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Use of Klotho gene editing in hetero-kidney transplatation

A gene editing and gene technology, applied in the fields of application, genetic engineering, plant gene improvement, etc., can solve the problems of short survival time, chronic failure of transplanted kidneys, etc., and achieve the effect of prolonging the survival time

Active Publication Date: 2016-08-10
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to short survival time, kidney transplantation is prone to chronic kidney failure caused by chronic kidney disease

Method used

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  • Use of Klotho gene editing in hetero-kidney transplatation
  • Use of Klotho gene editing in hetero-kidney transplatation
  • Use of Klotho gene editing in hetero-kidney transplatation

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Embodiment Construction

[0025] The present invention will be further described in detail below through specific embodiments in conjunction with the accompanying drawings.

[0026] Klotho (Genbank ID: 9365 (human) and ID: 100519728 (pig)) gene was originally discovered as a gene related to anti-aging, and the disordered expression of klotho gene can lead to shortened life span, hyperphosphatemia, atherosclerosis A series of phenotypes such as osteoporosis and osteoporosis, which are highly similar to the clinical manifestations of chronic kidney disease (CKD). In the early stage of CKD, the content of klotho protein in the serum of patients showed a downward trend, which can be used as one of the earlier biological markers, and the decline of klotho protein content became more and more obvious with the development of CKD.

[0027] Klotho gene is mainly expressed in the kidney, and its products include membrane-bound and secreted proteins, which serve as membrane-bound receptors and humoral regulators,...

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Abstract

The invention discloses a use of Klotho gene editing in hetero-kidney transplantation. Through Klotho gene editing, acute and chronic damage to a hetero-kidney is prevented, hetero-kidney normal state and functions are kept and survival time of the hetero-kidney in a receptor is prolonged.

Description

technical field [0001] This application relates to the field of xenogeneic organ transplantation, and relates to the anti-aging gene editing of xenogeneic organ donors. Background technique [0002] Organ transplantation is the most effective treatment for end-stage organ failure diseases, but the shortage of donor organs seriously restricts the development of organ transplantation. The shortage of donor organs in my country is extremely serious. There are as many as 1 million kidney transplant patients every year, and the number of kidney transplant operations that can be carried out in the country does not exceed 10,000. Therefore, allogeneic organs are far from meeting the needs of organ transplantation. It is urgent to find new sources of donor organs. [0003] Xenotransplantation is the transplantation of organs, tissues and cells from other species into humans. The abundant sources of xenogeneic organs are expected to become one of the fundamental ways to solve the sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/071C12N15/12
CPCC07K14/47C12N5/069C12N2501/998C12N2510/00
Inventor 牟丽莎刘璐蔡志明
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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