Application of potentilla anserine polysaccharides to preparing medicines for treating renal injury

A technology for the treatment of japonica polysaccharides and kidney damage, which is applied in the field of traditional Chinese medicine to achieve the effect of increasing anti-oxidation, easy acquisition, and simple production and preparation process

Inactive Publication Date: 2016-12-14
LANZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no Chinese medicinal material with special curative effect against chronic cadmium damage.

Method used

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  • Application of potentilla anserine polysaccharides to preparing medicines for treating renal injury
  • Application of potentilla anserine polysaccharides to preparing medicines for treating renal injury
  • Application of potentilla anserine polysaccharides to preparing medicines for treating renal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method and content determination of juniper polysaccharide:

[0022] Weigh the fern, wash, dry naturally, crush, add petroleum ether (the solid-liquid ratio of fern to petroleum ether is 1g: 10 ml) reflux at 40°C for 2 hours to remove the surface fat, weigh the filter residue quantitatively, add water As a solvent, use a solid-liquid ratio of 1:25, reflux extraction at 100°C for 1 hour, repeat 3 times, combine the filtrate and concentrate to 1 / 4 of the volume of the original filtrate; add 4 times the volume of 95% ethanol to the concentrated solution, and let it stand for 24 hours The flocculent precipitate was collected by centrifugation, and the precipitate was washed twice with 4 times the volume of absolute ethanol and acetone respectively, and freeze-dried to obtain the crude polysaccharide of Bracken japonicus. The crude polysaccharides of Bracken japonica and distilled water were prepared into a crude polysaccharide solution of 0.5% by mass volume...

Embodiment 2

[0024] Protective effect of Juna polysaccharide on kidney injury caused by chronic cadmium deposition:

[0025] 1. Experimental grouping and steps:

[0026] 40 male BalB / c mice (20±2g) were randomly divided into normal control group, experimental control group, pure Bracken polysaccharide group and Bracken polysaccharide protection group. The mice in Juema polysaccharide protection group were given intraperitoneal injection of Juema polysaccharide aqueous solution (10 mg / kg Juema polysaccharide aqueous solution was injected intraperitoneally at 9:00 every morning for a total of 30 days); intraperitoneal injection of cadmium chloride aqueous solution was given (after 5 consecutive days of polysaccharide injection, every afternoon 4:00 injection of 2 mg / kg cadmium chloride aqueous solution, a total of 25 days). The experimental control group was injected with the same amount of normal saline in the morning and 2 mg / kg cadmium chloride aqueous solution in the afternoon. Simple ...

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Abstract

The invention discloses application of potentilla anserine polysaccharides to preparing medicines for treating renal injury. The application has the advantages that each potentilla anserine polysaccharide is one of main chemical ingredients in potentilla anserine, has antioxidant, anti-aging, immunity regulating, antibacterial and blood sugar reducing biological activity and the like, processes for producing and preparing the potentilla anserine polysaccharides are simple, and the potentilla anserine polysaccharides are easily available and are free of injury toxicity as discovered in in-vivo and in-vitro toxicological experiments; as indicated via experimental verification, the antioxidant and anti-apoptosis capacity of tissue cells can be obviously improved by the potentilla anserine polysaccharides when the medicines are used for treating renal injury due to chronic cadmium deposition, visceral indexes due to cadmium-induced injury can be reduced, chronic inflammatory response, lipid peroxidation, tissue fibrosis and the like can be relieved, and protection effects can be realized for renal injury due to chronic cadmium deposition.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicines, in particular to the application of juniper polysaccharides in the preparation of medicines for treating kidney damage. Background technique [0002] Cadmium (Cd), as a toxic heavy metal, is one of the common environmental pollutants and is a non-essential element in the body. It often exists together with zinc in nature. When the environment is polluted by Cd, Cd can be enriched in organisms through the food chain, and its half-life in the human body is as long as 10-20 years. Long-term low-dose exposure can cause multiple organ toxicity, even teratogenicity and mutagenesis, which has attracted widespread attention in the toxicology community. The International Agency for Research on Cancer has determined that Cd is a confirmed carcinogen for lung cancer and prostate cancer in humans and experimental animals, and the US Poison Control Committee (ATSDR) has l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P13/12A61P39/02C08B37/00
CPCA61K31/715C08B37/0003
Inventor 白德成沈蓉刘迪生侯晨晨刘迪程菊
Owner LANZHOU UNIVERSITY
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