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Application of cannabinoid in preparing medicines for treating epilepsy

A technology of anesthetics and drugs, which is applied in the field of preparation of drugs for the treatment of epilepsy, can solve the problem of no obvious improvement in the pathological process of epilepsy, and achieve the effect of prolonging the incubation period and prolonging the end point of death

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the entire pathological process of epilepsy has not been significantly improved

Method used

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  • Application of cannabinoid in preparing medicines for treating epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take the mature hemp seed, dry it, remove impurities, and pulverize it for later use; extract the pulverized hemp seed material with ethanol (under the condition of 60~85℃, heat and extract 2 times, 1~3 hours each time) ), the ethanol concentration is 95% to 100% (V / V), and the material-to-liquid ratio is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the hemp seed extract of industrial hemp.

[0030] Take a mixture of industrial hemp flowers, leaves, and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled to be 40-50°C, the extraction time is 30-90min, t...

Embodiment 2

[0033] Repeat Example 1, with the following differences: when ethanol is used to extract hemp seeds from industrial hemp, the extraction is carried out at room temperature, and each batch of materials is extracted twice for 7 to 10 days each time. A mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:1:1 was taken as the extraction raw material of industrial hemp cannabinoids.

[0034] Take 0.3 part of industrial hemp hemp seed extract and 99.7 parts of industrial hemp cannabinoid, mix well, and obtain the required pannaphine A.

Embodiment 3

[0036] Repeat Example 1, there are the following differences: when ethanol is used to extract industrial hemp hemp seeds, ultrasonic-assisted extraction is adopted, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 3:2:1 was taken as the raw material for extracting hemp cannabinoids.

[0037] Take 99.7 parts of industrial hemp hemp seed extract and 0.3 part of industrial hemp cannabinoid, mix well to obtain the required pannaphine C.

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Abstract

The invention discloses an application of cannabinoid in preparing medicines for treating epilepsy. The cannabinoid is prepared by uniformly mixing 0.3-99.7 parts by weight of an industrial hemp semen cannabis extract and 99.7-0.3 parts by weight of industrial hemp cannabinoid. Experiments prove that the cannabinoid can prolong the incubation period of clonic seizure, the incubation period of generalized tonic-clonic seizure and a mouse end point. The cannabinoid has a protective effect on a mouse of a pentamethazol-caused epilepsy model. As for clinical treatment effects, the cure rate of the cannabinoid reaches 85% or above and the effective rate reaches 97% or above; therefore, the cannabinoid has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of industrial hemp utilization, and in particular relates to the application of a pharmaceutical composition prepared by using industrial hemp as the main raw material in the preparation of a medicine for treating epilepsy. Background technique [0002] Hemp has a long history of cultivation. Ancient hemp was mainly used to make processing ropes, fishing nets, clothing and papermaking raw materials, as well as oil and food. With the development and progress of society, it has been found that marijuana contains a toxic ingredient (tetrahydrocannabinol) that can make people addicted to hallucinations. Many countries in Europe and the United States have banned marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and cultivated low-toxic cannabis varieties and were promoted for cultivation. In 1990, the European Community took the lead in re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P25/08
CPCA61K36/60A61K2236/333A61K2236/37A61K2236/51A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司