Plant protein empty capsule and preparation method thereof

A hollow capsule and vegetable protein technology, which is applied in capsule delivery, medical preparations of non-active ingredients, and pharmaceutical formulas, etc. It can solve the problems of sensitivity to changes in temperature and humidity of gelatin capsules, potential safety hazards of animal protein, inconvenient transportation and storage, etc. , to achieve the effect of unbreakable, good product performance, convenient transportation and storage

Inactive Publication Date: 2016-08-24
西宁鑫沃化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The raw material of traditional medical hollow capsules is medicinal gelatin, which belongs to animal protein, but animal protein has potential safety hazards; in addition, gelatin capsules are sens

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The present invention is a vegetable protein hollow capsule whose raw materials are composed of: hydroxypropyl methylcellulose (HPMC): 73.7%, pharmaceutical grade polyvinylpyrrolidone (PVP): 8%, pharmaceutical grade 1788 polymer Vinyl alcohol (PVA): 1%, glycerin: 2.5%, polyethylene glycol (PEG): 2.5%, titanium dioxide: 3%, water-soluble colorant: 0.3%, gellan gum: 6%, calcium chloride: 2 %, surfactant is sodium lauryl sulfate (K12): 1%. Mix it and add it to water to prepare a glue solution with a concentration of 30% and a viscosity of 1000-10000 centipoise. After controlling the temperature of the glue solution at 32°C, let it stand in the glue tank or decompress it until it is completely degassed. , Preheat the pintle to 80°C before dipping it in the glue, then immerse the pintle into the glue solution with a temperature of 32°C, let it stand for 2 minutes and then take it out, and put the pintle out in a closed drying box with a temperature of 45-60°C Baking in the ...

Embodiment 2

[0016] The present invention is a vegetable protein hollow capsule. The raw materials are composed of: pullulan: 77.4%, chitin (chitosan): 6%, pharmaceutical grade 1788 polyvinyl alcohol (PVA): 2%, Glycerin: 2%, polyethylene glycol (PVP): 2.5%, barium sulfate: 2%, water-soluble colorant: 0.3%, pectin: 5%, potassium chloride: 2%, surfactant is dodecane Sodium base sulfate (K12): 0.8%. Mix it and add it to water to prepare a glue solution with a concentration of 30% and a viscosity of 1000-10000 centipoise. After controlling the temperature of the glue solution at 32°C, let it stand in the glue tank or decompress it until it is completely degassed. Preheat the temperature to 80°C before dipping the needle in the glue, then immerse the needle needle in the glue solution at 32°C, let it stand for 2 minutes, take out the needle needle, and bake it in a closed drying oven at a temperature of 45-60°C for 2 minutes. A layer of hard-shell-like blended polymer film is formed, and the p...

Embodiment 3

[0018] The raw material of the hollow capsule of a kind of vegetable protein of the present invention is composed by mass percentage: Hydroxypropyl cellulose (HPC): 75.8%, pharmaceutical grade polyvinylpyrrolidone (PVP): 3%, pharmaceutical grade 0588 polyvinyl alcohol (PVA): 3%, mannitol: 3%, polyethylene glycol (PEG): 3%, precipitated calcium carbonate: 2%, water-soluble color: 0.2%, carrageenan: 6%, potassium citrate: 3%, surfactant lauryl sulfate (K12): 1%. Mix it and add it to water to prepare a glue solution with a concentration of 30% and a viscosity of 1000-10000 centipoise. After controlling the temperature of the glue solution at 32°C, let it stand in the glue tank or decompress it until it is completely degassed. Preheat the needle to 80°C before dipping it in glue, then immerse the needle in the glue solution at 32°C, let it stand for 3 minutes, then take it out, and bake the taken out needle in a closed drying oven at a temperature of 45-60°C for 2 minutes. A laye...

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PUM

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Abstract

The invention relates to a plant protein empty capsule and a preparation method thereof. The plant protein empty capsule is prepared from the following raw materials in percentage by mass: 73.7% of hydroxypropyl methyl cellulose (HPMC), 8% of pharmaceutical-grade polyvinylpyrrolidone (PVP), 1% of pharmaceutical-grade 1788 polyvinyl alcohol (PVA), 2.5% of glycerol, 2.5% of polyethylene glycol (PEG), 3% of titanium dioxide, 0.3% of water soluble pigment, 6% of gellan gum, 2% of calcium chloride and 1% of a surfactant which is lauryl sodium sulfate. The preparation method of the plant protein empty capsule comprises the following steps: forming a layer of hard shell blending polymer on an axial needle, demoulding and trimming to prepare a capsule shell.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, in particular to a vegetable protein hollow capsule and a preparation method thereof. Background technique [0002] The raw material of traditional medical hollow capsules is medicinal gelatin, which belongs to animal protein, but animal protein has potential safety hazards; in addition, gelatin capsules are sensitive to changes in temperature and humidity. If the temperature and humidity are not properly controlled, they are easy to break and are inconvenient Transportation and storage, and high production costs. Contents of the invention [0003] In order to solve the above-mentioned problems in the prior art, the present invention provides a vegetable protein hollow capsule and a preparation method thereof. [0004] The technical solution of the present invention is: a hollow capsule of vegetable protein, characterized in that, the raw material of the hollow capsule of vegetable ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/32A61K47/36A61K47/44
CPCA61K9/4825A61K47/32A61K47/36A61K47/44
Inventor 刘杰
Owner 西宁鑫沃化工有限公司
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