A microfluidic chip for in situ control culture of animal tissues

A technology of microfluidic chips and animal tissues, which is applied in tissue cell/virus culture devices, biochemical equipment and methods, biochemical instruments, etc., can solve the problems of poor scalability and low chip integration, and achieve high The effect of integration

Active Publication Date: 2018-06-15
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the current tissue culture chips are not highly integrated and scalable

Method used

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  • A microfluidic chip for in situ control culture of animal tissues
  • A microfluidic chip for in situ control culture of animal tissues
  • A microfluidic chip for in situ control culture of animal tissues

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Embodiment Construction

[0026] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the principle of the present invention.

[0027] see Figure 1 to Figure 7 . It should be noted that the diagrams provided in this embodiment are only used to illustrate the basic principles, component structures, working processes and effects of the present invention, so that only the components related to the present invention are shown in the diagrams rather than according to the actual The number, formation and dimensional drawing of components during implementation, ...

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Abstract

The invention provides a micro-fluidic chip for in-situ contrast culture of animal tissues. The micro-fluidic chip is provided with a micro-fluidic network structure and a plurality of fluid inlets, wherein the micro-fluidic network structure adopts an array type and is used for culturing the animal tissues; the flow inlets are connected with a tissue culture array; by utilizing the laminar state of fluid from the inlets in a micro-fluidic passage and the gathering function of a tissue suspension from the middle inlet, the tissues are distributed to each row of culture units by multiple levels of Y-shaped flow separating areas, and each culture unit is used for fixing, culturing and observing the tissues; the different types of culture liquids are inputted by different inlets, the flow rate is adjusted, the tissues fixed in different rows are cultured in different types of culture liquids, and then the in-situ contrast culture of tissues on the same micro-fluidic chip is realized. The micro-fluidic chip has the advantage that by utilizing transparent material, the real-time monitoring under a microscope and the in-situ analysis of dynamic growth and differentiation process of tissues can be performed, so as to study the dynamics parameters of structure and function of animal tissues under the condition of stimulation by different culture environments.

Description

technical field [0001] The invention provides a microfluidic chip for in-situ control culture of animal tissues, which belongs to the technical fields of microfluidic technology and animal tissue culture analysis. technical background [0002] Animal tissue culture refers to taking out tissues or organs from animals, simulating the physiological environment conditions in the body, and making the isolated tissues or organs survive, grow, and maintain their differentiation, structure and ( or) function is an important technical basis of modern animal tissue engineering. Animal tissue culture has extensive scientific research and practical application value in biological, medical and pharmaceutical fields such as three-dimensional tissue and organ engineering, embryonic stem cell engineering, animal cloning, large-scale preparation of animal cell products, and in vitro drug testing between cells and animals. [0003] Traditional animal tissue culture techniques usually use cul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00
CPCC12M23/16C12M23/34
Inventor 朱真陈攀陈炜捷田倍通方磊
Owner SOUTHEAST UNIV
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