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Application of phenylpropanoid compound and medically-acceptable salt thereof in preparing medicine for treating inflammatory diseases

A technology for inflammatory diseases and compounds, applied in the field of medicine, can solve problems such as complex biological effects, and achieve the effects of high purity, simple structure, and simple extraction and separation methods.

Active Publication Date: 2016-06-22
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many target cells for IL-6, including macrophages, liver cells, resting T cells, activated B cells, and plasma cells; its biological effects are also very complex

Method used

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  • Application of phenylpropanoid compound and medically-acceptable salt thereof in preparing medicine for treating inflammatory diseases
  • Application of phenylpropanoid compound and medically-acceptable salt thereof in preparing medicine for treating inflammatory diseases
  • Application of phenylpropanoid compound and medically-acceptable salt thereof in preparing medicine for treating inflammatory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Preparation of phenylpropanoids

[0058] This embodiment provides a method for preparing the phenylpropanoid compound represented by formula (I), which includes the following steps:

[0059] S1. Take 50 kg of big leaves, take the roots as raw materials, dry, and cut into small pieces. Reflux with 8 times the amount of 60% ethanol for 3 times, 2 hours each time, combine the extracts, concentrate until there is no alcohol taste, and obtain the extract for use;

[0060] S2. Dissolve the concentrated extract in step S1 in 10L of water, and use D101 macroporous adsorption resin column to elute it, the eluent is water, elute 3 column volumes, collect the eluent and name it MM -1, spare;

[0061] S3. The fraction MM-1 collected in step S2 is eluted by reversed-phase ODS column chromatography. The eluent is a methanol-water system with a volume ratio of 25:75, and 18 column volumes are eluted. Collect the eluent of one fraction for every 3 column volumes, and collect 6 frac...

Embodiment 2

[0064] Example 2 Preparation of phenylpropanoids

[0065] This embodiment provides a method for preparing the phenylpropanoid compound represented by formula (I), which includes the following steps:

[0066] S1. Take 40kg of big leaves, take root as raw material, dry, and cut into small pieces. Reflux with 6 times the amount of 50% ethanol for 2 times, 1 hour each time, combine the extracts, concentrate until there is no alcohol taste, and obtain the extract for later use;

[0067] S2. Dissolve the concentrated extract in step S1 in 5L of water, and use D101 macroporous adsorption resin column to elute it. The eluent is ethanol and the volume ratio of water is 15:85, and the elution is 3 column volumes. , Collect the eluate and name it MM-1 for use;

[0068] S3. The fraction MM-1 collected in step S2 is eluted by reversed-phase ODS column chromatography. The eluent is a methanol-water system with a volume ratio of 20:80, and 18 column volumes are eluted. Collect the eluent of one fr...

Embodiment 3

[0071] Example 3 Preparation of phenylpropanoids

[0072] This embodiment provides a method for preparing the phenylpropanoid compound represented by formula (I), which includes the following steps:

[0073] S1. Take 60 kg of big leaves, take root as raw material, dry, and cut into small pieces. Seven times the amount of 70% ethanol was refluxed and extracted 4 times for 3 hours each time, the extracts were combined and concentrated until there was no alcohol taste, and the extract was obtained for use;

[0074] S2. Dissolve the concentrated extract in step S1 in 8L of water, and use D101 macroporous adsorption resin column to elute it. The eluent is ethanol and the volume ratio of water is 10:90, and the elution is 3 column volumes. , Collect the eluate and name it MM-1 for use;

[0075] S3. The fraction MM-1 collected in step S2 is eluted by reversed-phase ODS column chromatography. The eluent is a methanol-water system with a volume ratio of 30:70, and 18 column volumes are eluted...

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Abstract

The invention relates to the technical field of medicine, and discloses application of a phenylpropanoid compound and medically-acceptable salt thereof in preparing medicine for treating inflammatory diseases. The phenylpropanoid compound shows the effect of inhibiting expression of inflammatory cytokines TNF-alpha, IL-1beta and IL-6 and has an inhibiting effect on hydroxyl radicals (-OH), and thus the phenylpropanoid compound has anti-inflammatory activity and anti-oxidative activity and provides direction for development of medicine for treating inflammatory diseases such as cervicitis, endometritis, pelvic inflammation, mastitis, sphagitis and / or arthritis.

Description

Technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a phenylpropanoid compound and a pharmaceutically acceptable salt thereof in the preparation of a medicine for treating inflammatory diseases. Background technique [0002] The components extracted and separated from natural medicines have diverse structures and significant activities. Their separation, purification, structural modification, transformation and total synthesis have always been a main idea for new drug development. [0003] TNF-α: It is a cytokine that can directly kill tumor cells without obvious toxicity to normal cells. It is one of the biologically active factors with the strongest direct tumor killing effect found so far, but its toxic side effects are also very serious. [0004] IL-1β: Co-stimulates APC and T cell activation at local low concentrations, promotes B cell proliferation and secretion of antibodies, and performs immune regulation. Wh...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61K36/758A61P29/00A61P19/02A61P15/00A61P15/14A61P11/04C07H15/203C07H1/08
CPCA61K31/7034A61K36/19A61K36/232A61K36/29A61K36/344A61K36/48A61K36/486A61K36/738A61K36/758C07H1/08C07H15/203A61K2300/00
Inventor 张鹏彭开锋林丽美伍实花夏博候佘娜颜利玲
Owner ZHUZHOU QIANJIN PHARMA
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