147results about How to "Produce toxic side effects" patented technology

The invention relates to a feed capable of improving selenium content in chicken meat and egg and a preparation method thereof. The invention is characterized in that: the feed is prepared from selenium-enriched food grains, bean pulp, calcium hydrophosphate, salt, worms, pine needle meal, garlic powder and origano oil powder serving as raw materials; and the preparation method comprises the following steps of: mixing the bean pulp and the peanut meal, and adding water for stirring; performing fermentation twice, taking the mixture out and crushing into granules; mixing with other raw materials, adding into a feed stirrer, continuously and uniformly stirring, and putting into a crusher for preliminary crushing; taking the crushed materials out and putting into an ultra-micro crusher for secondary crushing to form fine granules; and sterilizing, sealing and packaging the crushed fine granules to prepare the finished feed. The selenium content in the chicken meat can be improved by about three times after chickens eat the feed, the selenium content in the egg can be improved by over ten times, and the selenium content can meet human demands and accords with national standard.

The present invention discloses a Chinese medicine foot-soaking powder for external application. It is made up by using 15 Chinese medicinal materials of clematis root, star jasmine stem, chaenomeles fruit, dried ginger, aconite accessory tuber, cinnamon twig and others as raw material, pulverizing them to obtain the invented medicine powder. When it is used, the medicine power is added into hot water to soak foot. It has the effect for curing general diseases and building up body.

The invention discloses a bioabsorbable compound stent. An ultra-fine grain magnesium alloy stent is used as a matrix, a completely degradable polymer material is coated on the surface of the ultra-fine grain magnesium alloy stent as an anticorrosion and mechanical-support protective layer, and a medicinal carrier coating is applied outside the protective layer. The magnesium alloy material is a three-component alloy or multi-component alloy composed of one or the combination of the following alloy systems: Mg-Fe, Mg-Mn, Mg-Zn, Mg-Ca, Mg-Y and Mg-RE. The stent can provide sufficient mechanical support for blood vessels and effectively avoid resilience. The stent can effectively reduce the overhigh corrosion rate of the magnesium alloy after being implanted into the human body, and ensure that the blood vessels can gain sufficient mechanical support in the early endothelialization period, so that the service time of the stent and the blood vessel endothelialization time are optimally matched, and the stent can be completely degraded within an appropriate time.

The invention relates to the field of grape wine, in particular to grape wine added with procyanidin B2 and a preparation method. The invention is characterized in that the addition quantity of a grape pip extract in the wine is 0.01-20mg/mL, the content of the procyanidin B2 in the extract is 20-98%, the addition quantity of the procyanidin B2 in the wine is ensured to reach 0.002-19.6mg/mL, the addition quantity of sucrose in the wine is 20-200mg/mL, and the addition quantity of zymosan in the wine is 0.2-0.3mg/mL. After the husks of grape raw materials are broken, the peduncles of the grape raw materials are removed and the grape raw materials are pulped, the grape pip extract, the sucrose and the zymosan are added into the grape pulp according to the above addition quantity, and the grape wine is prepared by fermentation, deposit, filtration, filling and aging. The invention enhances the content of the procyanidin B2 in the grape wine, reinforces the health-care function of the grape wine, improves the production technique procedures simultaneously and improves a product in various aspects of the appearance, the colour, the fragrance, the mouth feel, the aftertaste and the like.

The invention relates to a veterinary medicament, in particular to a medicament which consists of natural plants and natural mineral compositions, and particularly relates to a veterinary medicament for preventing and treating colibacillosis and/or white diarrhea, in particular to a medicament for treating the colibacillosis and/or the white diarrhea of poultry. The medicament consists of the following compositions: honeysuckle, gypsum, radix paeoniae rubra, Chinese pulsatilla, weeping forsythia, cyrtomium rhizome, kuh-seng, Chinese ephedra, Astragalus membranaceus, isatis root, and liquorice.

The invention relates to the technical field of medicinal chemistry, particularly discloses a small-molecule inhibitor of Mdm<X>/Mdm<2>, and also relates to a preparation method of the small-molecule inhibitor of Mdm<X>/Mdm<2>. The small-molecule inhibitor compound can inhibit the interaction of Mdm<X> protein and p53 protein and also can inhibit the interaction of Mdm<2> protein and p53 protein, has antiproliferative activity on cancer cells, and cannot generate toxic and side effects on patients. The small-molecule inhibitor compound can be combined with other therapies for use.

The invention discloses a traditional Chinese medicine used for treating bone injury, postoperative bone nonunion and delayed union and a preparation method thereof. The invention consists of twenty six traditional Chinese medicines of frankincense, hemlock parsley, cassia twig, myrrh, angelica, rhizoma corydalis, safflower, fossil bone, rhizoma drynariae, elecampane, eucommia bark, dipsacus asperoides, Chinese goldthread, mirabilite, ground beetle, earthworm, DiFeng, Chinese fresh-water crab, oyster, rhubarb, pseudoginseng, borneol, pearl, muskiness, dragon's blood and tiger bone. The invention has good curative effect for the patients with bone injury and fracture nonunion.

The invention relates to a cross-linking modification method of antibacterial gelatin. The method comprises the following steps: 1, a natural biological material is used as a cross-linking agent to besubjected to a cross-linking reaction with antibacterial gelatin, wherein the pH of a solution in the cross-linking reaction is 9-11, the concentration of the cross-linking agent is 0.5-0.8 wt%, themass ratio of the cross-linking agent to the antibacterial gelatin is (0.03-0.08):1, the temperature of the cross-linking reaction is 42-58 DEG C, and the time of the cross-linking reaction is 2-10 h.The natural biological cross-linking agent is selected for cross-linking modification and the mechanical property of the antibacterial gelatin is improved; meanwhile, no toxic or side effect is generated on the human body, and the use safety of the gelatin material is improved. In addition, crosslinking modification conditions are optimized, so that the crosslinked gelatin with good biocompatibility and excellent mechanical properties is obtained, and the application of the crosslinked gelatin in medical antibacterial materials is facilitated.

The invention discloses a Chinese medicament formula for treating allergic rhinitis. The Chinese medicament formula is characterized by comprising the following ingredients by weight: 10 grams of baikal skullcap root, 10 grams of cassia twig, 5 grams of ephedra herb, 6 grams of angelica root, 15 grams of biond magnolia flower, 15 grams of double blossom, 10 grams of mongolian dandelion herb, 10 grams of bunge corydalis herb, 10 grams of divaricate saposhnikovia root, 8 grams of cicada slough, and 5 grams of borneol. The ingredients in the Chinese medicament formula are natural herbal ingredients which do not contain hormones, do not have sensitization and dependency, and are safe and reliable, so that the Chinese medicament formula cannot cause any toxic or side effect on human bodies, is simple and convenient, easy to take and low in cost, causes small pains to patients, and more importantly is quick in response for treating the allergic rhinitis and has a high curative ratio.

Belonging to the field of medical materials, the invention in particular relates to a super-paramagnetic targeting dual-drug sustained-release carrier material and a preparation method thereof. The inner shell of the carrier material is super-paramagnetic Fe3O4 hollow microspheres, and the outer shell is mesoporous silica, the inner shell is accumulated by Fe3O4 nanoparticles and has a thickness of 5-50nm, and the accumulation holes formed between the Fe3O4 nanoparticles are mesopores. The outer shell is formed by hydrolysis of a silicon source, and the mesoporous aperture of the mesoporous silica is 2-4nm. The super-paramagnetic Fe3O4 hollow microspheres of the inner shell involved in the invention can load hydrophobic drug, and the outer shell mesoporous silica can load hydrophilic drugs, and the drugs are released through the mesopores of the inner shell and the outer shell. Therefore, the super-paramagnetic targeting dual-drug sustained-release carrier material provided by the invention can load two different drugs, and under the orientation action of a magnetic field, can realize targeted sustained-release of dual drugs so as to achieve the purpose of synergy therapy of dual drugs.

The invention discloses a fully-degradable and anti-tumor macromolecular drug with a multi-drug synergistic effect and a preparation method of the fully-degradable and anti-tumor macromolecular drug.The anti-tumor macromolecular bonded drug takes polylactide as a main chain, a hydrophilic branch chain of polyethylene glycol is introduced, and various anti-tumor drugs are grafted. The preparationmethod of the anti-tumor drug comprises the steps as follows: firstly, polylactide containing norbornene side groups is prepared, methoxypolyethylene glycol branch chains are introduced through an azide-ene click reaction sequentially, azide side groups are modified by a photo-click reaction and an esterification reaction of thio-ene, and finally, anti-tumor drug molecules are introduced by a force actuated azide-alkyne cycloaddition reaction. According to the method, the anti-tumor macromolecule bonded drug is synthesized with various click reactions, and the method has the characteristics ofsimplicity, high efficiency, mild reaction conditions, large drug loading amount, high purity and the like; the anti-tumor macromolecular bonded drug has the advantages that the anti-cancer activityis improved through the synergistic action of multiple drugs, and the dosage of each drug can be reduced due to the combined action of the multiple drugs, and accordingly, toxic and side effects of chemotherapy are reduced.

The invention relates to a pure natural piglet immunological enhancement feed additive and application thereof. The feed additive is characterized by comprising the following raw material components in percentage by weight: 15 to 18 percent of Chinese pulsatilla root, 15 to 18 percent of ash bark, 9 to 12 percent of talc, 12 to 15 percent of wrinkled gianthyssop herb, 5 to 7 percent of hawthorn fruit, and 35 to 38 percent of pine needle meal. The feed additive is added into a piglet complete feed with the addition of 0.05 to 0.1 g/kg. The pure natural piglet immunological enhancement feed additive has the advantages that: the dosage is small, only 0.05 to 0.1 gram of the feed additive is added into one kilogram of the feed, so the feed additive generates no toxic or side effects on an animal and simultaneously cannot increase the production cost; the dosage of the feed additive is determined based on a medicament property theory of Chinese herbal medicaments, a relation between medicaments and physiological characteristics of piglets, and the medicaments are mixed reasonably; besides, the medicament formula consists of common Chinese herbal medicaments. The feed additive can effectively improve the piglet immunity and reduce the diarrhea rate so as to improve the feed intake and promote the growth; besides, the feed additive is nontoxic and provides a new way for producing safe and green pork.

The invention relates to the field of foods, in particular to an alginate oligomer dairy capable of reducing cholesterol. The dairy disclosed by the invention contains alginate oligomers of which the mass percentage is 1-10%, and the molecular weight scope of the alginate oligomers is 2000-3000Da. The level of serum cholesterol can be obviously reduced by restraining the absorption of cholesterol by small intestines. After the alginate oligomers are prepared into the diary disclosed by the invention, the alginate oligomers are easier to absorb, and the diary has better effects of reducing the content of the cholesterol and the content of triglyceride in blood than a general dairy and initial alginate oligomer powder. Besides, the alginate oligomers interact with orotic acid in the dairy to restrain a reaction of synthesizing the cholesterol by livers and restrain the absorption of cholesterol by small intestines, so that the content of the cholesterol and the content of the triglyceride in the blood can be obviously reduced by the alginate oligomer dairy.

The invention discloses a preparation method for a micro-arc oxidation-dopamine coupling carried traditional Chinese medicine coating of a pure titanium oral implant and relates to a preparation method for a pure titanium oral implant. The preparation method disclosed by the invention aims to solve the technical problem of implantation failure as an existing titanium oral implant is slowly healed in the early implanting period and bacteria invade after implantation to lead to early infection after an implant surgery. The preparation method provided by the invention comprises the steps of: I, pre-treatment of the surface of a pure titanium test sample; II, preparation of a micro-arc oxidation electrolyte; III, ultrasonic micro-arc oxidation treatment; and IV, post-treatment. After micro-arc oxidation on the surface of a pure titanium implanting material, the material is modified by taking dopamine as a coupling agent carrying traditional Chinese medicines, so that growth and development of skeleton are promoted, material metabolism of human cells is enhanced, aging of muscles and skeleton is prevented, and the broad-spectrum antibacterial action is improved, and therefore, a novel bone implant which is better in biocompatibility and faster to heal is obtained.

The invention relates to an effervescent traditional Chinese medicine composition having intestine-astringing and dysentery-relieving function and a preparation method thereof. The effervescent traditional Chinese medicine composition contains the following ingredients by weight percents: 5-20% of realgar; 5-20% of agastache; 5-20% of Chinese pulsatilla; 5-20% of talc; 5-20% of root and rhizome of delavay Meadowrue; 5-20% of myrobalam; 5-20% of purslane; 5-20% of radix scutellariae; 10-50% of effervescing agent and 1-20% of lubricating agent. The effervescent traditional Chinese medicine composition has the advantages of scientific and reasonable formulation, no toxic and side effect as well as residual medicine, simplified operation, saved cultivation cost, convenient use, fast effectiveness and high bioavailability, can effectively achieve sterilization and bacterial inhibition, and conforms to the standards of safe animal medicines.

The invention discloses a Eucalyptus polybractea essential oil with an anthelmintic effect, and a composite microbial agent and an application thereof. The Eucalyptus polybractea essential oil includes 1,8-cineole, beta-methylisopropylbenzene, limonene, alpha-pinene and alloaromadendrene, wherein the most important effective component of the Eucalyptus polybractea essential oil is 1,8-cineole. Theinvention also discloses the composite microbial agent prepared from the Eucalyptus polybractea essential oil and Streptomyces griseus HL-50 with the preservation number of CGMCC No.18424. The composite microbial agent can be applied to livestock and poultry breeding in order to effectively repel various parasites infecting livestock and poultry and inhibit bacteria. The essential oil has the advantages of natural components, excellent quality, and no influences on feeding and growth of animals, and the composite microbial agent also has the advantages of simplicity in preparation, safety inuse, no toxic or side effects, improvement of the growth performance and the intestinal health of livestock and poultry, reduction of the breeding cost, and wide application prospect.

The present invention discloses deodorizing bacteriostatic mildewproof powder preparation as one kind of externally applied disinfectant. The deodorizing bacteriostatic mildewproof powder preparation is prepared with nanometer zinc oxide powder 1-30 weight portions, maggot powder 5-75 weight portions and chitosan 5-65 weight portions, and through mixing. It has the functions of eliminating bad smell, inhibiting fungi and preventing mildew, and may be used in sterilizing article and environment as well as treating body odor and beriberi.

The present invention relates to an oral Chinese medicine preparation for curing nervous pain. Said Chinese medicine preparation is made up by using 8 Chinese medicinal materials of prepared aconite main tuber, prepared wild aconite tuber, Orient vine, chaenomeles fruit, Chinese angelica root, carthamus flower and others through a certain preparation process. Said Chinese medicine preparation can be used for effectively curing the diseases of nervous pain, sciatica, prosopalgia, lumbocrural pain and rheumatic arthralgia, etc. and can obtain obvious therapeutic effect.

The invention relates to a microbial fermented feed for preventing and treating constipation of sows and an application method thereof. Raw materials of the feed comprise (by weight): 28-31% of corn,25-27% of soybean meal, 4-6% of DDGS, 9-12% of corn gluten feed, 9-11% of corn germ meal, 17-19% of rice bran meal, 1.5-2.5% of stone flour, 0.3-1% of senna leaf, 0.1-0.3% of an aerobic starter, and 0.1-0.3% of an anaerobic starter. The feed product satisfies the types of nutrients essential for sows and carbon nitrogen ratio, pH, moisture, fermentable carbohydrates, osmotic pressure and the likewhich are essential for growth of microbes. In allusion to physiological characteristics of constipated sows, proper microbes are screened out for fermentation of the feed, and the feed has effects ofimproving raw materials of the feed and biological barrier of sows' intestinal tract, preventing and treating constipation of sows and raising reproductive performance of sows.

The invention relates to a preparation method and application of a Vibro harveyi and Vibrio parahaemolyticus bigeminy DNA vaccine. The Vibro harveyi and Vibrio parahaemolyticus bigeminy DNA vaccine is characterized by being a tdh2-oppA fusion gene protein eukaryotic expression engineering vector vaccine formed by connecting a Vibro harveyi oppA gene with a Vibrio parahaemolyticus tdh2 gene through 6 nucleotides GAATTC. The preparation method comprises the steps of: cloning the tdh2 gene and the oppA gene into a linear vector Pmd19-T Simple; inserting the fusion gene into a eukaryotic expression vector pEGFP-N1 by adopting a double-enzyme cleavage technology to construct a pEGFP-N1-tdh2-oppA fusion gene protein eukaryotic expression engineering vector vaccine; and finally preparing a Vibro harveyi and Vibrio parahaemolyticus bigeminy DNA vaccine suspension by using a conventional method, and immunizing fishes by the dosage of 100 microlitres per fish. The invention has strong operability, high repetition rate, safety, no toxic or side effect, double immune protection for fishes and higher immune effect than an inactivated vaccine, a recombinant protein vaccine and a common DNA vaccine.