Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of a phenylpropanoid compound in the preparation of medicines for treating inflammatory diseases

A technology for inflammatory diseases and compounds, applied in the field of medicine, can solve problems such as complex biological effects, achieve high purity, simple extraction and separation methods, and easy synthesis

Active Publication Date: 2018-09-25
ZHUZHOU QIANJIN PHARMA
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many target cells for IL-6, including macrophages, liver cells, resting T cells, activated B cells, and plasma cells; its biological effects are also very complex

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of a phenylpropanoid compound in the preparation of medicines for treating inflammatory diseases
  • Application of a phenylpropanoid compound in the preparation of medicines for treating inflammatory diseases
  • Application of a phenylpropanoid compound in the preparation of medicines for treating inflammatory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of phenylpropanoid compounds

[0050] The present embodiment provides a kind of preparation method of phenylpropanoid compound shown in formula (I), comprises the following steps:

[0051] S1. Take 50kg of large leaves, use the roots as raw materials, dry them, and cut them into small pieces. After 8 times of 60% ethanol reflux extraction for 3 times, each time for 2 hours, the extracts were combined, concentrated until there was no alcohol smell, and the extract was ready for use;

[0052] S2. Dissolve the concentrated extract in step S1 in 10 L of water, use D101 macroporous adsorption resin column to elute it, the eluent is water, elute 3 column volumes, collect the eluent, and name it as MM -1, spare;

[0053] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volume ratio is 25:75, eluting 18 column volumes, press Collect a fraction of the eluent ev...

Embodiment 2

[0056] Example 2 Preparation of phenylpropanoid compounds

[0057] The present embodiment provides a kind of preparation method of phenylpropanoid compound shown in formula (I), comprises the following steps:

[0058] S1. Take 40kg of large leaves, use the roots as raw materials, dry them, and cut them into small pieces. After 6 times of 50% ethanol reflux extraction for 2 times, each time for 1 hour, the extracts were combined, concentrated until there was no alcohol smell, and the extract was used for later use;

[0059] S2. Dissolve the concentrated extract in step S1 in 5L of water, use D101 macroporous adsorption resin column to elute it, the eluent is that the volume ratio of ethanol and water is 15:85, and the elution is carried out for 3 column volumes , the eluate was collected and named as MM-1 for use;

[0060] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volume rati...

Embodiment 3

[0063] Example 3 Preparation of phenylpropanoid compounds

[0064] The present embodiment provides a kind of preparation method of phenylpropanoid compound shown in formula (I), comprises the following steps:

[0065] S1. Take 60kg of large leaves, use the roots as raw materials, dry them, and cut them into small pieces. 7 times the amount of 70% ethanol reflux extraction for 4 times, each time for 3 hours, the extracts were combined, concentrated until there was no alcohol smell, and the extract was used for later use;

[0066] S2. Dissolve the concentrated extract in step S1 in 8L of water, use D101 macroporous adsorption resin column to elute it, the eluent is that the volume ratio of ethanol and water is 10:90, and the elution is carried out for 3 column volumes , the eluate was collected and named as MM-1 for use;

[0067] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volum...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of medicines, and discloses an application of phenylpropanoids compounds in preparation of medicines for treating inflammatory diseases. The phenylpropanoid compounds are indicated to be able to inhibit expression effects of inflammatory cytokines TNF-alpha, IL-1beta and IL-6, thereby having anti-inflammatory activity, and providing a direction for development of medicines for treating inflammatory diseases, such as cervicitis, endometritis, pelvic inflammation, mastitis, sphagitis and / or arthritis and other diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a phenylpropanoid compound in the preparation of medicines for treating inflammatory diseases. Background technique [0002] The components extracted and separated from natural medicines have various structures and significant activities. Separation, purification, structural modification, transformation and total synthesis of the components have always been a main idea in the development of new drugs. [0003] TNF-α: It is a cytokine that can directly kill tumor cells without obvious toxicity to normal cells. It is one of the biologically active factors with the strongest direct tumor killing effect found so far, but its toxic and side effects are also very serious. [0004] IL-1β: At local low concentrations, it can co-stimulate the activation of APC and T cells, promote the proliferation of B cells and secrete antibodies, and perform immune regulation. En...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034C07H15/203C07H1/08A61K36/738A61K36/758A61K36/486A61K36/29A61K36/19A61K36/232A61K36/344A61P15/14A61P15/00A61P11/04A61P19/02
CPCA61K31/7034A61K36/19A61K36/232A61K36/29A61K36/344A61K36/486A61K36/738A61K36/758C07H1/08C07H15/203A61K2300/00
Inventor 龚云刘逆夫夏博候彭开锋李亚梅佘娜白璐
Owner ZHUZHOU QIANJIN PHARMA