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Method for building fingerprint spectrum for radix paeoniae alba pharmaceutic preparation

A technology of pharmaceutical preparations and fingerprints, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of time-consuming joint detection of multiple detection indicators, detection and quality control of detection indicators, single white peony formula granules, etc., to improve safety Sex and stability, high precision, high stability effect

Inactive Publication Date: 2016-08-17
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, what the present invention is to solve is that the single detection index of the existing detection method of Radix Paeoniae Alba formula granules cannot detect and control its quality as a whole, and the combined detection of multiple detection indexes is time-consuming and laborious, and is difficult to be widely used in production practice. technical problems, thereby proposing a method for establishing the fingerprint of the medicinal preparation of Radix Paeoniae Alba

Method used

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  • Method for building fingerprint spectrum for radix paeoniae alba pharmaceutic preparation
  • Method for building fingerprint spectrum for radix paeoniae alba pharmaceutic preparation
  • Method for building fingerprint spectrum for radix paeoniae alba pharmaceutic preparation

Examples

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Effect test

Embodiment 1

[0055] In the following examples and experimental examples, the preparation method of Radix Paeoniae Alba Formula Granules is:

[0056] Take Radix Paeoniae Alba, heat and reflux to extract twice, add 8 times the weight of water for the first time to extract for 1.5 hours, add 6 times the weight of water for the second time, extract for 1 hour, filter, combine the filtrates, and concentrate the filtrates to a relative density of 60°C The liquid extract is 1.05-1.10, adding conventional auxiliary materials, and making granules according to the conventional process. ,

Embodiment 2

[0058] The present embodiment establishes the method for the fingerprint of Radix Paeoniae Alba formula granule, comprises the following steps:

[0059] (1) Take 0.10g of white peony formula granules to be tested, accurately weighed, accurately add 20mL of dilute ethanol, weighed, heat reflux extraction or ultrasonic extraction for 30 minutes, let cool, weigh again, take dilute ethanol to make up for the lost Shake up, filter, get continued filtrate, as need testing solution;

[0060] (2) Accurately weigh the reference substance of paeoniflorin, add methanol to make a solution containing 0.00006g per 1mL, shake well, and use it as the reference substance A solution;

[0061] Precisely weigh paeonifloride reference substance, add methanol to make a solution containing 0.0010g per 1mL, shake well, and use it as reference substance B solution;

[0062] Precisely weigh hydroxypaeoniflorin reference substance, add methanol to make a solution containing 0.00013g per 1 volume part, ...

Embodiment 3

[0067] The present embodiment establishes the method for the fingerprint of Radix Paeoniae Alba formula granule, comprises the following steps:

[0068] (1) Take 0.05g of Radix Paeoniae Alba Formula Granules to be tested, accurately weighed, accurately add 30mL of dilute ethanol, weighed, heat reflux extraction or ultrasonic extraction for 20 minutes, let cool, weigh again, take dilute ethanol to make up for the lost Shake up, filter, get continued filtrate, as need testing solution;

[0069] (2) Accurately weigh the reference substance of paeoniflorin, add methanol to make a solution containing 0.00010g per 1mL, shake well, and use it as the reference substance A solution;

[0070] Accurately weigh paeonifloride reference substance, add methanol to make a solution containing 0.0015g per 1mL, shake well, and use it as reference substance B solution;

[0071] Precisely weigh hydroxypaeoniflorin reference substance, add methanol to make a solution containing 0.00014g per 1 volu...

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Abstract

The invention relates to a method for building a fingerprint spectrum for a radix paeoniae alba pharmaceutic preparation. The method comprises the steps that radix paeoniae alba formula granules are adopted as a detection object, the fingerprint spectrum for the radix paeoniae alba pharmaceutic preparation is built, comprehensive spectrum information is obtained, first peak hydroxy-paeoniflorin, second peak albiflorin std and third peak paeoniflorin sharing the characteristic peaks are determined, the third peak paeoniflorin is selected as an internal reference peak in the fingerprint spectrum, and the relative retention time of the first, second, fourth and other shared characteristic peaks of the radix paeoniae alba formula granules is determined; on the basis of the information of the multiple chromatographic peaks in the fingerprint spectrum, the quality of the radix paeoniae alba formula granules can be comprehensively and rapidly detected, comprehensive quality detection and overall quality control are promoted, and therefore the medicine using safety and stability are improved. Meanwhile, the method for building the fingerprint spectrum for the radix paeoniae alba pharmaceutic preparation has the advantages of being high in stability and precision, good in repeatability and the like.

Description

technical field [0001] The invention belongs to the field of drug analysis, and in particular relates to a method for establishing a fingerprint of a medicinal preparation of Radix Paeoniae Alba. Background technique [0002] Paeoniae Alba Formula Granules are obtained by extracting, concentrating and granulating the decoction pieces of Radix Paeoniae Alba. Radix Paeoniae Alba is the dry root of Paeonia lactiflora Pall., a plant of the family Ranunculaceae, which mainly contains monoterpene glycosides such as paeoniflorin, paeoniflorin, and hydroxypaeoniflorin, and acid components such as benzoic acid and gallic acid; Excavated, washed, removed the head and tail and heels, boiled in boiling water, removed the skin or peeled and then boiled, dried, mainly produced in Zhejiang, Anhui, Sichuan and other places, in addition, Shandong, Guizhou, Hunan, Hubei, It is also produced in Gansu, Shaanxi, Henan, Yunnan and other places. Paeoniae Alba is bitter in nature and flavor, retu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 谭沛张辉郑晓英马鹏岗严萍张洁詹若挺陈蔚文林文华
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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