A bioresponsive targeted dual-drug sustained-release carrier material and preparation method thereof

A slow-release carrier and responsive target technology, which can be used in pharmaceutical formulations, drug delivery, medical preparations with inactive ingredients, etc. The effect of good biological responsiveness
CN105943520BInactive Publication Date: 2019-03-19WUHAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN UNIV OF TECH
Publication Date
2019-03-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of targeted drug slow-release carrier materials, and particularly relates to a biological responsiveness targeted double-drug slow-release carrier material and a preparation method thereof. The biological responsiveness targeted double-drug slow-release carrier material is prepared from double-shell biological responsiveness nanometer microspheres; an inner shell of the material is prepared from nanometer microspheres formed by aggregating amphiphilic polymers; an outer shell of the material is mesoporous silica; the diameter of the inner shell is 160nm to 800nm; the mesoporous diameter of the mesoporous silica of the outer shell is 2 to 4nm. The amphiphilic polymer nanometer microspheres of the inner shell can provide load loci for a hydrophobic drug, and the mesoporous silica of the outer shell can provide load loci for a hydrophilic drug; hence, the biological responsiveness targeted double-drug slow-release carrier material can load two different drugs and realize slow release of the double drugs, so as to achieve the aim of double-drug synergy therapy.
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Description

technical field

[0001] The invention belongs to the field of targeted drug slow-release carrier materials, in particular to a bioresponsive targeted double-drug slow-release carrier material and a preparation method thereof. Background technique

[0002] As the degree of social industrialization increases and environmental pollution becomes more and more serious, the human cancer rate increases year by year. At the same time, with the progress of social civilization, people pay more and more attention to their own quality of life and physical health. Therefore, the treatment of cancer has become an urgent problem for scientists and medical scientists since the 20th century. The current drugs for treating cancer are mainly composed of some hydrophobic organic molecules containing a large number of benzene rings or pyridine groups. However, human blood is a hydrophilic environment, and drugs are difficult to dissolve in blood, which poses a major challenge to the transportat...

Claims

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