Completely degradable polymer medicine elution stent and preparation method thereof

Abstract

The invention relates to a completely degradable polymer medicine elution stent and a preparation method thereof. The stent is prepared from the following steps: 1) processing and forming a degradable polymer material into a pipe; 2) subjecting the pipe to laser engraving to form a stent substrate; 3) polishing the surface of the degradable polymer stent substrate and removing processing defects on the surface of the stent; and 4) forming a medicine carrier coating on the surface of the degradable polymer stent substrate. In the invention, a novel light source is used for implementing the laser engraving of the pipe and the processing defects on the surface of the stent is polished by using a polishing technique, so the obtained stent has high structural stability and can has high mechanical supporting performance; and compared with the conventional method, the method has obvious advantages, the prepared stent has high biocompatibility, can effectively treat diseases such as intravascular stenosis and thrombus, has high positive remodeling effect on blood vessels and can effectively prevent a restenosis in later implanting period of the stent.

Description

technical field [0001] The invention relates to the field of material processing and implantable medical devices, in particular to a preparation method of a fully degradable polymer drug-eluting stent and related products. Background technique [0002] Since the world's first successful PCI operation in 1977, percutaneous coronary intervention has made great progress. The third milestone of interventional therapy for coronary heart disease, the first DES clinical trial results were announced at the Stockholm ESC Annual Conference in Sweden in 2001, proving that DES can significantly reduce in-stent restenosis. In 2002, the application of drug-eluting stents can effectively inhibit intimal hyperplasia and reduce vascular restenosis, and its clinical effect is encouraging. However, as time goes by, it is found that the long-term restenosis rate of DES has not been reduced as expected, especially the late thrombosis in the stent, which can reach 30%-40%. In 2006, there was ev...

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Problems solved by technology

[0004] Existing methods for preparing fully degradable drug-eluting stents mainly include: direct stent injection molding methods, weaving polymer filaments, thermosetting molding, etc., because these preparation methods all require high-precision molds, and due to The mold space is small, and the viscosity of the polymer is high, which is not conducive to the flow of the polymer, so it is easy to cause defects such as uneven scaffold structure and insufficient mechanical support performance

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