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Preparation method of liver-smoothing injection preparation

An injection preparation and liver-soothing technology, which is applied in the field of preparation of Shuganning injection preparations, can solve the problems of low indigo content, affecting the efficacy of drugs, and difficult detection of indigo in Radix isatidis, and achieve the goal of improving drug efficacy and high indigo content Effect

Inactive Publication Date: 2016-09-07
GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The inventor has conducted a lot of research on the raw materials used to make Shuganning injection, the Radix Radix Radix and the Extract of Capillaris and their extraction process. During the research, the inventor found that using the existing Extract of Radix In the prepared Shuganning injection, the indigo in Radix isatidis is difficult to detect
The indigo in Radix isatidis is the main active ingredient of Radix isatidis, but the content of indigo in the Shuganning preparation made from the extract of Radix isatidis prepared by the prior art and the extract of capillary wormwood is not high, which affects the curative effect of the medicine

Method used

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  • Preparation method of liver-smoothing injection preparation
  • Preparation method of liver-smoothing injection preparation
  • Preparation method of liver-smoothing injection preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Recipe: 4g capillary extract, 3g gardenia extract, 22g baicalin, 5g isatidis extract and 3.5g ganoderma extract.

[0073] The preparation method of Shuganning injection: add water for injection to baicalin, make it suspended, and then add 10% sodium hydroxide solution to dissolve it; Add water for injection to dissolve, mix well, add 0.2% activated carbon, stir well, boil for 15 minutes, filter, adjust pH value to 7.5-8.0 with 10% sodium hydroxide solution, add water for injection to 1000ml, filter, potting , sterilized to obtain the injection.

[0074] Extraction process of capillary extract: take capillary, add 6 times the amount of soaking solution to soak for 8-12 hours, filter, add 10 times the amount of 80% ethanol to heat and reflux extraction for 3 times, each time for 2 hours, filter, and dregs For standby, the extract is decompressed to recover ethanol, add water to the concentrated solution until the ratio of volume per milliliter to medicinal material per g...

Embodiment 2

[0082] Recipe: 4g capillary extract, 3g gardenia extract, 22g baicalin, 5g isatidis extract and 3.5g ganoderma extract.

[0083] The preparation method of Shuganning injection: add water for injection to baicalin, make it suspended, and then add 10% sodium hydroxide solution to dissolve it; Add water for injection to dissolve, mix well, add 0.2% activated carbon, stir well, boil for 15 minutes, filter, adjust pH value to 7.5-8.0 with 10% sodium hydroxide solution, add water for injection to 1000ml, filter, potting , sterilized to obtain the injection.

[0084] The extraction process of capillary extract: take capillary, add 7 times the amount of soaking solution to soak for 12 hours, filter, add 12 times the amount of 85% ethanol to heat and reflux extraction for 5 times, each time for 3 hours, filter, and the dregs for later use. Recover ethanol from the extract under reduced pressure, add water to the concentrated solution until the ratio of volume per milliliter to medicin...

Embodiment 3

[0089] Recipe: 4g capillary extract, 3g gardenia extract, 22g baicalin, 5g isatidis extract and 3.5g ganoderma extract.

[0090] The preparation method of Shuganning injection: add water for injection to baicalin, make it suspended, and then add 10% sodium hydroxide solution to dissolve it; Add water for injection to dissolve, mix well, add 0.2% activated carbon, stir well, boil for 15 minutes, filter, adjust pH value to 7.5-8.0 with 10% sodium hydroxide solution, add water for injection to 1000ml, filter, potting , sterilized to obtain the injection.

[0091] Extraction process of capillary extract: take capillary, add 5 times the amount of soaking solution to soak for 8 hours, filter, add 8 times the amount of 70% ethanol to heat and reflux for extraction for 3 hours, filter, use the dregs for later use, and recover the extract under reduced pressure Ethanol, add water to the concentrated solution until the ratio of volume per milliliter to medicinal material per gram is 1:...

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Abstract

The invention discloses a preparation method of a liver-soothing injection preparation. The liver-soothing injection preparation is mainly prepared from a herba artemisiae scopariae extract, a fructus gardeniae extract, baicalin, a radix isatidis extract and a ganoderma extract; by means of the preparation method of the liver-soothing injection preparation, the specific process and parameters are improved, the effective component indigo in radix isatidis can be detected easily, and the content of detected indigo is high. The drug efficacy of the liver-soothing injection preparation can be effectively improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation method of Shuganning injection preparation. Background technique [0002] Extraction of traditional Chinese medicine is a commonly used method in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex, and it is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture. to improve efficacy. [0003] Shuganning injection is a liver-protecting drug, mainly made of capillary extract, gardenia extract, baicalin, isatis root extract and ganoderma lucidum extract. It has the effects of clearing away heat and detoxification, promoting dampness and reducing jaundice, nourishing qi and strengthening the body, and protecting the liver. It is used for damp-heat jaundice, yellow eyes and eyes, fullness of breast ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/08A61P1/16A61K31/7048
CPCA61K36/282A61K9/0019A61K9/08A61K31/7048A61K36/074A61K36/195A61K36/315A61K36/744A61K2236/331A61K2236/333A61K2236/39A61K2236/55
Inventor 熊毅刚张丽姚光哲张昀
Owner GUIZHOU RUIHE PHARMA CO LTD LONGLI PHARMA FACTORY