficient source of autologous skin Limiting its clinical application, with the development of tissue engineering technology, the development of tissue engineered skin for the treatment of diabetic skin ulcers has become the focus of attention. [0004] 2. Full-thickness skin damage caused by burns [0005] Full-thickness skin defect caused by severe trauma, extensive burns and other reasons is one of the common clinical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H13/04C07H1/00C08F122/22A61K9/06A61K47/32A61P17/02A61L26/00
CPCA61K9/06A61K47/32A61L26/0014A61L26/009C07H1/00C07H13/04C08F122/1006C08L35/02
Inventor 王晓辉高萍陈斌郑夺汤平平陶遵威
Owner 天津市医药科学研究所