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Use of alhagi sparsifolia shap. petal ethyl acetate parts

A technology of ethyl acetate and camel thorn, which is applied in the field of anti-diabetic drugs and health care products, and can solve problems such as ineffective insulin and decreased sensitivity of insulin receptors

Inactive Publication Date: 2016-08-10
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the sensitivity of the insulin receptor is reduced, so the insulin in the patient's body does not work

Method used

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  • Use of alhagi sparsifolia shap. petal ethyl acetate parts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The camel thorn petals are soaked at room temperature for 3 days with a concentration of 50% ethanol at a weight-to-volume ratio of camel thorn petals:ethanol=1:10 to obtain an alcohol extract;

[0018] Distill the ethanol extract under reduced pressure to remove ethanol to obtain a concentrated solution, then disperse the concentrated solution with water, then extract with ethyl acetate, steam the extract under reduced pressure to syrupy state, and dry it at 40°C to obtain camel thorn Ethyl acetate parts of petals.

Embodiment 2

[0020] The camel thorn petals are extracted with a concentration of 50% ethanol in a weight-to-volume ratio of camel thorn petals:ethanol=1:10, and the temperature is 85° C. under reflux to obtain an alcohol extract;

[0021] Distill the ethanol extract under reduced pressure to remove ethanol to obtain a concentrated solution, disperse the concentrated solution with 5% ethanol, and then extract with ethyl acetate, distill the extract under reduced pressure to syrupy state at a temperature of 42°C Dry to obtain the camel thorn petal ethyl acetate part.

Embodiment 3

[0023] The camel thorn petals are extracted with a concentration of 70% ethanol in a weight-to-volume ratio of camel thorn petals:ethanol=1:10, and the temperature is 60° C. under reflux to obtain an alcohol extract;

[0024] Distill the ethanol extract under reduced pressure to remove the ethanol to obtain a concentrated solution, disperse the concentrated solution with 10% ethanol, and then extract with ethyl acetate, evaporate the extract to syrup under reduced pressure, and the temperature is 43°C Dry to obtain the camel thorn petal ethyl acetate part.

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Abstract

The invention relates to use of alhagi sparsifolia shap. petal ethyl acetate parts. The ethyl acetate parts are extracted and leached from popular uygur medicinal materials alhagi sparsifolia shap. petals by adopting a conventional method, and the effects of PTP1B inhibitors of the ethyl acetate parts and use of anti-diabetes drugs and healthcare products formed by the ethyl acetate parts are proven by in-vitro experiments.

Description

technical field [0001] The invention relates to the use of the ethyl acetate part of camel thorn petals as an antidiabetic drug and a health care product as a protein tyrosine phosphatase 1B inhibitor. It has the effect of protein tyrosine phosphatase 1B (PTP1B) inhibitor confirmed by in vitro experiments. Background technique [0002] Camel thorn (Alhagi sparsifolia Shap.) is mainly distributed in North Africa, the Mediterranean Sea, West Asia, Kazakhstan, Uzbekistan, Turkmenistan, Kyrgyzstan, Tajikistan and Ukraine, and the main domestic production area is Xinjiang. Camel thorn is a perennial herb or semi-shrub plant, with cylindrical stems, many branches, slightly curved branches, up to 1m long, 0.2-0.7cm in diameter; slightly hard, with pith in the middle of the section. Branches and leaf axils have needles, up to 5cm long; single leaves grow on each other, oval or oval in shape, petiole 0.3-1cm long; most of the leaves have fallen off or shrunk, broken, and the intact ...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P3/10A23L33/105A61K133/00
CPCA61K36/48A23V2002/00A61K2236/333A61K2236/55A23V2200/328A23V2250/21
Inventor 阿吉艾克拜尔·艾萨郭丹邹国安信学雷
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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