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Baicalein aluminum capsule and preparation method thereof

A technology of baicalein aluminum and capsules, which is applied in the field of baicalein aluminum capsules and its preparation, can solve the problems of low content of active ingredients, large dosage for patients, inconvenient taking, etc., and achieves stable active ingredients, strong applicability, and drying efficiency. low effect

Inactive Publication Date: 2016-12-07
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method in the prior art has rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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  • Baicalein aluminum capsule and preparation method thereof
  • Baicalein aluminum capsule and preparation method thereof
  • Baicalein aluminum capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 1000g of Scutellaria baicalensis coarse powder, add 10 times the weight of medicinal materials in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of medicinal materials in water, decoct for 1 hour, filter out the medicinal liquid, combine two decoctions Boil liquid, concentrate to 60°C relative density is 1.05, add ethanol to make the volume percentage of alcohol content reach 75%, stir, stand still, filter, when the filtrate is concentrated to 65°C, relative density is 1.25, and recover ethanol to obtain concentrate , slowly add saturated alum aqueous solution to form a precipitate, filter, wash the precipitate with water until no sulfate radicals are present, dry, pulverize, granulate, and pack into gelatinous paste to obtain baicalein aluminum capsules.

[0021] See figure 1 : the preparation method of the baicalein aluminum capsule, the above-mentioned twice concentrated use device, comprising a tank body 1, a feed port 2 arranged on the...

Embodiment 2

[0030]According to the standard issued by the ministry: Take the coarse powder of Scutellaria baicalensis, put it into hot water 10 to 15 times the amount of raw materials and soak it twice, combine the soaking liquid, filter, collect the filtrate, slowly add saturated alum aqueous solution while stirring, make a precipitate, and filter , and the precipitate was washed with water until no sulfate radicals were present. Drain, dry below 80°C, pulverize, granulate, pack into capsules, and make 750 capsules.

[0031] Common equipment is used for drying.

Embodiment 3

[0033] Baicalin Content Determination Experimental Research Data in Baicalein Aluminum Capsules of the Present Invention

[0034] 1.1 Experimental drug: baicalein aluminum capsule of the present invention: prepared according to the method in Example 1. The control group prepared baicalein aluminum capsules according to Example 2 using a common drying method.

[0035] 1.2 Instruments: High-performance liquid chromatography system includes high-performance liquid chromatography (Waters 515); P200 high-pressure pump; Waters2487 ultraviolet detector and GJ605 high-pressure six-way sampling valve; chromatographic column is ODSC18 (3.9mm×150mm, 5μm ); data acquisition and processing using HS chromatographic data workstation V4.0+ (Hangzhou Yingpu Technology)

[0036] 1.3 Determination conditions: High performance liquid chromatography is adopted, the chromatographic column is ODSC18 (3.9mm×150mm, 5μm), the mobile phase is methanol: water: phosphoric acid (47:5 2:0.2), and the detec...

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PUM

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Abstract

The invention provides a baicalein aluminum capsule, wherein a preparation method comprises the following steps: preparing 1000g of coarse radix scutellariae powder, soaking the coarse powder in water which is 10 times the total weight of the medicinal material (the radix scutellariae) for 0.5h, conducting decocting for 1h, and conducting filtering; decocting medicine dregs in water which is 8 times the total weight of the medicinal material for 1h, and filtering medicine liquid; combining two times of decoctions, and conducting concentrating until relative density is 1.05 at 60 DEG C; adding ethanol until an alcohol content is 75% by volume; conducting filtering, standing by and filtering; concentrating a filtrate until relative density is 1.25 at 65 DEG C, and recovering the ethanol, so that a concentrated solution is obtained; slowly adding a saturated alum water solution until a precipitate is formed, conducting filtering, and washing the precipitate by virtue of water until no sulfate radical exists; and conducting drying, crushing and granulating, and adding a capsule paste, so that the baicalein aluminum capsule is obtained. The prepared baicalein aluminum capsule is high in baicalin content and the baicalein aluminum capsule is capable of inhibiting the proliferation of swiss mouse embryonic NIH/3T3 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a baicalein aluminum capsule and a preparation method thereof. Background technique [0002] Baicalein Aluminum Capsules, clear away heat and detoxify, dry dampness and relieve diarrhea. For enteritis, dysentery. The preparation method in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. Contents of the invention [0003] Purpose of the invention: in order to solve the above problems, the purpose of the present invention is to provide a kind of baicalein aluminum capsule and preparation method thereof. [0004] Technical scheme: the purpose of the present invention is achieved by the following scheme: [0005] A baicalein aluminum capsule, the preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K9/48A61P35/00B01D1/00B01D1/30B01F13/10F26B21/00F26B23/06F26B21/10F26B25/00A61K33/06
CPCB01D1/00B01D1/0017B01D1/30F26B21/00F26B21/10F26B23/06F26B25/00A61K9/4841A61K33/06A61K36/539A61K2236/331A61K2236/39B01F33/402B01F33/406A61K2300/00
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
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