A non-invasive infrared compound absorption method for precise measurement of blood sugar changes

Abstract

The invention discloses a method for accurately measuring blood sugar changes through non-invasion infrared composite absorption. The method comprises the steps that firstly, on the basis of glucose molecule vibration and a COMSOL analog simulation result, the selective wavelength of a composite detection source is determined; then, by means of biological tissue selectivity transmission and blood sugar characteristic absorption, a mathematic relation between the intensity of transmitted beams and the sugar concentration is built, and real-time effective dynamic parameters are provided for a model by means of the thermal radiation calibration temperature of a human testing portion, so that errors caused by differences of the portion and a body to be measured are reduced; finally, the glucose chirality optical rotation phenomenon is used for eliminating a light intensity direct current item in a vertical polarization mode, the sensitivity is improved, and dynamic correction low-concentration blood sugar non-invasion infrared detection is achieved.

Description

technical field [0001] The invention relates to a non-invasive method for measuring blood sugar, in particular to a method for obtaining blood sugar concentration by using a compound detection source of near-infrared absorption peaks and mid-infrared characteristic wavelengths to detect infrared spectrum absorption of human earlobe tissue. Background technique [0002] According to the latest "Diabetes Map" released by the International Diabetes Federation in 2015, there are as many as 109.6 million adults with diabetes in China, and a total of 51 billion US dollars in diabetes-related medical expenses. Therefore, there is a huge demand for accurate, efficient and convenient blood glucose measurement and monitoring equipment for hyperglycemia and diabetes patients, and even non-diseased patients who intend to manage and monitor their own health conditions. However, the traditional blood glucose meter requires frequent needles to collect blood, and it is necessary to ensure t...

AI Technical Summary

Problems solved by technology

The measurement site of the polarimetry must be the eyeball, and installing the measurement device on the eyeball will bring strong discomfort to the patient, it is inconvenient to wear and there is a risk of infection

[0004] At present, the research on infrared non-invasive blood sugar measurement is to split the detection band into two bands of near-infrared and mid-infrared. In the stage of using Fourier transform infrared spectrometer to detect the simulated blood samples in the sample pool, there is no detailed theoretical analysis on the measurement of blood glucose by infrared light

Because the accuracy of infrared blood glucose measurement is greatly affected by the temperature of the environment and the individual, and the existing infrared blood glucose measurement method has not proposed a detailed mathematical model and dynamically combined with temperature factors, there are objective errors

At the same time, the existing measurement methods can only measure very high blood sugar concentration changes (at intervals of 100mg / dL) more accurately

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