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Application of mastic and myrrh in preparing medicine for preventing and treating nerve pathological pain diseases

A technology of neuropathy and frankincense, applied in nervous system diseases, drug combinations, pharmaceutical formulas, etc., to achieve the effect of inhibiting pain response and important economic value

Inactive Publication Date: 2016-11-09
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Previous studies have found that this topical capsaicin shows consistent effects only on postherpetic neuralgia

Method used

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Embodiment 1

[0029] Embodiment 1 frankincense and myrrh pharmacological activity screening

[0030] 1. Modeling method

[0031] Neuropathic pain is a difficult-to-treat pain condition caused by damage or abnormality of the nervous system. The sciatic nerve ligation model is the most commonly used animal model of neuropathic pain. The present invention uses 1% pentobarbital (10mg / kg, intraperitoneal injection) to anesthetize the mouse and fix it on the operating table, cut the skin of the middle part of the thigh of the right lower limb of the mouse after clipping and disinfection, and bluntly separate the muscles to expose the sciatic nerve. Two 4-0 silk sutures were used to ligate the bifurcation, with an interval of about 1 mm. The strength of the ligation should be such that it can cause slight tremors in the calf muscles and slow down, but not block, the circulation through the superficial blood vessels. The wounds were rinsed with normal saline, the incisions were sutured layer by l...

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Abstract

The invention discloses application of mastic and myrrh in preparing medicine for preventing and treating nerve pathological pain diseases. Based on the existing pharmacological activity of mastic and myrrh, new clinical effects of mastic and myrrh are screened through deep research via a large quantity of experiments. According to the application, an animal model of nerve pathological chronic pain caused by ligation of the sciatic nerve is used for researching the suppression effect of mastic-myrrh aqueous extract on the pain sense of mice, and experiment results show that after the model for ligation of the sciatic nerve is implemented for 7 days, obvious pain reactions of mice can be caused, while the pain reactions of mice can be remarkably suppressed through oral administration of the mastic-myrrh aqueous extract. The mastic-myrrh aqueous extract provided in the application can be prepared into high-efficiency and low-toxicity treatment medicine for preventing and treating nerve pathological pain, has significant economic value and is worthy of application and popularization.

Description

technical field [0001] The invention relates to a traditional Chinese medicinal pair, in particular to the application of the medicinal pair composed of frankincense and myrrh in the preparation of medicines for preventing and treating neuropathic pain diseases. Background technique [0002] Neuropathic pain is currently defined as pain that is a direct result of a disease or lesion affecting the somatosensory system. The main clinical features are spontaneous pain, hyperalgesia, allodynia, and paresthesia, which can be caused by surgery, trauma, nervous system disease or systemic disease involving the nervous system, infection, etc. Epidemiological surveys show that the incidence of neuropathic pain in the general population is 6% to 8%; neuropathic pain is severe and mostly chronic, and a considerable number of patients have poor curative effect, which seriously affects the quality of life and has gradually become a global burden. disease. In recent years, neuropathic pa...

Claims

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Application Information

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IPC IPC(8): A61K36/328A61P25/00A61K36/324
CPCA61K36/324A61K36/328A61K2236/331A61K2236/51A61K2300/00
Inventor 于光唐宗湘王长明宿树兰
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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