Application of cannabinoid compound in preparation of medicine for treating gouty arthritis

A technology of cannabinol and compounds, applied in the field of application of cannabinol compounds in the preparation of drugs for the treatment of gouty arthritis, can solve the problems of prone to gastrointestinal symptoms, large side effects, bone marrow suppression, etc., and achieve the prevention and treatment of hyperuricemia Occurrence of symptoms, relief of symptoms, simple preparation process

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, colchicine, a specific drug for the clinical treatment of acute gouty arthritis, has relatively large side effects, and is prone to adverse re...

Method used

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  • Application of cannabinoid compound in preparation of medicine for treating gouty arthritis
  • Application of cannabinoid compound in preparation of medicine for treating gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take cannabis flowers and leaves, after impurity removal, drying and crushing, CO2 super-extraction, ethanol redissolution after desolvation and impurity removal, pentane elution of the solution after chromatographic separation, collection of eluent, and concentration under reduced pressure , vacuum-dried and pulverized to obtain cannabinoids.

[0034] Get 100 grams of cannabinoids (through a 80-mesh sieve), add 60 grams of microcrystalline cellulose, pass through an 80-mesh sieve three times, mix well, spray 95% ethanol solution, make a soft material, pass through a 40-mesh sieve to granulate, Dry at 60°C for half an hour, divide into 3# capsules, and pack in aluminum-plastic composite packaging.

Embodiment 2

[0036] Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and pulverize, then extract with CO2, remove impurities, and redissolve in ethanol. The solution is separated by chromatography and eluted with pentane. liquid, concentrated under reduced pressure, dried in vacuo, and pulverized to obtain cannabinoids.

[0037] The cannabinoid compound powder is taken, 5-20% of dry starch and 1-5% of magnesium stearate are added, mixed, granulated, dried and compressed to obtain tablets.

Embodiment 3

[0039] Repeat Example 2, with the following differences: take the cannabinoid compound powder, add sucrose water and a conventional amount of preservatives, stabilizers and other auxiliary materials. Filter, sterilize, and divide into 10mL bottles to make oral liquid.

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Abstract

The invention discloses application of a cannabinoid compound in preparation of medicine for treating gouty arthritis. The inventor finds that the cannabinoid compound has the function of remarkably reducing creatinine and uric acid in serum of a hyperuricemia mouse for the first time, and hyperuricemia is avoided. Meanwhile, cell factors of an organism are adjusted, effective inflammation resistance are achieved, gouty arthritis symptoms are relieved, and the functions of treating and preventing gouty arthritis are achieved. The invention further provides a medicinal preparation of the cannabinoid compound for treating gouty arthritis and a corresponding dosage form of the medicinal preparation, clinically used medicines of different dosage forms can be prepared through a conventional preparation method, and use is convenient.

Description

technical field [0001] The present invention relates to the new application of cannabinol compounds extracted from cannabis in medicine, in particular to the application of cannabinol compounds in the preparation of medicines for treating gouty arthritis. Background technique [0002] Gouty arthritis is a class of diseases caused by purine metabolism disorders in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/352A61K31/192A61K36/60A61P19/02A61P19/06A61P29/00
CPCA61K31/05A61K31/192A61K31/352A61K36/60A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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