A kind of water-soluble synergistic composition containing amoxicillin and its application

Abstract

The invention discloses a water-soluble synergistic composition containing amoxicillin and application thereof. The water-soluble synergistic composition is prepared from the following ingredients in parts by mass: 10 to 30 parts of amoxicillin, 1 to 30 parts of sulbactam sodium, 1 to 11 parts of probenecid sodium, 1 to 15 parts of EDTA-2Na, 1 to 10 parts of PVP K30, 1 to 10 parts of PEG-6000, 1 to 30 parts of SDS and 1 to 40 parts of lactose. The composition is crashed into super micro-powder with the grain diameter being 1000 to 2000 meshes (1.3 to 6.5mum) by an ultramicro pulverization technique; then, the super micro-powder is made into powder, granules or other clinically acceptable dosage forms according to requirements for preventing and treating respiratory tract and digestive tract diseases of animals such as pigs and children. The composition has good water solubility and can realize administration in a water drinking mode. The water-soluble synergistic composition has the advantage that the clinical use effect of the amoxicillin is improved through three paths of improving the water solution stability, prolonging the plasma concentration maintaining time and enhancing the resistance on beta-lactamase.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a water-soluble synergistic composition containing amoxicillin and an application thereof. Background technique [0002] Since the advent of penicillin drugs in 1941, penicillin drugs have been irreplaceable by other drugs such as high efficiency, low toxicity, strong selectivity, broad antibacterial spectrum, and good distribution in the body, whether in human clinical or animal clinical, All of them have been widely used in the world and created huge social benefits. [0003] Amoxicillin is the most commonly used semi-synthetic penicillin broad-spectrum β-lactam antibiotics. The mechanism of action is that the β-lactam ring in the drug molecule binds to the transpeptidase in the bacteria to inactivate it and cut off the bacteria. The only way to rely on transpeptidase to synthesize glycopolypeptides to build cell walls makes bacterial cells quickly becom...

AI Technical Summary

Problems solved by technology

Because amoxicillin is easy to decompose in aqueous solution, it must be used up in a short time when administered with drinking water, otherwise the efficacy of the drug will be greatly reduced, which brings inconvenience to clinical medication and increases the cost of medication

[0006] 2. Amoxicillin absorbs quickly after oral administration, has low protein binding rate, short half-life, and will soon be metabolized from the body. In order to maintain the drug concentration and prolong the action time, the administration cycle must be shortened and the administration frequency increased.

Although the technical solution provided by the above-mentioned patent can effectively solve the problem of amoxicillin drug resistance, it does not solve the problems of poor water solubility, unstable aqueous solution and fast metabolism of amoxicillin

At the same time, potassium clavulanate has strong hygroscopicity, which puts forward higher requirements for the production environment and increases the production cost

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