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Method and system for grouping liver transplantation prognostic conditions for patient with hepatocellular carcinoma, and kit

A technology for hepatocellular carcinoma and liver transplantation, used in analytical materials, biomaterial analysis, measurement devices, etc.

Active Publication Date: 2017-01-04
冯骥良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the relationship between the expression of cytokeratin 19 (CK19) or glypican-3 (GPC3) in hepatocellular carcinoma and postoperative tumor metastasis and recurrence has been reported, the combined detection of CK19 or GPC3 has a significant effect on hepatocellular carcinoma. Subclassification and stratification of patient outcomes have not been published

Method used

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  • Method and system for grouping liver transplantation prognostic conditions for patient with hepatocellular carcinoma, and kit
  • Method and system for grouping liver transplantation prognostic conditions for patient with hepatocellular carcinoma, and kit
  • Method and system for grouping liver transplantation prognostic conditions for patient with hepatocellular carcinoma, and kit

Examples

Experimental program
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Effect test

Embodiment 1

[0088] Example 1 The grouping method of the present invention is established by identifying risk factors that predict recurrence-free survival in HCC patients

[0089] 1. Patients and Methods

[0090] Patient and Tissue Samples

[0091] From January 2007 to November 2010, 117 cases of hepatocellular carcinoma transplanted in Beijing You'an Hospital Affiliated to Capital Medical University that met the Milan criteria were collected. This study complied with the Declaration of Helsinki and was approved by the local ethics committee, and all subjects signed informed consent. All cases had no chemotherapy, radiotherapy or interventional therapy before operation. The above-mentioned Milan criteria are defined as: a single tumor does not exceed 5 cm in diameter; there are less than 3 multiple tumors and the largest diameter does not exceed 3 cm; there is no invasion of large vessels, and no lymph node or extrahepatic metastasis.

[0092] The clinical and histological data of HC...

Embodiment 2

[0122] Example 2 Prognostic grouping of patients with hepatocellular carcinoma meeting the Milan criteria based on liver biopsy before liver transplantation (technical scheme 1)

[0123] A total of 23 liver transplant cases of hepatocellular carcinoma patients who met the Milan criteria were collected from a tertiary hospital in Haidian District, Beijing. All patients had undergone liver biopsy before liver transplantation, and patients were obtained from the laboratory and pathology databases. The concentration of AFP in serum and the results of immunohistochemical staining of CK19 and GPC3 were obtained from the medical imaging department.

[0124] The method, system and kit provided by the present invention were used to group the prognosis of patients with hepatocellular carcinoma meeting the Milan criteria, and the AFP concentration threshold in serum was set at 321 ng / mL. The results are shown in Table 6 below.

[0125]

[0126]

[0127] See the specific implement...

Embodiment 3

[0130] Example 3 Prognostic grouping of hepatocellular carcinoma patients meeting the Milan criteria based on gross specimens after liver transplantation after liver transplantation (technical scheme 2)

[0131] 36 cases of liver transplantation of patients with hepatocellular carcinoma meeting the Milan criteria were collected from a tertiary first-class hospital in Haidian District, Beijing, including 23 patients who underwent liver biopsy before transplantation in Example 1. The database of the pathology department obtained the AFP concentration in the patient's serum and the results of immunohistochemical staining of CK19 and GPC3, and obtained the patient's imaging information from the medical imaging department.

[0132] The method, system and kit provided by the present invention were used to group the prognosis of patients with hepatocellular carcinoma meeting the Milan criteria, and the threshold value of AFP concentration in serum was set at 321 ng / mL. The results ...

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Abstract

The invention relates to a method and system for grouping liver transplantation prognostic conditions for a patient with hepatocellular carcinoma, and a kit, and provides a method of carrying out stricter liver transplantation preoperative receptor screening on a patient with hepatocellular carcinoma meeting 'Milan criteria' and a method of predicting tumor recurrence and metastasis risks in a liver transplantation postoperative patient, based on the joint detection of cytokeratin 19 (CK19) and glypican-3 (GPC3) and the patient's serum alpha-fetoprotein (AFP) concentration as a technical index. According to the method, it is possible to reduce post-transplantation tumor recurrence, and it is also possible to guide clinicians to carry out intensive monitoring or early treatment for post-liver transplantation cases with high metastasis and recurrence risks.

Description

technical field [0001] The present invention belongs to the field of precision medicine, and specifically relates to a method, system and related products for analyzing the prognosis of hepatocellular carcinoma patients who meet the Milan criteria who are planning or have undergone liver transplantation. Through the implementation of the method, system and related products The obtained results can provide intermediate or auxiliary information for the assessment and prediction of primary tumor metastasis and recurrence risk after liver transplantation in patients with hepatocellular carcinoma. Background technique [0002] Primary liver cancer is one of the malignant tumors with the highest incidence rate in the world, and more than 1 million people are newly diagnosed with this disease every year. The incidence of liver cancer in my country has always ranked first in the world, and about 230,000 people die of liver cancer every year, accounting for 53% of the deaths of liver...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57438G01N33/57484G01N2333/4722G01N2333/4742
Inventor 冯骥良
Owner 冯骥良
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