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Novel method for resisting breeding of lasiopodomys brandtii by adopting sophoricoside

An anti-fertility technology for Brucella voles, which is applied in the field of sophocaridin affecting the number of embryos implanted in Brucella voles to control their reproduction. It can solve the problems of environmental pollution, drug resistance, drug resistance, etc. wide range of effects

Inactive Publication Date: 2016-09-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemical rodenticides have a series of serious problems such as secondary poisoning, drug resistance, drug resistance, and environmental pollution, making traditional rodent control methods unable to meet the requirements of modern agriculture and animal husbandry development.

Method used

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  • Novel method for resisting breeding of lasiopodomys brandtii by adopting sophoricoside
  • Novel method for resisting breeding of lasiopodomys brandtii by adopting sophoricoside
  • Novel method for resisting breeding of lasiopodomys brandtii by adopting sophoricoside

Examples

Experimental program
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Effect test

example 1

[0035] Sophorin with a purity of 98% was selected as the infertility drug, and the female Brandt's vole mice on the first day of conception were used as the research object, and the dose of 450mg / kg / day was continuously administered by intragastric administration for 7 days, and the embryos were found to be implanted. The average number of beds was significantly reduced compared to the control group.

example 2

[0037] Sophorin with a purity of 98% was selected as the infertility drug, and the female Brandt's vole on the first day of conception was used as the research object, and the dose of 900mg / kg / day was administered orally for 7 days continuously, and the average embryo implantation was found The number was significantly reduced compared with the control group.

example 3

[0039] Sophorin with a purity of 98% was selected as the infertility drug, and the female Brandt's vole on the first day of conception was used as the research object, and the dose of 1800mg / kg / day was continuously administered by intragastric administration for 7 days, and the embryo implantation was found to be average The number was significantly reduced compared with the control group, and had statistical significance (P<0.05). Pathological studies found that after treatment with sophoridoside, the pathological hyperplasia and thickness of the endometrium increased, the structure of the endometrium changed, and the expression level of ERα, a key receptor affecting embryo implantation in the uterus, decreased significantly (P<0.05), PR The expression level of was significantly decreased (P<0.05). The experimental results show that sophorin has significant antifertility effect on female Brandt's voles.

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Abstract

The invention provides a rodenticide for resisting the breeding of the female lasiopodomys brandtii, which adopts sophoricoside as the active ingredient, belonging to the technical field of biological prevention and treatment. The lasiopodomys brandtii mainly inhabits on the meadow with vegetation degradation, the population is strong in fertility, the quantitive variation amplitude each year and each season is great, the breeding is rapid, the collapsing force for the steppe vegetation is strong, therefore, the lasiopodomys brandtii is a formidable enemy for the animal husbandry, and is one of the main rat damages in the Inner Mongolia steppe, and the rat damage severely damages the ecological environment, and also threatens the human health. For a long time, people adopt many methods to control the population quantity of the lasiopodomys brandtii, wherein the method for controlling the population quantity of the injurious rats by adopting the antifertility technology is a novel technology developed in recent years. The invention relates to the female sterile rodenticide prepared by taking sophoricoside as the active ingredient, which is used for controlling the breeding of the lasiopodomys brandtii. Compared with the traditional ecological deratting method and chemical poison bait method, the antifertility technology has the advantages of long acting time, obvious control effect, small toxic and side effects caused to the environment, and the like, and can more effectively inhibit the over-compensatory effect of the population of the injurious rats. If the novel technology is applied to the agriculture-forestry-stockbreeding production, the population quantity of the injurious rats can be effectively controlled, and thus the broad economic benefit is obtained.

Description

technical field [0001] The present invention relates to an anti-fertility rodenticide used for controlling the harmful rat Brandt's vole, in particular to a female sterile agent with sophoraside as an active ingredient for controlling the breeding of the harmful rat Brandt's vole, mainly relating to Sophora japonica A new method of controlling reproduction by keratin affecting the number of implanted embryos in Brandt's vole. Background technique [0002] Grass loss due to prairie rodents accounts for 15%-20%, and it can be as high as 44% in severe disaster years. Occurrence of rodents in the grassland - the soil fertility of the grassland is reduced, a large amount of water is lost, the productivity of the grassland is reduced, resulting in the growth of weeds and the desertification of the grassland, and the environment deteriorates sharply, showing a trend of increasing year by year. [0003] Brandt's vole is distributed in the central and eastern regions of Inner Mongol...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P15/00
CPCA61K31/7048A61K36/22A61K36/48A61K36/489
Inventor 张杰张兴利谢晨文丁仁芳刘筱雪
Owner SICHUAN UNIV
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